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All published articles 889

Assessment of Risk Involved in the Combination Medicine of Paracetamol and Caffeine

Md. Sahab Uddin, Md. Waliullah Wali, Abdullah Al Mamun, Md. Asaduzzaman, Md. Shah Amran & Mamunur Rashid · Journal of Advances in Medical and Pharmaceutical Sciences · 2015

Paracetamol (acetaminophen) with caffeine is a combination medicine indicated for the temporary relief of pain and discomfort associated with a number of conditions such as headache or muscle pain. There is a controversy going on this combination concerning their safety in patien...

Open access Research Article 10.9734/JAMPS/2016/22198

Effect of Resveratrol on Some Biochemical Parameters in Lead-intoxicated Male Wistar Rats

Salisu Muhammad Highab, Danjuma Nuhu Muhammad & Musa Aliyu · Journal of Advances in Medical and Pharmaceutical Sciences · 2015

Resveratrol is a potent antioxidant, demonstrated to ameliorate adverse effects of heat stress-induced toxicity. Information on the ameliorative effect of resveratrol on heavy metals induced organ toxicity is scanty. The aim of this experiment was to investigate the effect of res...

Open access Research Article 10.9734/JAMPS/2016/21835

MicroRNA Memory II: A Novel Scoring Integration Model for Prediction of Human Disease by MicroRNA/MicroRNA Quantum Multi-Interaction

Tatsunori Osone, Masaru Yoshikawa & Yoichi R. Fujii · Journal of Advances in Medical and Pharmaceutical Sciences · 2015

Aims: To further investigate quantum characters of the microRNA (miRNA) gene as the disease memory device, we calculated neo-score tool for miRNA/miRNA multi-interaction. Since the potential miRNA/target interaction is not one-to-one correspondence; therefore, the network of miRN...

Open access Research Article 10.9734/JAMPS/2016/22095

Evaluation of Antibacterial Potency of Crude Ethyl Acetate and Ethanol Extracts of Morinda lucida Leaf, Stem and Bark on Mycobacterium Species, Isolated from the Chest Hospital, Obafemi Awolowo Teaching University, Ile-Ife, Osun State, Nigeria

Osuntokun Oludare Temitope, A. O. Oluduro, O. V. Odubanjo & T. O. Dada · Journal of Advances in Medical and Pharmaceutical Sciences · 2015

The plant Morinda lucida falls under the family Rubiaceae known to have wide usage in traditional medicine. Morinda lucida is a tropical West African tree of medium-size about 18–25 m tall, the bark is grey to brown in colour, flowers are white in colour, the fruit is a drupe, se...

Open access Research Article 10.9734/JAMPS/2016/20705

Rescuing Abandoned Molecules as Nav1.7 and PCSK9 Inhibitors

Giuseppe Amico, Livia Basile, Giuseppe Romeo, Loredana Salerno, Maria N. Modica, Maria A. Siracusa, Agostino Marrazzo, Valeria Pittalà & Salvatore Guccione · Journal of Advances in Medical and Pharmaceutical Sciences · 2015

Academic institutions have plentiful of unexploited compounds. A cost-effective repositioning strategy from abandoned molecules coming from different research projects was applied. This strategy was based on the creation of a 2D-database then the biological assaying following adh...

Open access Research Article 10.9734/JAMPS/2016/22023

Development and Estimation of an in Silico Model for Anti-HIV-1 Integrase Inhibitor Using Genetic Function Approximation

Emmanuel Israel Edache, Adamu Uzairu & Stephen Eyije Abechi · Journal of Advances in Medical and Pharmaceutical Sciences · 2015

Aim: Integrase inhibitors are an essential enzyme required for replication of the acquired immunodeficiency syndrome virus. It is a potent target for anti- HIV therapy. A QSAR study is performed on the series indole -diketo, diketo acid and carboxamide derivatives in order to ana...

Open access Research Article 10.9734/JAMPS/2016/22227

Fatal Herb Senna: A Case Report

Muhammet Gokhan Turtay, Kasim Turgut, Hakan Oguzturk, Sukru Gurbuz & Volkan Ince · Journal of Advances in Medical and Pharmaceutical Sciences · 2015

Due to its laxative effects, senna (Cassia angustifolia) has been used frequently in our country and the whole world. We aimed to present a case in which a probable hepatotoxicity and death occurred because of senna used in large quantities for a long time due to its laxative eff...

Open access Research Article 10.9734/JAMPS/2016/21923

Effects of Administration of Methanol Root Bark Extract of Cussonia arborea on Serum Biochemical Markers of Kidney Damage and Renal Histomorphology of Alloxan-induced Diabetic Rats

Patrick Emeka Aba & Isaac Uzoma Asuzu · Journal of Advances in Medical and Pharmaceutical Sciences · 2015

Aim: This study evaluated the effects of oral administration of varied doses of methanol root bark extract of Cussonia arborea on some serum biochemical markers of kidney damage and renal histomorphology of alloxan-induced diabetic rats. Methodology: A total of Seventy two (72) m...

Open access Research Article 10.9734/JAMPS/2016/22121

Histological and Histochemical Evaluation of Anticadmium Toxicity Effects of Moringa oleifera Seed Oil and Anacardium occidentale Nut Oil in the Hippocampus of Juvenile Male Wistar Rats

O. D. Omotoso, J. O. Owolabi, Y. J. Samanja, B. J. Dare, E. A. Ashamu & S. A. Adelakun · Journal of Advances in Medical and Pharmaceutical Sciences · 2015

The hippocampus is a part of the brain involved in memory formation, organization and storage; being a limbic system structure that is particularly important in forming new memories and connecting emotions and senses, such as smell and sound, to memories. Cadmium on the other han...

Open access Research Article 10.9734/JAMPS/2016/16035

Evaluation of Nutritional, Antifungal Properties and Activities of Hydrolytic and Oxidative Enzymes of Coccinia cordifolia Leaves

M. S. Rahman, A. Nure & M. Asaduzzaman · Journal of Advances in Medical and Pharmaceutical Sciences · 2015

Objective: This study demonstrated the significant changes of nutritional compositions, hydrolytic and oxidative enzymes of C. cordifolia leaves at different maturity stages. Methods: Biochemical screening revealed the presence of reducing sugar, non-reducing sugar, starch, crude...

Open access Research Article 10.9734/JAMPS/2016/21876

Co-administration of Caffeine and Hydromethanolic Fraction of Citrullus lanatus Seeds Extract Improved Heamatological and Lipid Profile of Wistar Albino Rats

G. I. Onyeso, K. W. Nkpaa, J. N. Onokohwomo & O. V. A. Nwaeme · Journal of Advances in Medical and Pharmaceutical Sciences · 2015

Aim: This study was designed to evaluate the ameliorative effect of co-administration of caffeine (CF) and hydromethanolic fraction of Citrullus lanatus (CL) seeds extract on heamatological and lipid profile of wistar albino rats. Methods: Heamatological parameters were determine...

Open access Research Article 10.9734/JAMPS/2016/21832

Antibacterial Properties of Leaf Extracts of Moringa oleifera Lam. Growing in Sudan

Emad M. Abdallah · Journal of Advances in Medical and Pharmaceutical Sciences · 2015

Aim: To evaluate the antibacterial activity of different leaf extracts of Moringa oleifera growing in Sudan.  Methodology: The antibacterial activity of leaf extracts (Water, Butanol, Ethyl acetate and Chloroform) of Moringa oleifera were investigated in vitro using Agar-well dif...

Open access Research Article 10.9734/JAMPS/2016/21386

Positive Anti-Cadmium Poisoning Anti-Oxidant Effects of Moringa Seed Oil and Cashew Nut Oil in Juvenile Wistar Rats Hippocampus

O. D. Omotoso, J. O. Owolabi, H. B. Akpan, B. J. Dare, E. A. Ashamu & S. A. Adelakun · Journal of Advances in Medical and Pharmaceutical Sciences · 2015

Moringa oleifera seed oil and Anacardium occidentale oil contain certain antioxidants including ascorbic acid, phenolics, flavonoids and carotenoids; these antioxidants have potentials to act against oxidative stress generated by cadmium accumulation and activities in tissues. Th...

Open access Research Article 10.9734/JAMPS/2016/16310

Molecular Detection of Azurin: A Powerful Anticancer Protein from Native Pseudomonas Isolates

M. C. Sereena & Denoj Sebastian · Journal of Advances in Medical and Pharmaceutical Sciences · 2015

Aim: The present study was carried out to isolate azurin producing native Pseudomonas aeruginosa strains and confirm its presence using molecular techniques. Study Design: Presence of azurin detection by molecular techniques such as PCR and SDS PAGE. Place and Duration of the Stu...

Open access Research Article 10.9734/JAMPS/2016/20557

Assessment of Thrombolytic Activity of Selected Species from Lamiaceae Family Growing Naturally in Kurdistan Region\Iraq Using In-vitro Model

Lana Yousif Mutalib · Journal of Advances in Medical and Pharmaceutical Sciences · 2015

Aims: The present study was aimed to assess most commonly used medicinal plant belong to Lamiaceae family for their thrombolytic activity. Place and Duration of the Study: Pharmacy College\ Hawler Medical University, June, 2015. Methodology: Dried leaf part ethanolic extracts of...

Open access Research Article 10.9734/JAMPS/2015/20550