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Evaluation of Cytotoxic Potential of Digera muricata Leaf Extract on Lung Cancer Cell Line

S. Deepthi, P. Elumalai, S. Raghunandhakumar, T. Lakshmi & Anitha Roy · Journal of Pharmaceutical Research International · 2021

Lung cancer is the second most frequent cancer, accounting for one out of every five male cancers and one out of every nine female cancers. Treatment for lung cancer is determined by the disease's cell type, the extent to which it has spread, and the patient's overall health. It...

Open access Research Article 10.9734/jpri/2021/v33i63A35632

Production of Protease Enzyme and Antimicrobial Activities from Marine Actinobacterium of Streptomyces SP

R. Ananya, P. Sivaperumal, Anitha Roy & T. Lakshmi · Journal of Pharmaceutical Research International · 2021

Introduction: Actinobacteria are Gram-positive bacteria that have traits of both bacteria and fungus. They are found in both terrestrial and aquatic habitats and aid in the breakdown of deceased species' organic matter. Marine actinobacteria are unusual in that they have antibact...

Open access Research Article 10.9734/jpri/2021/v33i63A35634

Preparation of Methanolic Crude Extract of Padina Gymnospora Seaweed and their Anticancer Activities against Cancer Cell Line

Charanya Suresh, Anitha Roy, P. Sivaperumal & Lakshmi Thangavelu · Journal of Pharmaceutical Research International · 2021

Background: Cancer is a major health problem worldwide and still lacks fully effective treatments. As a result, natural-products-based alternative medicines have been developed. Marine algae are a vital part of the marine environment, with high biodiversity and contain a diverse...

Open access Research Article 10.9734/jpri/2021/v33i63A35635

Cytotoxic Effect of Lippia nodiflora Leaf Extract against the Prostate Cancer Cell Line

R. Sharmila, P. Elumalai, S. Raghunandhakumar, T. Lakshmi & Anitha Roy · Journal of Pharmaceutical Research International · 2021

Prostate cancer is the second most common cause of cancer deaths for men. Lippia. Nodiflora (L. nodiflora) has been used as a natural remedy for various diseases, because of its antioxidant, anti-inflammatory, anti-bacterial, and anti-tumor effect. This study was to investigate t...

Open access Research Article 10.9734/jpri/2021/v33i63A35638

Antiproliferative Efficacy of Centella asiatica Aqueoues Leaf Extract on Human Lung Cancer Cell Line

Amirtha Varshini & Lakshminarayanan Arivarasu · Journal of Pharmaceutical Research International · 2021

Aim: To assess the anti proliferative efficacy of Centella asiatica queoues leaf extract on human lung cancer cell line Introduction: Centella asiatica (family Apiaceae), commonly known as Indian Pennywort, is an ethnomedical plant that is widely used in India for treating skin p...

Open access Research Article 10.9734/jpri/2021/v33i63A35639

Preparation and Free Radical Scavenging Activity of Mint and Green Tea Formulation

R. Akshaya & Lakshminarayanan Arivarasu · Journal of Pharmaceutical Research International · 2021

Background: Antioxidants are an essential defence mechanism to protect our body against free radical damage. They balance the production of free radicals and detoxify them when in excess. Green tea manufactured from dried leaves of camellia sinensis. Mint belongs to the genus men...

Open access Research Article 10.9734/jpri/2021/v33i63A35640

Ameloglyphics why Not with Stains?- An Observational Study

Dinesh Yasothkumar, Abirami Arthanari, Pratibha Ramani & A. Melvin George · Journal of Pharmaceutical Research International · 2021

Background: In forensic Odontology, the term ameloglyphics refers to the study of enamel rod end patterns. These enamel rod end patterns are specific and are different for each individual. Enamel is the hardest tissue and it is resistant to several environmental factors like fire...

Open access Research Article 10.9734/jpri/2021/v33i63A35650

Organophosphorous Compounds in Assessment of Histomorphological Alterations of Natural Tooth

Snega Thamilselvan, Abirami Arthanari, R. Abilasha & Pratibha Ramani · Journal of Pharmaceutical Research International · 2021

Background: Pesticide poisoning has indeed been recognized as a significant global health problem, and it is the most common cause of morbidity and mortality.Organophosphorus compounds (OP) are extensively used in agriculture, domestic pest control, and biological agents. Each ye...

Open access Research Article 10.9734/jpri/2021/v33i63A35651

Qualitative and Quantitative Determination of Secondary Metabolites and Antioxidant Potential of Centaurea behen L. Root Extracts

Neesha Gupta & A. Kalaiselvan · Journal of Pharmaceutical Research International · 2021

Plants have been used by humans as a natural source for treatments and cures since ancient times, and medicinal herbs have gained popularity due to their widespread usage and lack of adverse effects. Plant study has grown in popularity across the world in recent years, and a larg...

Open access Research Article 10.9734/jpri/2021/v33i63A35822

Design, Synthesis and MAO Inhibitor Activity of Chroman-4-one Derivative

Somesh Kumar Saxena, Ashish Pathak & Om Prakash Agrawal · Journal of Pharmaceutical Research International · 2021

Two chalcones (4a, 4b) and nine Schiff bases (4c – 4k) of 7-hydroxy-3-formyl chromen-4-one have been synthesized. All the synthesized compounds 1–18 were screened for their hMAO (human Mono Amine Oxidase) inhibitory activity using recombinant human MAO isoforms. hMAO inhibitory a...

Open access Research Article 10.9734/jpri/2021/v33i63A35826

Analysis of Bleeding and Clotting Time among Patients Visiting a Private Dental Hospital - an Institutional Study

S. Kameswari & Pratibha Ramani · Journal of Pharmaceutical Research International · 2021

Introduction: Detection of dental problems starts from childhood, with regular check-ups to the dental specialist. Hemostasis is a stoppage of bleeding from damaged veins which includes a number of endothelial cells from vessels, small venules, or arterioles, then platelet plug i...

Open access Research Article 10.9734/jpri/2021/v33i63A35836

Study of Vital Capacity Relation to BMI in 1st-Year Medical Students

Anubhuti Sriwastwa & Angesh Bagade · Journal of Pharmaceutical Research International · 2021

Being overweight and other problems due to increasing weight increased BMI are looked forward as an “epidemic shoot up,” having a massive effect on every country in the world nevertheless it being developed or developing. Obesity is related to a vast range of devitalizing, enerva...

Open access Research Article 10.9734/jpri/2021/v33i63A35902

Formulation Development and Evaluation of Colon Targeting Nanosponges of Deflazacort Using Box Behnken Design

Sarvesh Mishra, Neeraj Sharma & Shailesh Jain · Journal of Pharmaceutical Research International · 2021

Deflazacort is a glucocorticoid that is often used as an anti-inflammatory and immunosuppressant for patients suffering from Inflammatory Bowel Disease such as ulcerative colitis (UC) and Crohn's disease (CD). IBD is difficult to manage, and the most difficult issue for doctors i...

Open access Research Article 10.9734/jpri/2021/v33i63A35961

Sensitive and Selective Analytical Method for the Quantification of Two Potential Genotoxic Impurities in Azilsartan Drug Substance by using LC-MS/MS with Multiple Reaction Monitoring (MRM mode)

Chandramohan Alluri, Kiran Kumar Naramsetti & G. Veera Raghava Sharma · Journal of Pharmaceutical Research International · 2021

The main aim of the present study to Synthesize,method development and method validation for quantification of two potential genotoxic impurities i.e., Methyl(Z)-2-ethoxy-1-((2'-(N'-hydroxycarbamimidoyl)-[1,1'-biphenyl]-4-yl) methyl)-1H-benzo[d]imidazole-7-carboxylate(Impurity-A)...

Open access Research Article 10.9734/jpri/2021/v33i63A36047

Analytical Method Development and Validation for Estimation of Bedaquiline (BDQ) Using RP-HPLC

Sharma Shubham, Dubey Nitin & Dubey Nidhi · Journal of Pharmaceutical Research International · 2021

The United States Food and Drug Administration (USFDA) approved bedaquiline (BDQ) in 2012 for the treatment of drug-resistant tuberculosis, which has become a serious global issue. For the measurement of bedaquiline in bulk medication, a reversed-phase high performance liquid chr...

Open access Research Article 10.9734/jpri/2021/v33i63A36048