Usefulness of Ascitic Fluid Cholesterol and Protein in the Differential Diagnosis of Ascites in Nigeria: Comparison with Conventional Cytology
International Journal of TROPICAL DISEASE & Health · pp. 25–33 · Published 21 Apr 2015
10.9734/IJTDH/2015/12611Abstract
Aim: This study was done to assess and evaluate the diagnostic accuracy of cholesterol and protein in differentiating ascites into malignant and non-malignant group in comparison with cytology. Study Design: A cross sectional study to determine the correlation between ascitic fluid cholesterol and protein and malignant and non-malignant ascites. Place and Duration of Study: This study was carried out at the clinics of gastroenterology, surgery, and obstetrics/gynecology at the Lagos University Teaching Hospital (LUTH), between August 2011 and July 2013. Methodology: A total of 75 consecutive patients of Nigerian origin with ascites (37 malignant and 38 non-malignant) were studied for total cholesterol and total protein concentration in ascites. Also, cytology was done for all the 75 samples of ascitic fluid. Statistical analyses were carried out using SPSS software (version 15.0), and the level of significance set at p<0.05 and p<0.001. Results: The ascitic fluid cholesterol and protein levels in malignant ascites were higher (values of 103.10±30.00 mg/dL for cholesterol and 38.72±18.00 g/L for protein respectively) than in non-malignant ascites (values of 33.20±22.00 mg/dL for cholesterol and 30.21±15.00 g/L for protein). The p value for cholesterol was less than 0.001. Cytology had sensitivity, specificity, positive predictive value, negative predictive value and overall diagnostic accuracy of 56.8%, 100%, 100%, 70.4%, and 78.6% respectively. Using a cut-off limit of 72.7 mg/dL, cholesterol had sensitivity, specificity, positive predictive value, negative predictive value and overall diagnostic accuracy of 94.6%, 94.7%, 94.6%, 94.7% and 94.7% respectively. Ascitic fluid total protein had sensitivity, specificity, positive predictive value, negative predictive value and overall diagnostic accuracy of 37.8%, 86.8%, 73.7%, 58.9%, and 62.7% respectively. Cholesterol was more sensitive than protein and cytology in the differentiating malignant from non-malignant ascites. Conclusion: It was concluded that measurement of cholesterol in ascitic fluid can differentiate between malignant and non-malignant ascites, and can supplement cytology in the differential diagnosis of ascites.
References (16)
- 1 Malignant Ascites [DOI]
- 2 Diagnosing ascites: Value of ascitic fluid total protein, albumin, cholesterol, their ratios, serum‐ascites albumin and cholesterol gradient [DOI]
- 3 Usefulness of ascitic fluid cholesterol as a marker for malignant ascites.
- 4 Pathophysiology of elevated ascites fluid cholesterol in malignant ascites [DOI]
- 5 Total discrimination of peritoneal malignant ascites from cirrhosis- and hepatocarcinoma-associated ascites by assays of ascitic cholesterol and lactate dehydrogenase [DOI]
- 6 Diagnosis of malignant ascites [DOI]
- 7 Diagnostic accuracy of sialic acid in the diagnosis of malignant ascites [DOI]
- 8 Fibronectin Concentration in Ascites Differentiates Between Malignant and Nonmalignant Ascites [DOI]
- 9 Ascites. I. The value of examination of ascitic fluid and blood for lipids and for proteins by electrophoresis.
- 10 Diagnostic Value of Ascitic Fluid Cholesterol Levels in the Prediction of Malignancy [DOI]
- 11 Ascitic fluid cholesterol in differential diagnosis of ascites.
- 12 Serum - Ascites Albumin and Cholesterol Gradients in Differential Diagnosis of Ascites -
- 13 Biomarkers of malignant ascites—a myth or reality [DOI]
- 14 Usefulness of serum ascites cholesterol gradient (SACG), total protein (TP) ratio and serum ascites albumin gradient (SAAG) in differentiating tuberculous ascites and cirrhotic ascites [DOI]
- 15 Elevated ascitic fluid fibronectin concentration [DOI]
- 16 [Diagnostic efficacy of albumin gradient in different causes of ascitis].
Cited by 1
M. Esawy, M. Shabana, Elsayed Abd Elbaser · 2019
Related research
- The Prevalence of Prediabetes and Its Association with Metabolic Syndrome and Insulin Resistance in the Central Indian Population — shares topic coverage
- Cholesterol and Fatty Acid Profiles of Some Bird Egg Varieties: Possible Health Implications — shares topic coverage
- Effect of Estradiol Valerate on Serum Biochemical Profiles in Aged Female Albino Rats — shares topic coverage
- The Effect of Pleurotus tuberregium (An Oyster Mushroom) Sclerotia on the Weight, Protein Content and Lipid Profile of Broiler Chickens — shares topic coverage
- Total Cholesterol and Triglycerides in Unmarried Males and Females of Azad Jammu and Kashmir, Pakistan — shares topic coverage
Article metrics
Real usage data collected on this platform.
29
Page views
0
PDF downloads
3
Outbound clicks
1
Citations
Views over time
Views by country
Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".
Traffic sources
Referring site, by host.
Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.