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Research Article Open access CC BY 3.0

Understanding of Malaria and Its Therapeutic Regimens–The Way Forward

`Saganuwan Alhaji Saganuwan, Patrick Azubuike Onyeyili

International Journal of TROPICAL DISEASE & Health · pp. 802–840 · Published 23 May 2014

10.9734/IJTDH/2014/8920

Abstract

Aim: Malaria is a very serious deadly disease that has attracted the attention of many researchers all over the world. Because a lot of work has been done in the area of malariology, there is need to understand its advance pattern and therapeutic regimens. Methods: Past and recent literatures on malaria were searched for information on history, global situation, classification, biology, pathology, pathogenesis, diagnosis, treatment and control of malaria to assess the progress made so far in the area of malariology. Results: Malaria is an ancient disease recognized by Hippocrates over 2413 years ago, caused by Plasmodium species, first identified by Charles-laveran 123 years ago affect 300–500 millions human worldwide, responsible for 3 deaths in every 30 seconds. The knowledge of classification, biology, pathology, pathogenesis, diagnosis and treatment of malaria is a tremendous achievement towards the control of the disease. Conclusion: But complete elimination of malaria perhaps will still take another time, since lots need to be known about the molecular biology of antigenic shift and drift, nature and mechanisms of action of the parasite toxin, in order to have basis for definite vaccine development. By so doing, radical cure and total eradication of malaria can be achieved.

Malaria hippocrates laveran antigenic shift radical cure eradication

References (118)

  1. 1 Basic and Clinical Pharmacology
  2. 2 Common West African HLA antigens are associated with protection from severe malaria [DOI]
  3. 3 Reversal of Chloroquine Resistance in Plasmodium falciparum by Verapamil [DOI]
  4. 4 Efflux of Chloroquine from Plasmodium falciparum : Mechanism of Chloroquine Resistance [DOI]
  5. 5 The relationship between blood groups and disease [DOI]
  6. 6 THE BURDEN OF CO-INFECTION WITH HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 AND MALARIA IN PREGNANT WOMEN IN SUB-SAHARAN AFRICA [DOI]
  7. 7 Microbiology: A Human Perspective
  8. 8 The Oxford Companion to Food [DOI]
  9. 9 Molecules on the surface of the Plasmodium falciparum infected erythrocyte and their role in malaria pathogenesis and immune evasion [DOI]
  10. 10 Hemoglobin Variants and Disease Manifestations in Severe Falciparum Malaria [DOI]
  11. 11 The in vitro and in vivo antimalarial activity of Cardiospermum halicacabum L. and Momordica foetida Schumch. Et Thonn. [DOI]
  12. 12 Mechanisms of genetically-based resistance to malaria [DOI]
  13. 13 Factors affecting uptake of optimal doses of sulphadoxine-pyrimethamine for intermittent preventive treatment of malaria in pregnancy in six districts of Tanzania [DOI]
  14. 14 The Microbial World [DOI]
  15. 15 A synthetic vaccine protects humans against challenge with asexual blood stages of Plasmodium falciparum malaria [DOI]
  16. 16 Reversal of Chloroquine Resistance in Malaria Parasite Plasmodium falciparum by Desipramine [DOI]
  17. 17 Conserved residues in the Plasmodium vivax Duffy-binding protein ligand domain are critical for erythrocyte receptor recognition [DOI]
  18. 18 Antiplasmodial constituents of Cajanus cajan [DOI]
  19. 19 In vitro antiplasmodial activity of Brazilian Cerrado plants used as traditional remedies [DOI]
  20. 20 Does traditional birth attendant training improve referral of women with obstetric complications: a review of the evidence [DOI]
  21. 21 Simple and sensitive antimalarial drug screening in vitro and in vivo using transgenic luciferase expressing Plasmodium berghei parasites [DOI]
  22. 22 Screening of antiplasmodial properties among some traditionally used Iranian plants [DOI]
  23. 23 HIV, malaria parasites, and acute febrile episodes in Ugandan adults: a case–control study [DOI]
  24. 24 Field study site selection, species abundance and monthly distribution of anopheline mosquitoes in the northern Kruger National Park, South Africa [DOI]
  25. 25 Parasite clearance following treatment with sulphadoxine-pyrimethamine for intermittent preventive treatment in Burkina-Faso and Mali: 42-day in vivo follow-up study [DOI]
  26. 26 The malaria vaccine: anti-parasite or anti-disease? [DOI]
  27. 27 Adverse reactions to sulfa drugs: implications for malaria chemotherapy.
  28. 28 ON THE HÆMATOZOAN INFECTIONS OF BIRDS [DOI]
  29. 29 In vitro and in vivo antiplasmodial activity and cytotoxicity of extracts of Phyllanthus niruri L. herbs traditionally used to treat malaria in Indonesia.
  30. 30 Determinants of the Permethrin Impregnated Bednets (PIB) in the Republic of Benin: the role of women in the acquisition and utilization of PIBs [DOI]
  31. 31 Decreased malaria morbidity in the Tharu people compared to sympatric populations in Nepal [DOI]
  32. 32 Screening of the antimalarial activity of plants of the Cucurbitaceae family [DOI]
  33. 33 Adhesion of Plasmodium falciparum-infected red blood cells to CD36 under flow is enhanced by the cerebral malaria-protective trait South–East Asian ovalocytosis [DOI]
  34. 34 Tropical Plants with Antihypertensive, Antiasthmatic, and Antidiabetic Value [DOI]
  35. 35 The feasibility, patterns of use and acceptability of using mobile phone text-messaging to improve treatment adherence and post-treatment review of children with uncomplicated malaria in western Kenya [DOI]
  36. 36 Evaluation Of In-Vitro Antimicrobial Activities And Phytochemical Constituents Of Cassia occidentalis [DOI]
  37. 37 Malaria vaccines: looking back and lessons learnt [DOI]
  38. 38 Status of antimalarial drugs under development.
  39. 39 ON THE FLAGELLATED FORM OF THE MALARIAL PARASITE. [DOI]
  40. 40 Chemical Composition and Antimicrobial Activity of Essential Oil of Bupleurum montanum and B. plantagineum [DOI]
  41. 41 Human Antiparasitic Drugs: Pharmacology and Usage
  42. 42 Prevention and control of parasitic diseases in tropical Africa : main issues
  43. 43 Drug resistance and the P-glycoprotein homologues of Plasmodium falciparum [DOI]
  44. 44 Infectivity to Mosquitoes of Plasmodium Vivax and Plasmodium Falciparum under Various Conditions [DOI]
  45. 45 Indian Anti-Malaria OMARIA Is Effective Against African Drug Resistant P. falciparum Field Isolates and Laboratory Strains; without Toxicity [DOI]
  46. 46 In vivo anti-malarial effect of the ß-amino alcohol 1t on Plasmodium berghei [DOI]
  47. 47 Economic aspects of the use of impregnated mosquito nets for malaria control.
  48. 48 Microbiology in blood transfusion [DOI]
  49. 49 Medical entomology : arthropods and human disease
  50. 50 Observations on the Cytology and Morphology of the Mammalian Malaria Parasites. I. A Process of Apparent Plasmotomy in the Preerythrocytic Phase of Laverania falciparum.
  51. 51 Space-Time Relationships in Somesthetic Localization [DOI]
  52. 52 Antimalarial drug resistance and combination chemotherapy [DOI]
  53. 53 Effect of HIV-1 and increasing immunosuppression on malaria parasitaemia and clinical episodes in adults in rural Uganda: a cohort study [DOI]
  54. 54 Medicinal plants: a re-emerging health aid [DOI]
  55. 55 A review of malaria vaccine clinical projects based on the WHO rainbow table [DOI]
  56. 56 Pathogenesis of Malaria and Clinically Similar Conditions [DOI]
  57. 57 MALARIA IN PREGNANCY [DOI]
  58. 58 Change in composition of the Anopheles gambiae complex and its possible implications for the transmission of malaria and lymphatic filariasis in north-eastern Tanzania [DOI]
  59. 59 In Vitro and In Vivo Properties of Ellagic Acid in Malaria Treatment [DOI]
  60. 60 Mind the gaps - the epidemiology of poor-quality anti-malarials in the malarious world - analysis of the WorldWide Antimalarial Resistance Network database [DOI]
  61. 61 Mass primaquine treatment to eliminate vivax malaria: lessons from the past [DOI]
  62. 62 Malaria in overseas labourers returning to China: an analysis of imported malaria in Jiangsu Province, 2001–2011 [DOI]
  63. 63 Communicating the AMFm message: exploring the effect of communication and training interventions on private for-profit provider awareness and knowledge related to a multi-country anti-malarial subsidy intervention [DOI]
  64. 64 Prevention of cerebral malaria in children in Papua New Guinea by southeast Asian ovalocytosis band 3. [DOI]
  65. 65 Antiplasmodial activity of Punica granatum L. fruit rind [DOI]
  66. 66 Serum lipids and lipoproteins in malaria - a systematic review and meta-analysis [DOI]
  67. 67 Effects of medicinal plant extracts on growth of Leishmania (L.) amazonensis and Trypanosoma cruzi [DOI]
  68. 68 Ellagitannins of the fruit rind of pomegranate (Punica granatum) antagonize in vitro the host inflammatory response mechanisms involved in the onset of malaria [DOI]
  69. 69 Evaluation of three rapid diagnostic tests for the detection of human infections with Plasmodium knowlesi [DOI]
  70. 70 Hot spot or not: a comparison of spatial statistical methods to predict prospective malaria infections [DOI]
  71. 71 The biology of sexual development of Plasmodium: the design and implementation of transmission-blocking strategies [DOI]
  72. 72 Best practices for an insecticide-treated bed net distribution programme in sub-Saharan eastern Africa [DOI]
  73. 73 Use of a three-band HRP2/pLDH combination rapid diagnostic test increases diagnostic specificity for falciparum malaria in Ugandan children [DOI]
  74. 74 Declining malaria in Africa: improving the measurement of progress [DOI]
  75. 75 The temporal lagged association between meteorological factors and malaria in 30 counties in south-west China: a multilevel distributed lag non-linear analysis [DOI]
  76. 76 A qualitative study to assess community barriers to malaria mass drug administration trials in the Gambia [DOI]
  77. 77 Plasmodium ovale: a case of not-so-benign tertian malaria [DOI]
  78. 78 Seasonal changes in the antibody responses against Plasmodium falciparum merozoite surface antigens in areas of differing malaria endemicity in Indonesia [DOI]
  79. 79 Lessons learned from the use of HRP-2 based rapid diagnostic test in community-wide screening and treatment of asymptomatic carriers of Plasmodium falciparum in Burkina Faso [DOI]
  80. 80 A retrospective analysis of the protective efficacy of tafenoquine and mefloquine as prophylactic anti-malarials in non-immune individuals during deployment to a malaria-endemic area [DOI]
  81. 81 Efficacy and safety of artemether + lumefantrine, artesunate + sulphamethoxypyrazine-pyrimethamine and artesunate + amodiaquine and sulphadoxine-pyrimethamine + amodiaquine in the treatment of uncomplicated falciparum malaria in Bangui, Central African Republic: a randomized trial [DOI]
  82. 82 Malaria transmission-blocking immunity induced by natural infections of Plasmodium vivax in humans [DOI]
  83. 83 The bionomics of the malaria vector Anopheles farauti in Northern Guadalcanal, Solomon Islands: issues for successful vector control [DOI]
  84. 84 Behavioural divergence of sympatric Anopheles funestus populations in Burkina Faso [DOI]
  85. 85 Field evaluation of the photo-induced electron transfer fluorogenic primers (PET) real-time PCR for the detection of Plasmodium falciparum in Tanzania [DOI]
  86. 86 Malaria indicator survey 2009, South Sudan: baseline results at household level [DOI]
  87. 87 Low genetic diversity and functional constraint in loci encoding Plasmodium vivax P12 and P38 proteins in the Colombian population [DOI]
  88. 88 Four years’ monitoring of in vitro sensitivity and candidate molecular markers of resistance of Plasmodium falciparum to artesunate-mefloquine combination in the Thai-Myanmar border [DOI]
  89. 89 Optimizing the programmatic deployment of the anti-malarials artemether-lumefantrine and dihydroartemisinin-piperaquine using pharmacological modelling [DOI]
  90. 90 Mutational analysis of Plasmodium falciparum dihydrofolate reductase and dihydropteroate synthase genes in the interior division of Sabah, Malaysia [DOI]
  91. 91 Diversity and population structure of Plasmodium falciparum in Thailand based on the spatial and temporal haplotype patterns of the C-terminal 19-kDa domain of merozoite surface protein-1 [DOI]
  92. 92 Genetic variation and recurrent parasitaemia in Peruvian Plasmodium vivax populations [DOI]
  93. 93 Antiplasmodial activity of Setaria megaphylla [DOI]
  94. 94 Co‐infection with malaria and HIV in injecting drug users in Brazil: a new challenge to public health? [DOI]
  95. 95 A rapid sensitive, flow cytometry-based method for the detection of Plasmodium vivax-infected blood cells [DOI]
  96. 96 Blackwater fever in an uncomplicated Plasmodium falciparum patient treated with dihydroartemisinin-piperaquine [DOI]
  97. 97 Challenges facing providers of imported malaria-related healthcare services for Africans visiting friends and relatives (VFRs) [DOI]
  98. 98 Clinical Manifestations, Treatment, and Outcome of Hospitalized Patients with Plasmodium vivax Malaria in Two Indian States: A Retrospective Study [DOI]
  99. 99 Safety Evaluations of Drugs Containing Artemisinin Derivatives for the Treatment of Malaria [DOI]
  100. 100 Vivax malaria in an Amazonian child with dilated cardiomyopathy [DOI]
  101. 101 Screening of Indian plants for biological activity: I.
  102. 102 First case of a naturally acquired human infection with Plasmodium cynomolgi [DOI]
  103. 103 UK malaria treatment guidelines [DOI]
  104. 104 Insecticide resistance mechanisms associated with different environments in the malaria vector Anopheles gambiae: a case study in Tanzania [DOI]
  105. 105 Integrating rapid risk mapping and mobile phone call record data for strategic malaria elimination planning [DOI]
  106. 106 Microbiology: A Human Perspective
  107. 107 Genetics of infectious diseases [DOI]
  108. 108 Re-evaluation of microscopy confirmed Plasmodium falciparum and Plasmodium vivax malaria by nested PCR detection in southern Ethiopia [DOI]
  109. 109 Antimalarial Drug-Artemisia annua
  110. 110 Transmission Blocking of Year Round Resistant Malaria in Koraput (India) by OMARIA – A New Antimalarial Phytotherapy [DOI]
  111. 111 An In vitro Assay System for the Identification of Potential Antimalarial Drugs [DOI]
  112. 112 Researches on Malaria [DOI]
  113. 113 Prevalence and Risk Factors for Placental Malaria in Nnewi, South East Nigeria [DOI]
  114. 114 Diseases transmissible by blood transfusion: viral hepatitis and other infectious disorders.
  115. 115 Malaria Control - An Over View in India [DOI]
  116. 116 Malaria epidemic response: what the clinician needs to know
  117. 117 Handbook of African medicinal plants [DOI]
  118. 118 The last and the next hundred years of malariology.

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