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All published articles 7450

Extraction, Phytochemical Screening and Antioxidant Potential of Hydroalcoholic Extract of Aerial Parts of Bauhinia variegata

Amit Kumar Jain & Kavita R. Loksh · Journal of Pharmaceutical Research International · 2021

The goals of this research are to screen phytochemicals, perform thin layer chromatography, assess the quantity of phenolic and flavonoid compounds, and measure the antioxidant potential of Bauhinia variegata. The well-known test methodology available in the literature was used t...

Open access Research Article 10.9734/jpri/2021/v33i63A36060

Development, Characterization and Evaluation of Lactoferrin Conjugated and Memantine Loaded Peg-Plga Nanoparticles for the Treatment of Alzheimer's Disease

Rashi Jain & Virendra K. Sharma · Journal of Pharmaceutical Research International · 2021

Alzheimer's disease is a degenerative neurological condition that has no cure and only a few treatment options. It has a negative impact on one's cognitive and behavioural abilities. Traditional medications, such as acetylcholinesterase inhibitors, are often ineffective because t...

Open access Research Article 10.9734/jpri/2021/v33i63A36091

Reinforcement of Oral Epithelial Barrier Function by Vitamin D Induction of the Antimicrobial Peptide Cathelicidin. A Novel Therapeutic Approach in Chronic Periodontitis

Aditi Bose & H. N. Santosh · Journal of Pharmaceutical Research International · 2021

Introduction: Oral epithelium forms a physical, chemical and immunological barrier against the invading microorganisms. The chemical barrier mainly comprises of anti-microbial peptides (AMPs) like cathelicidins which are endogenously produced antibiotics. Transcription of the cat...

Open access Research Article 10.9734/jpri/2021/v33i63A36095

Measurement of Salivary Tumor Necrosis Factor- alpha (TNF- α) in Periodontitis Patients with or without Diabetes Mellitus

A. Swetaa, M. Jeevitha & Selvaraj Jayaraman · Journal of Pharmaceutical Research International · 2021

Introduction: Tumor necrosis factor-alpha (TNF-α) is a proinflammatory mediator considered to be a soluble mediator released from immunocompetent cells. It exercises a wide range of proinflammatory and immunomodulatory effects in different cell populations, such as stimulating pr...

Open access Research Article 10.9734/jpri/2021/v33i62B35163

Preparation and Antimicrobial Activity of Zinc Oxide Nanoparticles (Abies webbiana) Based Mouthwash

Prabhav Kumar Iyer, M. Jeevitha, S. Rajeshkumar & Selvaraj Jeyaraman · Journal of Pharmaceutical Research International · 2021

Introduction: Nanotechnology has been taking the scientific community by storm as they have been showing promising results due to their antibacterial, antifungal and cytotoxic activity. Multiple studies have found various plant species to be a rich source of these nanoparticles....

Open access Research Article 10.9734/jpri/2021/v33i62B35167

Chemotherapy Induced Secondary Spontaneous Pneumothorax in a Female with Endometrial Cancer- A Case Report

Srinivas Naik, Shazia Mohammad, Sourya Acharya, Neema Acharya & Anuj Varma · Journal of Pharmaceutical Research International · 2021

Endometrial cancer is one of the leading causes of death in post- menopausal women. It has significant impact on mortality and morbidity of women in the post-menopausal age group often requiring Hysterectomy along with Chemotherapy. Chemotherapy can be used to treat endometrial c...

Open access Research Article 10.9734/jpri/2021/v33i62B35168

Effect of Yoga in Stress Management in Patients with Epilepsy- A Literature Review

Jeekshitha Kulal, A. P. Rashmitha & K. U. Dhanesh Kumar · Journal of Pharmaceutical Research International · 2021

Objective: The major goal of this research evaluation was to see if yoga therapy may help people with epilepsy manage stress. Introduction: Epilepsy is a neurological disorder that has a high psychological and physical toll. Self-reported seizures are frequently caused by stress,...

Open access Research Article 10.9734/jpri/2021/v33i62B35169

m-NUTRIC Score for Assessment of Nutritional Status and Treatment Outcomes in Chronic Kidney Disease Patients

Prerna Verma, Sunil Kumar, Sourya Acharya, Shilpa Bawankule, A. K. Wanjari, Sachin Agrawal & Anand Bakre · Journal of Pharmaceutical Research International · 2021

Background: Malnutrition entails insufficiency arising of protein, vitamin, and trace elements related to inadequate and unstable diet which may cause poor quality of life and sometimes even lead to death. Undernourishment is the leading reason having a greater impact on outcomes...

Open access Research Article 10.9734/jpri/2021/v33i62B35564

Renal Cell Carcinoma Clear Cell Variant with Chromophobe Differentiation -A Rare Case Presentation

Tanvi Bhardwaj, K. M. Hiwale & Sunita Vagha · Journal of Pharmaceutical Research International · 2021

Renal Cell Carcinoma (RCC) is a diverse growth of various histological cell forms, as well as genetic, biological, and behavioral variations, accounting for around 2%-4% of all genitourinary cancers worldwide and having the highest mortality rate. RCC is a rare symptom that occur...

Open access Research Article 10.9734/jpri/2021/v33i62B35896

Assessment of 8-Hydroxy 2-Deoxyguanosine as Salivary Biomarker for Periodontitis Patients with or without Diabetes Mellitus

M. Ashwin Shravan Kumar, M. Jeevitha & Selvaraj Jayaraman · Journal of Pharmaceutical Research International · 2021

Aim: The aim of this study is to assess the levels of 8-hydroxy-2 deoxyguanosine as a salivary biomarker for periodontitis with or without diabetes mellitus. Study Design: Cross-sectional study Materials and Methods: 30 patients were included in the study and were categorised int...

Open access Research Article 10.9734/jpri/2021/v33i62B35164

A Scoping Review of the Genotypic Diversity of Streprococcus mutans

K. Kunguma Supraja, Saravanan Poorni, . Nivedhitha, Manali Ramakrishnan Srinivasan, M. Jeevitha & Selvaraj Jeyaraman · Journal of Pharmaceutical Research International · 2021

Aim: This paper reviews the literature on the pathogenic genotypes of S. mutans that may be more virulent colonizers and the phenotypic variability of its main virulence factors. Methods: A thorough literature search on S. mutans was performed and the relevant datas supporting it...

Open access Research Article 10.9734/jpri/2021/v33i62B35175

Necrotizing Fasciitis of the Breast and Leukemoid Reaction in an Immunocompetent Female: An Unforeseen Misadventure of LONG COVID Syndrome?

Nidhi Popat, Swarali Kale, Dhruv Talwar, Vinay Verma, Sunil Kumar, Samarth Shukla & Sunita Vagha · Journal of Pharmaceutical Research International · 2021

Necrotizing fasciitis is infrequently encountered but highly fatal group of infections. It is a infection of any of the three layers of soft tissue compartments which includes the dermis, subcutaneous tissue, superficial fascia,deep fascia or the muscle along with necrotising cha...

Open access Research Article 10.9734/jpri/2021/v33i62B35189

Development and Validation of UV-Visible Spectrophotometric Method for Estimation of Tacrolimus in Bulk and Pharmaceutical Nanoparticles

Snehal Patel, Chintan Aundhia, Avinash Seth, Nirmal Shah, Dipti Gohil, Ghanshyam Parmar, Sapna Desai & Kartik Pandya · Journal of Pharmaceutical Research International · 2021

A UV-visible spectrophotometric method for quantifying tacrolimus in nanoparticles has been developed and validated, and it is accurate, simple, reproducible, and affordable. For drug analysis, optimal conditions have been identified. 291 nm was discovered to be the maximum wavel...

Open access Research Article 10.9734/jpri/2021/v33i62B35192

Diastolic Dysfunction of the Left Ventricle in a Prediabetic Population from Rural Central India

Kshitij Bajpai, Shilpa Gaidhane & Sanket Vispute · Journal of Pharmaceutical Research International · 2021

According to a growing body of research, in people with type 2 diabetes mellitus (T2DM), cardiovascular diseases are a leading cause of mortality. Many studies have sought to understand the many pathways that may play a role in CVD in diabetics in a significant way. According to...

Open access Research Article 10.9734/jpri/2021/v33i62B35894