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All published articles 889

Phytochemistry and Toxicity of Methanol Root Extract of Costus lucanusianus

Hope Delesi Kagbo & Lilian Ayagogo Gospel · Journal of Advances in Medical and Pharmaceutical Sciences · 2020

Costus lucanusianus (ginger lily or monkey sugarcane) is a medicinal plant commonly used to treat various ailments in tropical Africa. The leaves, stem and sometimes the root have been exploited for this purpose. However, it is a common belief in the Niger Delta of Nigeria that t...

Open access Research Article 10.9734/jamps/2020/v22i330160

Effect of Caffeine at Different Concentrations on Behavior and Motor Activity in Mice

Sakina S. Saadawi, Khairi A. Alennabi, Sumaya Baayo, Amera Fares, Najwa Alosta & Suher M. Aburawi · Journal of Advances in Medical and Pharmaceutical Sciences · 2020

Aims: This article aimed to study the effect of different caffeine concentrations on behaviour and motor activity of mice. Place and Duration of Study: This study took place in Faculty of Pharmacy, University of Tripoli, and was conducted between 2017 to 2018. Methodology: The ex...

Open access Research Article 10.9734/jamps/2020/v22i330159

Highly Active Antiretroviral Therapy Depletes Some Antioxidant Parameters and Increases Free Radical Generation in Drosophila melanogaster

Walter Mdekera Iorjiim, Simeon Omale, Great David Bagu, Steven Samuel Gyang, Emmanuel Taiwo Alemika & Monday Alexander Etuh · Journal of Advances in Medical and Pharmaceutical Sciences · 2020

Objective: This study intended to evaluate the toxic effects of Efavirenz-based highly active antiretroviral therapy (EFVb-HAART) on some antioxidant parameters, and free radical generation in D. melanogaster. Materials and Methods: The study was carried out at the Centre of Exce...

Open access Research Article 10.9734/jamps/2020/v22i230158

Illness Perception is a Predictor of Medication Adherence and Health Related Quality of Life in Patients Living with Epilepsy

Unyime Eshiet, Bertha Ekeh & Sidney Oparah · Journal of Advances in Medical and Pharmaceutical Sciences · 2020

Objective: To determine the relationship between illness perception, medication adherence and health related quality of life in patients living with epilepsy. Design: A cross-sectional prospective survey among patients living with epilepsy recruited from two tertiary referral cen...

Open access Research Article 10.9734/jamps/2020/v22i230157

Susceptibility Patterns of Some Enteric Bacteria to Crude and Purified Bark Extracts of Annona muricata L.

Ebenezer Oluyemi Dada & Kehinde Yemisi Akinde · Journal of Advances in Medical and Pharmaceutical Sciences · 2020

Aims: This research was carried out to evaluate the susceptibility pattern of some enteric bacteria to crude and purified extracts of Annona muricata bark. Study Design: Experimental design. Place and Duration of Study: Department of Microbiology, Federal University of Technology...

Open access Research Article 10.9734/jamps/2020/v22i230156

Formulation and Physicochemical Characterization of Buccal Mucoadhesive Films Containing Alfuzocin Hydrochloride

Abikesh P. K. Mahapatra, Sonia P. Nagvenkar & Rajashree Gude · Journal of Advances in Medical and Pharmaceutical Sciences · 2020

The buccal region of oral cavity is a interesting target for the drug of choice administration. To increase prevent first pass metabolism and bioavailability, Alfuzocin Hydrochloride is embedded in buccal film for a sustained release over a period of 8 hours. The purpose of this...

Open access Research Article 10.9734/jamps/2020/v22i230155

Opposite Effects of F1 and F5 Fractions of Total Methanol Leaf-extract of Dialium guineense (Cesalpiniaceae) on Blood Glucose in Rat

Firmin Sylva Barboza, Madièye Sene, Dominique Doupa, Malick Ba, Alassane Wélé & Sy Guata Yoro · Journal of Advances in Medical and Pharmaceutical Sciences · 2020

The purpose of this study is to investigate the effects of total methanol leaf-extract of Dialium guineense (Cesalpiniaceae) and its fractions on blood glucose in rat. The fractions of methanol extract were obtained by chromatography Sephadex LH 20 gel, numbered F1 to F5. Experim...

Open access Research Article 10.9734/jamps/2020/v22i230154

Investigation of the Levels of Total Aflatoxin in Herbal Traditional Medicines from Selected Vendors Dealers in South-Eastern Nigeria

Richard C. Ikeagwulonu, Chinedum C. Onyenekwe, Ifeanyi O. Oshim, Nkechi A. Olise, Oluwayemisi Odeyemi & Chiedozie K. Ojidei · Journal of Advances in Medical and Pharmaceutical Sciences · 2020

Aim: To investigate the levels of total aflatoxin (AF) in herbal medicines from selected vendors in South- Eastern Nigeria. Study Design: This is a cross-sectional study designed to investigate the levels of aflatoxin (AF) mycotoxin in herbal traditional medicines selected random...

Open access Research Article 10.9734/jamps/2020/v22i130152

Socio-Demographic and Clinical Profiles of Cannabis Abusers Admitted for Treatment in a Tertiary Healthcare Facility in Uyo, South-South Nigeria

Jombo, Henry Effiong, Alphonsus Udo Idung & Victory Edet Iyanam · Journal of Advances in Medical and Pharmaceutical Sciences · 2020

Background: Cannabis is one of the commonly abused psychoactive substances worldwide. The increasing abuse of this psychoactive substance is recognized as a significant public health problem in many developing countries. A proper assessment of the patterns and trends of cannabis...

Open access Research Article 10.9734/jamps/2020/v22i130153

Evaluation of Antihyperlipidaemic Activities of Hydromethanolic Extracts of Dioscorea bulbifera

Bruno Chukwuemeka Chinko, Datonye Victor Dapper & Olaghaguo Maestephen Adienbo · Journal of Advances in Medical and Pharmaceutical Sciences · 2020

Introduction: Hyperlipidemia is a leading cause of cardiovascular diseases (CHDs) with treatment ranging from dietary management and the use of antihyperlipidaemic drugs. The desire for anti-hyperlipidaemic drugs with less side effects has led to the screening of medical with ant...

Open access Research Article 10.9734/jamps/2020/v22i130151

Lipidaemic and Hepatic Status of Type 2 Diabetic Rats Treated with the Polyherbal Capsule Glucoblock

O. N. Briggs, K. N. Elechi-Amadi, F. C. Ezeiruaku & R. E. Teme · Journal of Advances in Medical and Pharmaceutical Sciences · 2020

The scourge of diabetes has led to an increase in the use of complementary and alternative medicine. The lack of regulation and control leads to the indiscriminate use of these herbals, with potential risk to patients. Aim: This study evaluates the lipidaemic and hepatic status o...

Open access Research Article 10.9734/jamps/2020/v22i130150

Evaluation of the Levels of Ochratoxin A and Fumonisin B1 Mycotoxins in Herbal Traditional Medicines Selected from Vendor Dealers in Ebonyi State of Nigeria

Richard C. Ikeagwulonu, Charles C. Onyenekwe, Ifeanyi O. Oshim, Zeal C. Ikeagwulonu, Chiedozie K. Ojide & Nkechi A. Olise · Journal of Advances in Medical and Pharmaceutical Sciences · 2020

Aim: To determine the concentration of Ochratoxin A and Fumonisin B1 mycotoxins in herbal medications available in markets in Ebonyi State. Study Design: This is a cross-sectional study designed to determine the levels of Ochratoxin A and Fumonisin B1 mycotoxins in herbal traditi...

Open access Research Article 10.9734/jamps/2020/v22i130149

Aromatic Hydrazide Compounds That Inhibit the Growth of Mycobacterium tuberculosis

Ronald Bartzatt, Preeti Sule, Thushara Galbadage & Jeffrey D. Cirillo · Journal of Advances in Medical and Pharmaceutical Sciences · 2020

Aims: To demonstrate the efficacy of aromatic hydrazide compounds to inhibit growth of Mycobacterium tuberculosis. Study Design: To synthesize tuberculostats and test their antibacterial activity in-vitro. Place and Duration of Study: University of Nebraska, Durham Science Center...

Open access Research Article 10.9734/jamps/2019/v21i430148

Developement and Characterization of Floating Tablets of Nizatidine for Peptic Ulcer

Sunil T. Galatage, Suresh G. Killedar, Rushikesh B. Katakar, Ravindra B. Kumbhar, Maya Sharma & Pramodkumar J. Shirote · Journal of Advances in Medical and Pharmaceutical Sciences · 2020

The objective of the present research work is to develop an ideal floating drug delivery system of nizatidine to increase the gastric residence time in stomach. To overcome the short half life and lower bioavailability of drug in tablet form we developed the drug in the form of e...

Open access Research Article 10.9734/jamps/2019/v21i430146

Therapeutic Effect of Ethanol Extract of Anthocleista vogelii Stem Bark in the Treatment of Jaundice on Paracetamol-induced Hepatotoxicity in Adult Wistar Rats

B. A. Olatunji & C. U. Ogunka-Nnoka · Journal of Advances in Medical and Pharmaceutical Sciences · 2020

This study investigated therapeutic effect of ethanol extract of Anthocleista vogelii stem bark (EEAV) in the treatment of jaundice on paracetamol-induced hepatotoxicity in adult wistar rats. A total of 30 wistar rats weighing between 160-200 g were distributed into 6 groups comp...

Open access Research Article 10.9734/jamps/2019/v21i430145