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All published articles 419

Pytochemical Characterization, Evaluation of the Anti-diabetic Activity and Acute Toxicity of Azadirachta indica (Meliaceae) Seed Oil in Wistar Rat Models

Bezejea Nkeng-Asong, Tembe Estella Fokunang, Njinkio Nono Borgia, Mbong Grace, Ngameni Bathelemy, Tabi Omgba Yves, Ngudjoe Ervrard Marcel, Ndikum Valentine Nchafor, Ngadjui Bonaventure Tchaleu & Fokunang Charles Ntungwen · Asian Journal of Research in Medical and Pharmaceutical Sciences · 2019

Aim: Azadirachta indica A. Juss commonly called ‘Indian Lilac’ or ‘Margosa’ is used in the South West region of Cameroon to treat malaria, typhoid, intestinal worms and diabetes, and as mosquito repellent. Diabetes, a major risk factor for the development of cardiovascular diseas...

Open access Research Article 10.9734/ajrimps/2019/v6i430109

Evaluation of Phytochemical Content and Antioxidant Potential of Ocimum gratissimum and Telfairia occidentalis Leaves

A. I. Airaodion, A. H. Ibrahim, U. Ogbuagu, E. O. Ogbuagu, O. O. Awosanya, J. D. Akinmolayan, O. C. Njoku, O. O. Obajimi, A. R. Adeniji & O. A. Adekale · Asian Journal of Research in Medical and Pharmaceutical Sciences · 2019

Aim: The aim of this study is to compare the phytochemical content and antioxidant potential of Ocimum gratissimum and Telfairia occidentalis leaves. Study Design: This study was made to fit a one-way Analysis of Variance. Place and Duration of Study: This research was carried ou...

Open access Research Article 10.9734/ajrimps/2019/v7i130110

Prevalence of Liver-fibrosis Using FIB-4 in HIV-patients on Anti-retroviral Therapy in Nigeria and CD4 and TNF as Predictors

Josephine Iruolagbe, Robinson Ohanador, Beatrice Amene-Imananagha, Audu Abubakar, Obetta Jessica & A. W. Obianemmie · Asian Journal of Research in Medical and Pharmaceutical Sciences · 2019

Introduction: Liver disease remains a severe complication in HIV patients despite advances in treatment with anti-retroviral drugs. The aim of this study was to analyze and report the prevalence and predictors of liver fibrosis in Nigerian HIV-infected adults on antiretroviral th...

Open access Research Article 10.9734/ajrimps/2019/v6i430105

Phytochemical, Antibacterial and Toxicity Study of Leaf Extracts of Vernonia amygdalina, Delile on Salmonella Species

A. A. Farouq, G. D. Muomara, A. M. Magashi, S. M. Jodi, M. K. Nata’ala & K. B. Habibu · Asian Journal of Research in Medical and Pharmaceutical Sciences · 2019

Aim: The aim of the study is to evaluate the bioactive compounds, toxicity and anti-bacterial activities of leaf extract of Vernonia amygdalina. Methodology: The phytochemical analysis of Vernonia amygdalina to detect the presence of bioactive compounds (oxalate, tannins, saponin...

Open access Research Article 10.9734/ajrimps/2019/v6i430106

Evaluation of the Disintegration Properties of Khaya senegalensis Gum Using Paracetamol Tablets

D. N. O. Kuevi, E. Ayertey, D. A. Bartels & F. W. A. Owusu · Asian Journal of Research in Medical and Pharmaceutical Sciences · 2019

Background: Disintegrants are essential in the formulation of solid dosage forms such as tablets because they aid in the release of the active drug for therapeutic action. Disintegrating agents such as starch are currently posing challenges such as tablet softening and slow disin...

Open access Research Article 10.9734/ajrimps/2019/v6i330104

Factors of Increasing Benign Prostatic Hyperplasia in Saudi Arabia

Abdullah Almaliki · Asian Journal of Research in Medical and Pharmaceutical Sciences · 2019

Benign  prostatic hyperplasia (BPH) is one of the conditions known as prostate growth that accompanied by the lower urinary tract symptoms. There are many researches that were conducted in Saudi Arabia in order to identify the most important factors that are working in increasing...

Open access Research Article 10.9734/ajrimps/2019/v6i330103

Codeine-mediated Haematoxicity, Hepatotoxicity and Nephrotoxicity in Male Albino Rats

Abiodun Olusoji Owoade, Abdulrahman Abdullateef, Adewale Adetutu & Olubukola Sinbad Olorunnisola · Asian Journal of Research in Medical and Pharmaceutical Sciences · 2019

Objectives: This study aimed to investigate the effects of codeine administration on some haematological and biochemical indices in rats. Materials and Methods: Therapeutic dose (5 mg/kg/day), high dose (25 mg/kg/day) and extreme dose (50 mg/kg/day) of codeine were administered o...

Open access Research Article 10.9734/ajrimps/2019/v6i330102

Toxicological Effects and Histopathological Alterations of Diazinon and Alpha Cypermethrin on Male Albino Rats

Maher A. Hammad & Reem M. Ziada · Asian Journal of Research in Medical and Pharmaceutical Sciences · 2019

Background: In Egypt, risk assessment of pesticides usage and pesticides misuse to protect plants and increase productivity connected with health hazards and pollution problems have been of public interest. Around the world three million acute poisoning cases from pesticide expos...

Open access Research Article 10.9734/ajrimps/2019/v6i330101

Retracted: Glucocorticoid-Induced, Morpho-Functional Alterations in Pancreatic Beta Cells of Wistar Rats

A. Aigbiremolen, M. A. Omoirri, O. A. Udi, S. E. Iloh & M. Ogbonnaya · Asian Journal of Research in Medical and Pharmaceutical Sciences · 2019

Background: Though prolonged use of glucocorticoids has been reported to promote adverse effects, traditionally, high-dose glucocorticoids have been implicated in immune-suppression following organ transplant with Cortisone being a well-known artificial glucocorticoid. Objectives...

Open access Research Article 10.9734/ajrimps/2019/v6i230099

Effects of Crude Extract of Neem Bark on the Pancreas of Streptozotocin Induced Diabetic Wistar Rats

A. J. Ajibade, E. O. James & B. D. Kehinde · Asian Journal of Research in Medical and Pharmaceutical Sciences · 2019

This study investigated the histological and serum enzymatic activities of Azadirachta indica, an Indian medicinal plant, on the pancreas in streptozotocin induced diabetic adult wstar rats. Forty six adult wistar rats weighing 100 g to 220 g were randomly separated into four gro...

Open access Research Article 10.9734/ajrimps/2019/v6i330100

Microalbuminuria in Women with Risk Factors for Gestational Diabetes Mellitus in Some Selected Hospitals in Sokoto, Nigeria

M. K. Dallatu, A. M. Kaoje, A. U. Adoke, J. A. Kehinde & J. M. Bunza · Asian Journal of Research in Medical and Pharmaceutical Sciences · 2019

Gestational diabetes mellitus (GDM) is a common metabolic abnormality which affects approximately 2-5% of pregnancies. Risk factors such as previous infants with macrosomia, strong family history of type 2 diabetes or GDM, poor glycaemic control and high pre-pregnancy body mass i...

Open access Research Article 10.9734/ajrimps/2019/v6i230097

Serum Levels of Some Inflammatory Markers in Alloxan- Induced Diabetic Rats Treated with Aqueous Leaf Extract of Terminalia catappa and Exogenous Insulin

Ezekiel E. Ben, Asuquo E. Asuquo & D. U. Owu · Asian Journal of Research in Medical and Pharmaceutical Sciences · 2019

Background: Inflammation is said to be associated with hyperglycaemia and is implicated in the complications of diabetes. Aim: This study was designed to investigate the level of some inflammatory markers in blood of diabetic rats administered with aqueous leaf extract of Termina...

Open access Research Article 10.9734/ajrimps/2019/v6i230098

The Role of Serum Alpha-Amylase and Glycogen Synthase in the Anti-Diabetic Potential of Terminalia catappa Aqueous Leaf Extract in Diabetic Wistar Rats

Ezekiel E. Ben, Asuquo E. Asuquo & D. U. Owu · Asian Journal of Research in Medical and Pharmaceutical Sciences · 2019

Background: The endocrinal abnormalities in diabetes mellitus as one of the numerous metabolic disorders is associated with derangement in exocrine functions of the pancreas and ultimately influences blood glucose regulation. Aim: The study was aimed at assessing the role of alph...

Open access Research Article 10.9734/ajrimps/2019/v6i230096

Anti-hyperglycaemic and Mode of Action of Thaumatococcus danielli (BENN.) BENTH Ethanol Leave Extract in Streptozotocin-induced Diabetic Rats

Folorunsho A. Ajayi, Olubukola. S. Olorunnisola, Adewale. Adetutu, Folashade G. Olorunfemi, Abiodun O. Owoade, Peter Adegbola & Olusegun K. Afolabi · Asian Journal of Research in Medical and Pharmaceutical Sciences · 2019

Thaumatococcus danielli (Benn.) Benth, a member of the Maranthaceae family has continued to be of immense benefit to the people in the tropics especially in Nigeria. The leaf is widely used among the “Yoruba’s” as a wrapping leaf and for the management of diabetes mellitus. Aim:...

Open access Research Article 10.9734/ajrimps/2019/v6i230095

Shelf Life Assessment of Picralima nitida and Glibenclamide Using Bio-Based Dose-Response Relationship Method

Kenechukwu Keluo Onyechi & Chinenye Adaobi Igwegbe · Asian Journal of Research in Medical and Pharmaceutical Sciences · 2019

Stability testing confirms the safety and quality of an active pharmaceutical ingredient or product. The shelf life of Picralima nitida (herbal drug) and glibenclamide were evaluated using the bio-based dose-response relationship method by the use of animal model based on their p...

Open access Research Article 10.9734/ajrimps/2019/v6i130094