Ibrahim Bakhit Y. Elemam, Eman Abd elgadir M. Elshariff, Mohammed Abdelgader Elsheikh, Tibyan Abd Almajed Altaher, Ghanem Mohammed Mahjaf, Waha Ismail Yahia Abdelmula & Babbiker Mohammed Taher Gorish·International Research Journal of Oncology·2024
Background: Ovarian cancer is a deadly illness with little understanding of its biology. The tumor suppressor p63 is a homolog gene of p53. P63 has an important role in the development and differentiation of reproductive epithelium and interacts with p53 in human tumorigenesis. ...
Sheudeen Abubakar Abiola, Adline E. Ben-Chioma, Beega Godae Fidelis, Simeon Christopher Aloy, Anthony Augustine U. & Ibioku Elekima·International Research Journal of Oncology·2024
Breast cancer, a complex and heterogeneous disease, remains a leading cause of global cancer-related morbidity and mortality. According to the World Health Organization 2020 report, breast cancer is responsible for over 685,000 deaths. This comprehensive review explores epigeneti...
Aim: This study was a cross sectional study aimed at evaluating the concentration of the enzyme aromatase in premenopausal and postmenopausal women in Port Harcourt. Study Design: The study population comprised of apparently healthy premenopausal and postmenopausal women who were...
The homeobox (HOX) genes encode highly conserved, homeodomain-containing transcriptional factors that play a central role in embryonic development and the maintenance of cellular identity crucial to the differentiation of adult stem cells. Implicitly, the pathophysiological relev...
A right approach is essential to solve any illness. Cancer mortality remains at historic high and is still on the way to increase. The objective of this study is to find a right approach of cancer therapy to bring cancer mortality down. Myelodysplastic syndromes are diseases attr...
Cancer mortality is very high and is still increasing. The objective of this study is to rely on the restoration of chemo-surveillance to reduce cancer mortality called for by President Biden in his cancer moonshot initiative speech last year. The reason cancer mortality remains...
Breast cancer has been one of the most widespread cancer types in women worldwide. Breast cancer can be treated when detected early; otherwise, it has one of the highest mortality rates among cancer types. Many tools can be used for detection, but computer-based diagnosis systems...
Aims: This study aimed to investigate the effects of HIV infection and occupational exposure on the concentrations of selected toxic metals and essential trace elements such as zinc in relation to the carcinogenic process. Study Design: Comparative cross-sectional study. Place an...
Extravasation accidents involving vesicant chemotherapy products can lead to severe local tissue damage and long-term functional impairment. Intramuscular (IM) extravasation is particularly concerning due to potential deep tissue damage and limited accessibility for treatment. We...
This paper focuses on the relationship between HIF1A expression and the warburg effect. Considering that the warburg effect is a hallmark of cancer, it’s possible that it could be caused by a common mechanism within tumor microenvironments. This paper considers the common cause o...
The objective of this study is to present convincing evidence to show that abnormal methylation enzymes (MEs) are the most critical issue of cancer, and to call for the acceptance of cell differentiation agent (CDA) formulations as the right medicines for cancer therapy. CDA form...
Neurofibromatosis type 1 (NF1) is a genetic disorder characterized by the growth of both benign and malignant tumors in neural crest cells. Despite extensive research, only one medication has been approved for plexiform neurofibroma treatment, and no specific drugs exist for othe...
A crucial stage in the development of cancer is metastasis, which greatly increases patient morbidity and mortality. The process of metastasis involves several steps, starting with the local invasion of cancer cells into the surrounding tissues, then extravasation, colonization a...
Lung-only metastasis in Ewing Sarcoma (ES) is a rare presentation in an otherwise common skeletal malignancy with a poor 5-year overall survival (OS) of 30% and a 10-year event-free survival (EFS) of 50.3%, respectively. We report a first case of a 11-year-old male with ES lung-o...
Okelue Edwards Okobi, Sebastian A. Omenai, Tolulope Yemisi Ogunyemi, Lateef Kadiku, Chinwendu Olivia, Ayozie- Chukukere, Omoniyi Araromi, Ifeoma Anaya, Ibilola Akorede Sanusi, Omolola Okunromade, Endurance Evbayekha, Emeka Kenneth Okobi, Jane Nwafor & Abiodun Oladimeji·International Research Journal of Oncology·2023
Tissue staining techniques have been an integral part of pathology for over a century. These techniques allow pathologists to visualize the structure and composition of tissues under a microscope. These techniques play a crucial role in the diagnosis and treatment of a wide range...