UV Spectrophotometric Method for the Simultaneous Determination of Desloratidine and Pseudoephedrine HCl in Combined Dosage Form
K. Hussain Raviteja, Mahesh Nasare, V. V. L. N. Prasad, Prakash V. Diwan
Journal of Pharmaceutical Research International · pp. 418–428 · Published 21 Dec 2013
10.9734/BJPR/2014/5615Abstract
Aims: UV Spectrophotometric Method for the Simultaneous Determination of Desloratidine and Pseudoephedrine HCl in combined Dosage form. Study Design: A simple, rapid and specific UV spectroscopic method with good sensitivity was developed and validated for the simultaneous determination of Desloratidine and Pseudoephedrine HCl in bulk and pharmaceutical dosage form. Place and Duration of Study: Department of pharmaceutical Analysis & Quality Assurance, School of Pharmacy, Anurag Group of Institutions, Venkatapur, R.R Dist, Andhra Pradesh, India during February 2013 and April 2013. Methodology: Vierodt’s (Simultaneous equation) method was performed for Estimation of Desloratidine and Pseudoephedrine HCl in Pharmaceutical dosage form. Results: In Ethanol the λmax of Desloratidine and Pseudoephedrine HCl was fixed as 240 and 258 nm respectively using a Shimadzu UV-Visible spectrophotometer. In this proposed method both drugs obeyed linearity within the concentration range of 5-30 μg/ml and 80-800 μg/ml for Desloratidine and Pseudoephedrine HCl respectively. The low RSD values indicate good precision and high recovery values indicate accuracy of the proposed method. The proposed method has been applied to the determination of drugs in commercial formulations. Assay results were in good agreement with label claim. The method was validated as per ICH guidliness. Conclusion: The developed method was simple, accurate, precise, specific, sensitive and reproducible which can be efficiently and easily applied to pharmaceutical dosage forms
References (30)
- 1 Response normalized liquid chromatography nanospray ionization mass spectrometry [DOI]
- 2 Effect of desloratadine versus placebo on nasal airflow and subjective measures of nasal obstruction in subjects with grass pollen–induced allergic rhinitis in an allergen-exposure unit [DOI]
- 3 Separation and determination of pseudoephedrine, dextromethorphan, diphenhydramine and chlorpheniramine in cold medicines by nonaqueous capillary electrophoresis [DOI]
- 4 Orthogonal extraction/chromatography and UPLC, two powerful new techniques for bioanalytical quantitation of desloratadine and 3-hydroxydesloratadine at 25 pg/mL [DOI]
- 5 Spectrophotometric, Spectrofluorometric and HPLC Determination of Desloratadine in Dosage Forms and Human Plasma [DOI]
- 6 A validated stability-indicating UPLC method for desloratadine and its impurities in pharmaceutical dosage forms [DOI]
- 7 High-performance liquid chromatographic method for the bioequivalence evaluation of desloratadine fumarate tablets in dogs [DOI]
- 8 Comparison of the effects of D‐(‐)‐ephedrine and L‐(+)‐pseudoephedrine on the cardiovascular and respiratory systems in man. [DOI]
- 9 Sensitive gas—liquid chromatographic method for the determination of loratadine and its major active metabolite, descarboethoxyloratadine, in human plasma using a nitrogen—phosphorus detector [DOI]
- 10 Pseudoephedrine is without ergogenic effects during prolonged exercise [DOI]
- 11 Validation of a sensitive and automated 96-well solid-phase extraction liquid chromatography–tandem mass spectrometry method for the determination of desloratadine and 3-hydroxydesloratadine in human plasma [DOI]
- 12 Reliable and specific high-performance liquid chromatographic method for simultaneous determination of loratadine and its metabolite in human plasma [DOI]
- 13 Structural characterization of in vitro rat liver microsomal metabolites of antihistamine desloratadine using LTQ‐Orbitrap hybrid mass spectrometer in combination with online hydrogen/deuterium exchange HR‐LC/MS [DOI]
- 14 Simultaneous determination of desloratadine and pseudoephedrine in human plasma using micro solid‐phase extraction tips and aqueous normal‐phase liquid chromatography/tandem mass spectrometry [DOI]
- 15 Simultaneous determination of rupatadine and its metabolite desloratadine in human plasma by a sensitive LC–MS/MS method: Application to the pharmacokinetic study in healthy Chinese volunteers [DOI]
- 16 Quantification of desloratadine in human plasma by LC-ESI-MS/MS and application to a pharmacokinetic study [DOI]
- 17 High performance thin layer chromatographic method for simultaneous estimation of ibuprofen and pseudoephedrine hydrochloride [DOI]
- 18 Simultaneous determination of desloratadine and its active metabolite 3-hydroxydesloratadine in human plasma by LC/MS/MS and its application to pharmacokinetics and bioequivalence [DOI]
- 19 Second-derivative Spectrophotometric Assay of Pseudoephedrine, Ibuprofen and Loratadine in Pharmaceuticals [DOI]
- 20 A Validated Stability-Indicating RP-UPLC Method for Simultaneous Determination of Desloratadine and Sodium Benzoate in Oral Liquid Pharmaceutical Formulations [DOI]
- 21 Effect of d-Pseudoephedrine on Cough Reflex and Its Mode of Action in Guinea Pigs [DOI]
- 22 Separation and Determination of Ephedrine and Pseudoephedrine by Combination of Flow Injection with Capillary Electrophoresis [DOI]
- 23 A Sensitive Spectrophotometric Method for the Determination of Desloratadine in Tablets [DOI]
- 24 DETERMINATION OF PSUEDOEPHEDRINE HYDROCHLORIDE, CETIRIZINE DIHYDROCHLORIDE AND PARACETAMOL UNCOATED TABLET BY RP-HPLC METHOD [DOI]
- 25 Reverse phase-high performance liquid chromatographic method for the analysis of paracetamol, cetirizine and pseudoephedrine from tablets
- 26 Simultaneous determination of pseudoephedrine hydrochloride and cetrizine hydrochloride by reverse phase high performance liquid chromatography [DOI]
- 27 A VALIDATED RP-HPLC METHOD FOR DETERMINATION OF GUAIFENESIN AND PSEUDOEPHEDRINE HYDROCHLORIDE IN TABLET DOSAGE FORM
- 28 Sedation with "non-sedating" antihistamines: four prescription-event monitoring studies in general practice Commentary: Reporting of adverse events is worth the effort [DOI]
- 29 Corrigendum to “A validated stability indicating UPLC method for desloratadine and its impurities in pharmaceutical dosage forms” [J. Pharm. Biomed. Anal. 51 (2010) 736–742] [DOI]
- 30 [Study on determination of desloratadine in human serum and its pharmacokinetics by HPLC/MS]. [DOI]
Cited by 12
Mohamed S. Ali, Tilal Elsaman · Pharmaceutical Chemistry Journal · 2021
T. Lakshmi Narasimhan, P. Raviteja, A. Chockalingam · IEEE Transactions on Wireless Communications · 2015
Tanumay Datta, Harsha S. Eshwaraiah, A. Chockalingam · IEEE Transactions on Vehicular Technology · 2016
Dawood Habboo Mohammed · AIP Conference Proceedings · 2023
Dmytro Leontiev, Vasyl Petrus, Natalia Volovyk · ScienceRise: Pharmaceutical Science · 2020
Swati Pandey, Ravindra Pandey, Shiv Shankar Shukla · Journal of AOAC INTERNATIONAL · 2022
Imad Osman Abu Reid, Sayda Mohamed Osman, Somia Mohammed Bakheet · Journal of Global Health Science · 2024
Rida Evalina Tarigan, Muchlisyam, Siti Morin Sinaga · AIP Conference Proceedings · 2021
Showing 8 of 12 known citations — external sources report more than can currently be individually listed.
Related research
- Estimation of Toxic Hexavalent Chromium (Cr6+) in Metal Components Present in Electronic and Electrical Materials with or without using Coordinating Ligands — shares topic coverage
- Using Mobile– iPhone as New Visible Colour Detector for Determination of Pharmaceutical (Potassium Permanganate) — shares topic coverage
Article metrics
Real usage data collected on this platform.
3
Page views
0
PDF downloads
0
Outbound clicks
12
Citations
Views over time
Views by country
Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".
Traffic sources
Referring site, by host.
Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.