Lung cancer remains the leading cause of cancer-related death globally, with non-small cell lung cancer (NSCLC) accounting for most cases. A critical subset of NSCLC is characterized by anaplastic lymphoma kinase (ALK) gene rearrangements, which drive tumor growth and progression...
Tucatinib is a highly selective tyrosine kinase inhibitor targeting the HER2 protein, representing a significant advancement in treating HER2-positive metastatic breast cancer (MBC), including cases with brain metastases. This review assesses the efficacy and safety of tucatinib...
Background: Advancements in research and technology have expanded the array of available cancer treatment options. Nonetheless, these treatments may adversely impact the overall health of patients. The specific influence of each treatment option or their combined effects on cance...
Bloodstream infections (BSIs) caused by Gram-negative bacteria (GNB) are a significant concern in patients with hematological malignancies (HM), particularly when multidrug-resistant (MDR) strains are involved. This review synthesizes key findings from studies investigating the e...
Background: Social media platforms have become indispensable tools for communication and information exchange, playing an increasingly significant role in the healthcare landscape. Within the realm of cancer care, these platforms provide valuable avenues for accessing information...
Fidelis Godae Beega, Kemzi Elechi-Amadi, Simeon Christopher Aloy, Sheudeen Abubakar Abiola, Okorocha, CyrilGentle Ugochukwu, Ibioku Elekima & Edna Ogechi Nwachuku·International Research Journal of Oncology·2024
While naturally occurring, heavy metals pose a significant global public health risk due to their extensive utilisation in industrial, residential, and agricultural activities, impacting the health of millions worldwide. Occupational and environmental exposure to these metals thr...
Cytotoxic chemotherapy was a tragic by-product of World War II. It was the major therapeutic modality employed but failed to win the War on Cancer during 1971-1976 declared by President Nixon. Despite the failure, killing of cancer cells (CCs) remained the commanding principle of...
Indroduction: This retrospective study aims to investigate the implications of the bifurcation of the abdominal aorta on radiation therapy planning for cervical cancer patients, within the broader context of assessing CT scans of various pelvic malignancies. Methods: Patients who...
Sulymon A. Saka, Martins O. Odafen, Obiajulum N. Emekolom, Blessed Oseikhuemen, Williams I. Courage, Akhigbe E. Marvelous, Chukwuka E. Elochukwu & Akhaine J. Precious·International Research Journal of Oncology·2024
Background: Prostate cancer poses a significant health challenge globally, necessitating comprehensive understanding, awareness, and proactive screening practices. Objective: This study addressed the existing gaps in knowledge, perceptions, and screening practices related to pros...
Nwokorie, Maureen Amaoge, Osaeloka C. Ekwueme, Ahuchaogu, King-David Ikenna, Alisigwe, Chinedu Stanley & Dilioha O. Jude·International Research Journal of Oncology·2024
Introduction: Cervical cancer is the fourth most common cancer among women globally, constituting a major public health problem with a mortality rate that is 18 times higher in low-income countries, including Nigeria, where there are over 8000 annual deaths attributable to cervic...
Arinze Anthony Onwuegbuna, Akunne Ijeoma Apakama, Emeka Akujuobi Chianakwalam, Chidiebele Malachy Ezeude, Bernard Chukwunonyerem Ochiogu, Anthonia Chinyelu Udeaja, Chisom God’swill Chigbo, Chidebe Christian Anikwe, Nworah Josiah Azubike Obiechina & George Uchenna Eleje·International Research Journal of Oncology·2024
Background: Retinoblastoma is a rare, curable but deadly intra ocular tumor affecting usually children under 5 years of age. Awareness, early detection and treatment determine vision preservation and patient’s survival. In low- and middle-income countries majority of children pre...
Aim: This study explored the sexuality-related lived experiences of women diagnosed with breast cancer during multimodal breast cancer treatment. Study Design: Qualitative exploratory descriptive design. Place and Duration of Study: Participants were recruited from the Oncology D...
Background: PIM1 kinase is a serine/threonine kinase known for its excessive production in various human cancers, particularly prostate cancer. This enzyme promotes prostate cancer development by adding phosphate groups to cellular components, preventing programmed cell death (ap...
The burden of lung cancer in Nigeria represents a significant clinical problem due to the high mortality rate. Added to this is the lack of a comprehensive cancer treatment strategy in Nigeria, resulting in underdiagnosis and poor access to treatment. Furthermore, the challenges...
Roy’lagbaja Fateemah Adekemi (Adebayo), Afolalu Olamide O., Olanrewaju John Adedayo, Alamu Sunday Olagbemiro & Amoo Olakunle M.·International Research Journal of Oncology·2024
Cervical cancer remains a leading cause of death among females in the developing country with poor prognosis attributed to lack of awareness about the disease and its prevention. This study sought to assess the uptake of cervical cancer screening service and associated factors am...