Josiah Stephen, Ikechukwu Kanu, Nwamaka Nneka Onyedum, Edibokun Theresa Orobator, Catherine Rono, Ngwoke, Chinaza Faith, Victor Omeiza David, Wonderful Oluwatoyin Anosike & Lawrence John AJutor·Journal of Cancer and Tumor International·2025
HLA class I molecules are essential for presenting tumour antigens to cytotoxic T-cells, but their dysregulation in cancer enables immune evasion and limiting the efficacy of immunotherapies for cancer. The objective of this review is to explore the function of HLA class I change...
Open access
Research Article10.9734/jcti/2025/v15i3299
Background: There is an upsurge of cervical cancer cases worldwide, of which Ghana is no exception. However, despite the growing population of women suffering from this disease, not much research has been done. According to studies undertaken in other countries, survivors of cerv...
Open access
Research Article10.9734/jcti/2025/v15i3298
Oseghale, Ikalo David, Ikokwu, Godwin Mmaduabuchi, Ugoagwu, Kingsley Ugonna, Elizabeth Anuoluwa Akintayo, Matthew Gyang, Okiki Nosiru Quadri, Catherine Rono, Osedebamen Hilary Ralph-Okhiria & Odunvbun Praise·Journal of Cancer and Tumor International·2025
The tumor microenvironment (TME) is the complex ecosystem surrounding a tumor. It is a complex and continuously evolving entity. The TME comprises a variety of complex components, such as cancer cells, immune cells, stromal cells, and extracellular matrix, that precisely regulate...
Open access
Research Article10.9734/jcti/2025/v15i2297
The objective of this article is to promote abnormal methylation enzymes (MEs) as a critical cause of cancer and the destabilization of abnormal MEs as a new approach to direct cancer therapy. MEs are a ternary enzyme complex consisting methionine adenosyltransferase (MAT)-methyl...
Open access
Research Article10.9734/jcti/2025/v15i2295
Lawrence John AJutor, Edibokun Theresa Orobator, Blessing Ben- Anioke, Victor Chiedozie Ezeamii, Mayowa Josiah Badmus, Uchechi Ngozichukwu Obiefule, Vincent Barrah, Mary Oluwabunmi Oyebode & Josiah Stephen·Journal of Cancer and Tumor International·2025
BRCA1 and BRCA2 genes, located on separate chromosomes, encode crucial multifunctional proteins that are important for correcting errors in DNA replication and cell division. The two genes work in tandem at different stages in the DNA damage response and for DNA repair and could...
Open access
Research Article10.9734/jcti/2025/v15i2296
Chibuike Emmanuel Okafor, Emmanuel Cherechi Egwuatu, Victor Ayoola Owosagba, Teckla Njei, Bankole Israel ADEYEMI, Philip Ugbede Ojo Onuche, Abdullahi Adams, Chiamaka Blessing Ugwuja, Eze Samson Chibueze & Olabisi Promise Lawal·Journal of Cancer and Tumor International·2025
Cancer, a multifaceted clinical challenge, is driven by dysregulation of protein kinases—key regulators of critical cellular function. The introduction of kinase inhibitors has transformed targeted cancer therapy, ushering in a change from traditional chemotherapy to precision on...
Open access
Research Article10.9734/jcti/2025/v15i2294
Breast cancer remains one of the major global health challenges, the Human Epidermal Receptor-2 (HER-2) subtype is characterized by aggressive tumor growth due to overexpression of the HER2-positive. Early detection of HER2-positive breast cancer is crucial for improving patient’...
Open access
Research Article10.9734/jcti/2025/v15i2293
Background: Thyroid cancer, the most common endocrine neoplasia, has seen a rapid increase in global incidence, with the USA reporting over 62,000 new cases in 2015, making it the fifth most common cancer among women. Differentiated thyroid cancer accounts for more than 95% of ca...
Open access
Research Article10.9734/jcti/2025/v15i2291
Keren-Happuch Twumasiwaa Boateng, Samuel Kwame Amoako Asirifi, Williams Kwame Boateng, Irene Adu Boateng & Alhassan Ruhiya Nagumsi·Journal of Cancer and Tumor International·2025
Background: The death rate related to breast cancer in Africa is frighteningly high and the prevalence of breast cancer is continuously increasing. The majority of breast cancer cases that are diagnosed and treated quickly can be cured. However, in some cases, acquired resistance...
Open access
Research Article10.9734/jcti/2025/v15i2290
Leptomeningeal carcinomatosis (LC) is a rare but devastating manifestation of cancer that has undergone metastatic spread to the cerebrospinal fluid and leptomeninges. The most common malignancies associated with LC are melanoma, breast, and lung cancers. LC severely influences m...
Open access
Research Article10.9734/jcti/2025/v15i2289
Habib Olaniran Kolawole, Edibokun Theresa Orobator, Blessing Imade, Victor Damilare Oladele, Ezema Izuchukwu Gerald, Kamsiyochukwu Anita Ezeani, Daniel Ebubechi Obasi, Adegbesan Abiodun Christopher, Peter Bemigho Adewoyin & Lawrence John AJutor·Journal of Cancer and Tumor International·2025
There has been an increase in the amount of studies focusing on the relevance of tumour microenvironment (TME) in metastasis of breast cancer. Cancer-associated fibroblasts (CAFs) is one of the most abundant cells found in the TME that play key roles in the metastasis of cancers...
Open access
Research Article10.9734/jcti/2025/v15i2288
Background: Melanoma has shown resistance to conventional treatments, resulting in poor prognoses. Recent advancements in immunotherapy have improved patient outcomes. However, these therapies are associated with severe adverse reactions, raising concerns about their safety. Meth...
Open access
Research Article10.9734/jcti/2025/v15i1287
Aim: To review malignant tumours seen at Rivers State University Teaching Hospital from January 2017 to December 2022, to assess the gender and age distribution of these tumours and to assess whether there is a correlation between ages of these patients and these malignant tumour...
Open access
Research Article10.9734/jcti/2025/v15i1286
Dewa Ayu Made Adnyaswari, Agung Wiwiek Indrayani, I Gusti Ayu Artini, Desak Ketut Ernawati, I Gusti Made Gede Surya Candra Trapika, Ni Putu Sriwidyani & I Gusti Kamasan Nyoman Arijana·Journal of Cancer and Tumor International·2025
Aims: Tumor Suppressor p53 is a frequent research target to further understand the mechanisms of cancer development and the pathogenesis of cancer. Arginase-1 may also be a potential prognosis predictor for HCC patients, and also be a new target for HCC treatment. This research a...
Open access
Research Article10.9734/jcti/2025/v15i1285