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All published articles 889

Comparative Profiling of Solvent-mediated Phytochemical Expressions in Ocimum gratissimum and Vernonia amygdalina Leaf Tissues via FTIR Spectroscopy and Colorimetric Assays

Josephine Oluwagbemisola Tella & Saheed Oluwasina Oseni · Journal of Advances in Medical and Pharmaceutical Sciences · 2019

Objective: The beneficial role of extraction solvents is often ignored, yet very important in enhancing the therapeutic potential of plant extracts. This study was carried out to comparatively characterize and profile the bioactive phytochemical compounds expressed in different s...

Open access Research Article 10.9734/jamps/2018/v19i430095

Chemical Characterization and In vitro Antimicrobial Activity of Caralluma europaea Essential Oil and Its Synergistic Potential with Conventional Antibiotics

Loubna Ait Dra, Abdellah Aghraz, Brahim Boualy, Saadia Oubaassine, Mustapha Barakate, Mohamed Markouk & Mustapha Larhsini · Journal of Advances in Medical and Pharmaceutical Sciences · 2019

Aim: This study was carried out to investigate the antioxidant and antimicrobial activities of essential oil from the aerial part of Caralluma europaea and to evaluate the synergistic potential between essential oil and antibiotics. Methodology: The chemical composition, antioxid...

Open access Research Article 10.9734/jamps/2018/v19i430094

The Effect of Artemisinin-based Combination Therapy (ACT) Antimalaria Drugs on Liver Enzymes in Pregnancy

Ajibade Oluwagbenga Oyeyemi & Ayobola Abimbola Sonuga · Journal of Advances in Medical and Pharmaceutical Sciences · 2019

Aims: Artemisinin-based Combination Therapies (ACTs) are employed as first-line agents in malaria chemotherapy. This study is aimed at assessing the effects of ACTs on renal function of pregnant women. Study Design: Comparative study. Place and Duration of Study: Pregnant women a...

Open access Research Article 10.9734/jamps/2018/v19i430093

Histological Effects and Prenatal Exposure to Crude Aqueous Extract of Morinda lucida Leaves on the Frontal Cortex of Growing Wistar Rats

O. O. Adeleye, A. A. Akande & A. A. Odetola · Journal of Advances in Medical and Pharmaceutical Sciences · 2019

Background: The use of medicinal plants has always been part of human culture and is common in Africa. Amongst the medicinal plants commonly used in Nigeria for management/ treatment of various types of ailments is Morinda lucida Benth. Aims: This research work was designed to in...

Open access Research Article 10.9734/JAMPS/2018/46182

Basic Pharmacology of NG -Nitro – L – Arginine Methyl Ester

Muhanad S. Abdelwahab, Mukhallad A. M. Mohammed, H. M. Abdelwhab, Mazin S. Abdalla Mohamed & Mansour Abdelgader Bellal · Journal of Advances in Medical and Pharmaceutical Sciences · 2019

NG – Nitro- L- arginine methyl ester (L-NAME) is a synthetic drug in which a quanidino is substituted for L-arginine analoques. It is a competitive enzyme inhibitor which inhibits nitric oxide synthase, hence, decreasing nitric oxide production [1].

Open access Research Article 10.9734/JAMPS/2018/46307

Haematologic and Gastric Histological Changes Associated with Administration of Ground Nutmeg (Myristica fragrans) Seed on Adult Male Albino Wistar Rats

Christopher Chiedozie Mbadugha, Gabriel Donatus Edem, Uka Emmanuel & Isaac Etim Udoudo · Journal of Advances in Medical and Pharmaceutical Sciences · 2019

Introduction: Substantially unproven scientifically are numerous assumed health benefits of nutmeg, moreover, a few of the scientifically substantiated research done were on the nutmeg oil and the mace. There is paucity of data based on scientific protocol on research carried out...

Open access Research Article 10.9734/JAMPS/2018/46509

Dose-dependent Effect of Avocado Peel Hydroethanolic Extract on Antioxidant Status of Heart and Kidney Tissue Homogenates in Wistar Rats

Daniel Y. Onoja, Arthur N. Chuemere, Kolawole A. Tolunigba, Mobisson S. Kelechi & Ilochi N. Ogadinma · Journal of Advances in Medical and Pharmaceutical Sciences · 2019

This study evaluated the dose-dependent effect of avocado (Persea americana) peel hydroethanolic extract on antioxidant status of heart and kidney tissue homogenates in wistar rats. A total of 60 wistar rats were used and the study period lasted for 42 days. The animals were rand...

Open access Research Article 10.9734/JAMPS/2018/46358

Potential Hazards of Ethanolic Extract of Garcinia kola on the Testes of Adult Male Wistar Rats

E. O. Nweke, J. K. Opara & I. J. Okafor · Journal of Advances in Medical and Pharmaceutical Sciences · 2019

Background: Garcinia kola has been used in the treatment of a wide range of diseases and its importance in folkloric medicine is eminent. Aim: This study investigated the histological effect of ethanolic extract of G. kola on the testes of male Wistar rats. Materials and Methods:...

Open access Research Article 10.9734/JAMPS/2018/46524

Predictive Factors of Anaemia in Women in a Ghanaian Rural District

Dinah Asantewah Koranteng, Franklin Acheampong, Isaac Koranteng & Richard Adanu · Journal of Advances in Medical and Pharmaceutical Sciences · 2019

Background: Anaemia is a condition of public health concern worldwide especially in developing countries. Anaemia falls in the top ten causes of morbidity in Ghana with a nationwide prevalence of about 45%. A rural district (Shai-Osudoku District), close to the capital city in Gh...

Open access Research Article 10.9734/JAMPS/2018/46017

Functional Compounds of Lobelia inflata Revealed Novel Potential Targets for Chronic Cough Therapy

Toluwase Hezekiah Fatoki, Olusola Olalekan Elekofehinti, Afolabi Clement Akinmoladun & David Morakinyo Sanni · Journal of Advances in Medical and Pharmaceutical Sciences · 2019

Aim: To identify potential targets involved in chronic cough pathophysiology toward discovery and development of new therapeutants. Methodology: This work was carried out on bioactive compounds of selected medicinal plants with reference to known therapeutic agents using computat...

Open access Research Article 10.9734/JAMPS/2018/45276

Extracts of Ageratum Conyzoides L. Protects against Carbon Tetrachloride – Induced Toxicity in Rats through Inhibiting Oxidative Stress

Frederick Sarfo-Antwi, Christopher Larbie & Duduyemi Babatunde · Journal of Advances in Medical and Pharmaceutical Sciences · 2019

Aims: The present study was aimed at investigating the hepatoprotective and nephroprotective activities of 50% hydroethanolic leave extracts of the Ageratum conyzoides and fractions on carbon tetrachloride - induced hepatotoxicity in rats. Study Design: A total of 30 Sprague Dawl...

Open access Research Article 10.9734/JAMPS/2018/45189

Determination of Haematocrit, Erythrocyte Sedimentation Rate (ESR) and Methaemoglobin Levels in Municipal Solid Waste Collectors (Sanitation Workers) in Port-Harcourt, Nigeria

Onengiyeofori Ibama & Felix Eedee Konne · Journal of Advances in Medical and Pharmaceutical Sciences · 2018

Aim: This study was carried out to ascertain whether or not occupational exposure affects the haematocrit, erythrocyte sedimentation rate, and methaemoglobin levels of municipal solid waste (MSW) collectors. Methodology: A total of 60 male subjects were recruited for this study,...

Open access Research Article 10.9734/JAMPS/2018/46187

Impacts of Analogy and Dimerization of Bioactive Compounds on Molecular Biological Functions

Toluwase H. Fatoki, Oladoja A. Awofisayo, Olusola A. Ogunyewo, Harriet U. Ugboko & David M. Sanni · Journal of Advances in Medical and Pharmaceutical Sciences · 2018

Aim: To determine the effect of analogy and dimerization of bioactive compounds at the molecular level on the biological functions. Methodology: This work was carried out on a model set of bioactive compounds which consisted of resveratrol, piceatannol, isorhapontigenin, scirpusi...

Open access Research Article 10.9734/JAMPS/2018/45211

Risky Sexual Behaviours among Youths in Selected Communities in Obio-Akpor and Ikwerre Local Government Areas of Rivers State, Nigeria

Nwondah, Chigozie & Alabere, Ibidabo · Journal of Advances in Medical and Pharmaceutical Sciences · 2018

Background: Youths are referred to as people of age group 15 to 24 years, and with significant physiological, psychological and social changes that place their lives at high risk. Risky sexual behaviour is the act of indulging in unprotected sexual intercourse through oral, anal...

Open access Research Article 10.9734/JAMPS/2018/45341