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All published articles 419

Evaluation of Phytochemical, Antimicrobial Activities and Toxicological Analysis of Scent Leaf (Ocimum gratissimum L.) Leaf Extracts

M. Umar, C. P. Nkemelu, M. R. Sagir, S. Y. Mohammed, G. K. Ajiya, I. B. Mohammed, A. A. Yaya, A. A. Kigbu, S. A. Ojo, I. M. Abdulkarim, I. Y. Tafinta & I. C. Amuta · Asian Journal of Research in Medical and Pharmaceutical Sciences · 2019

Aim: The phytochemical screening, antibacterial activities and in vivo toxicity of extracts of the leaves of scent leaf (Ocimum gratissimum L.) were investigated. Methods: All the analyses were carried out using standard scientific procedures using Soxhlet extraction, well-diffus...

Open access Research Article 10.9734/ajrimps/2019/v7i330123

Effect of Methanolic Extract of Vernonia amygdalina Leaves on Glycemic and Lipidaemic Indexes of Wistar Rats

Emmanuel O. Ogbuagu, A. I. Airaodion, Uloaku Ogbuagu & Edith O. Airaodion · Asian Journal of Research in Medical and Pharmaceutical Sciences · 2019

Aim: This study sought to investigate the effect of methanolic extract of Vernonia amygdalina leaves on glycemic and lipidaemic indexes of Wistar rats. Methods: Fresh plants of V. amygdalina were harvested from the Institute of Agricultural Research and Training, Ibadan. The leav...

Open access Research Article 10.9734/ajrimps/2019/v7i330122

Cerebral Cortical Damage in Adult Wistar Rats Following Aluminium Chloride Administration

A. J. Ajibade, P. B. Fakunle & O. O. Omoola · Asian Journal of Research in Medical and Pharmaceutical Sciences · 2019

This study investigated some effects of aluminium chloride on the cerebral cortex of adult Wistar rats. Aluminium chloride as one of the toxic metals has been known to be one of the major environmental pollutants across the world which has been reported in relation to Neurodegene...

Open access Research Article 10.9734/ajrimps/2019/v7i330121

The Mechanical and In vitro Release Properties of Diazepam from Tablets Containing Fluid Bed Dried and Lyophilized Cocos nucifera Microcrystalline Cellulose

Nkemakolam Nwachukwu & Sabinus Ifeanyi Ofoefule · Asian Journal of Research in Medical and Pharmaceutical Sciences · 2019

Aim: This study aimed to evaluate the mechanical and in vitro release properties of diazepam from tablets containing fluid bed dried and lyophilized microcrystalline cellulose (MCC) obtained from the matured fruit husks of Cocos nucifera (CN). Study Design: Method of experiment....

Open access Research Article 10.9734/ajrimps/2019/v7i330120

Effects of Moringa oleifera Leaves Methanolic Extract on Alloxan- Induced Diabetic Albino Rats

C. Udeogu, C. C. Ejiofor & A. Nwakulite · Asian Journal of Research in Medical and Pharmaceutical Sciences · 2019

Moringa oleifera, popularly known as “miracle tree” belongs to the family, Moringaceae. It is a medicinal plant in which the leaves are the most nutritious part, being a significant source of vitamins and protein among others. This study was conceived and designed based on the ga...

Open access Research Article 10.9734/ajrimps/2019/v7i230119

In vitro Susceptibility Pattern of Major Gram Negative Isolates to Selected Antimicrobial Agents

Shalini Gupta & Pankaj Mandale · Asian Journal of Research in Medical and Pharmaceutical Sciences · 2019

Background: The choice of choosing right anti-microbial therapy in hospitals depends on the knowledge of local anti-microbial susceptibility profile. This retrospective study was conducted to assess the in vitro susceptibility pattern of different pathogen isolates to various ant...

Open access Research Article 10.9734/ajrimps/2019/v7i230117

Direct Compression and in vitro Release of Chlorpheniramine Maleate from Tablets Containing Fluid Bed Dried and Lyophilized Microcrystalline Cellulose Derived from Cocos nucifera

Nkemakolam Nwachukwu, Kenneth Chinedu Ugoeze, Ogbonna Okorie & Sabinus Ifeanyi Ofoefule · Asian Journal of Research in Medical and Pharmaceutical Sciences · 2019

Aims: To investigate the mechanical and in vitro release properties of chlorpheniramine maleate (CM) tablets formulated with fluid bed dried and lyophilized microcrystalline cellulose (MCC) derived from the fruit husk of Cocos nucifera (CN). Study Design: Experimental design. Pla...

Open access Research Article 10.9734/ajrimps/2019/v7i230118

Efficacy of Nebulised Tobramycin in Cystic Fibrosis Management: A Systematic Review

G. T. Olowe · Asian Journal of Research in Medical and Pharmaceutical Sciences · 2019

Cystic Fibrosis (CF) is a progressive clinical condition associated with decreased functionality of glands that produce mucus, sweat, and intestinal secretions. CF is one of the most common recessive genetic diseases that affect all ethnic groups without any known identified cure...

Open access Research Article 10.9734/ajrimps/2019/v7i230116

Efficacy of Combined Crude Extract of Curcuma longa and Moringa oleifera in the Prevention of Peptic Ulcer in Albino Rats

A. I. Airaodion, Olukunle A. Adekale, Edith O. Airaodion, Emmanuel O. Ogbuagu, Uloaku Ogbuagu & Etinosa U. Osemwowa · Asian Journal of Research in Medical and Pharmaceutical Sciences · 2019

Aim: This study is aimed at investigating the prophylactic efficacy of combined extract of Curcuma longa and Moringa oleifera leaf against indomethacin–induced ulcer in albino rats. Place and Duration of Study: This research was carried out in Ibadan Nigeria between November 2017...

Open access Research Article 10.9734/ajrimps/2019/v7i230115

Antibacterial Assessment of Crude and Fractionated Extracts of Vernonia amygdalina Leaf against Multiple Antibiotic Resistant Bacteria of Wound Infection

A. K. Onifade & O. O. Agunloye · Asian Journal of Research in Medical and Pharmaceutical Sciences · 2019

This study was conducted to determine the antibacterial effect of crude and fractionated extracts of leaves of Vernonia amygdalina against multiple antibiotic resistant bacteria isolate from wounds. The bacteria isolates obtained are: Staphylococcus aureus, Escherichia coli, Pseu...

Open access Research Article 10.9734/ajrimps/2019/v7i130114

Pyridinium Crosslinks (Pyd) in the Urine is Associated with Stunting in Neonates

Aslis Wirda Hayati, Alkausyari Aziz, Siti Rohaiza Ahmad & Sri Widia Ningsih · Asian Journal of Research in Medical and Pharmaceutical Sciences · 2019

Aims: The aim of the research is to evaluate the reliability of bone resorption biomarkers called Pyridinium Crosslinks (Pyd) in the urine of the neonates as an evaluation to bone growth of the neonate, as an indicator of stunting. Study Design:  A cross-sectional study. Place an...

Open access Research Article 10.9734/ajrimps/2019/v7i130113

Comparison of the Hyperglycemic Control of M. oleifera Leaves Aqueous Extract and Glibenclamide Tablets in Alloxan Monohydrate Induced Diabetic Rats

Josephine N. Kasolo, Agnes Namaganda, Joshua Nfambi, Ivan Kimuli, Haruna Muwonge & Isaac Okullo · Asian Journal of Research in Medical and Pharmaceutical Sciences · 2019

Introduction: Diabetes being one of the commonest non-communicable diseases worldwide has no cure. The available hypoglycemic drugs are costly, and have associated long-term side effects.  M. oleifera leaves are used in many countries in Africa and Asia to treat diabetes. The stu...

Open access Research Article 10.9734/ajrimps/2019/v7i130112

Comparative Evaluation of the Antibacterial Effects of Honey with Standard Antibiotic on Bacterial Isolates from Wound Infection

N. M. Bunza, A. S. Kumurya, A. A. Isah, B. O. Abdul Azeez & F. Nafiu · Asian Journal of Research in Medical and Pharmaceutical Sciences · 2019

Aim: The aim of this study was to compare the antibacterial activities of the Honey against Ciprofloxacin on four bacterial isolates from a wound. Study Design: It is a cross sectional comparative and observational study. Place and Duration of Study: The study was conducted in Us...

Open access Research Article 10.9734/ajrimps/2019/v7i130111

Screening of Antimicrobial Activity of Various Extracts of the Stem Justicia gendarussa

Dhanapal Venkatachalam, Akhib Rahman, Basil Sunny, Jensy Jacob, Nikhil Kuriyan, Reshma Raman & Ria Vaniapurackal · Asian Journal of Research in Medical and Pharmaceutical Sciences · 2019

Objective: The present study was designed to check in-vitro efficacy of Antibacterial and antifungal activity of aqueous and hexane extracts of stem of Justicia gendarussa against selected bacterial and fungal strains. Justicia gendarussa, belonging to the family Acanthaceae, com...

Open access Research Article 10.9734/ajrimps/2019/v6i430107

The Effects of Combined Ethanolic Leaf Extracts of Annona muricata and Artocarpus heterophyllus on Reproductive Parameters of Type 2 Diabetic Wistar Albino Rats

F. C. Anacletus, C. L. Onuah & K. T. Nwauche · Asian Journal of Research in Medical and Pharmaceutical Sciences · 2019

Aim: The aim of this research is to study the combined effects of the ethanolic leaf extracts of Annona muricata and Artocarpus heterophyllus on the reproductive parameters of type II diabetic wistar albino rats. Materials and Methods: Fifty-six (56) male wistar albino rats were...

Open access Research Article 10.9734/ajrimps/2019/v6i430108