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All published articles 7450

Folic Acid Supplementation Diminishes Diabetes Induced Neural Tube Defects by Recovering Impaired Embryo Gene Expression Through Its Antioxidant Activity

Kevin Li, Xuyang Chen, Yuan Hu & Bingyan Gao · Journal of Pharmaceutical Research International · 2021

Aimes: This study aimed to determine whether folic acid supplementation could decrease the neural tube defects (NTDs) in embryos caused by hyperglycemia and the mechanism is associated with its antioxidative activity. Study Design: Diabetic pregnancy model were made and folic aci...

Open access Research Article 10.9734/jpri/2021/v33i62A35204

Knowledge and Awareness of Chronic Lower Respiratory Diseases among Smokers Population in Chennai, India: A Cross Sectional Questionnaire Survey

Pawan Kumar Earasi, R. Priyadharshini & Palati Sinduja · Journal of Pharmaceutical Research International · 2021

Aim: To analyse the knowledge and awareness of chronic lower respiratory diseases among the smoker population. Introduction: Tobacco is a key toxin in our civilization. Tobacco use and smoking is currently one of the leading causes of death and morbidity in both developed and dev...

Open access Research Article 10.9734/jpri/2021/v33i62A35539

Comparative Evaluation of Anti-diabetic Potential of Aqueous Seed Extracts of Momordica charantia, Seed Kernel Extract of Mangifera indica and Its Herbal Formulation – an in vitro Study

Chevuru Sai Shreya Reddy, R. Gayathri, V. Vishnu Priya, J. Selvaraj & S. Kavitha · Journal of Pharmaceutical Research International · 2021

Introduction: A condition in which the body’s ability gets impaired to process blood glucose level is called diabetes, otherwise known as blood sugar. It ranked sixteenth among leading causes of death around the globe. There are estimated 72.96 million cases diagnosed with diabet...

Open access Research Article 10.9734/jpri/2021/v33i62A35518

Age Estimation using Mandibular Projective Ramus Height: A Retrospective Digita Orthopantomographic Study

Suvarna Kizhakkoottu & Abirami Arthanari · Journal of Pharmaceutical Research International · 2021

Background: Mandibular projective ramus height is one of the accurate parameters in age estimation.Estimation of age by mandibular ramusheight using various digital softwares is one of the newest approach in forensic dentistry. The aim of the present study is to derive a new line...

Open access Research Article 10.9734/jpri/2021/v33i62A35550

Method Development, Validation and Degradation Studies of Imatinib Mesylate by UPLC

Punna Venkateshwarlu & Mehul M. Patel · Journal of Pharmaceutical Research International · 2021

Background: A simple, reliable and economical method was used for the study of imatinib mesylate.  The optimized chromatographic conditions were determined by using a C18 intersil ODS (250 X 4.6 mm X 5µm) and a mobile phase containing phosphate buffer (pH 3.0): Acetonitrile: Meth...

Open access Research Article 10.9734/jpri/2021/v33i62A35541

Structure Based Drug Discovery, Docking, Modelling, Synthesis and Anticancer Screening of Some Novel Quinoline Derivatives

Bharat Shivaji Honde & Kunkulol Rahul Rajendra · Journal of Pharmaceutical Research International · 2021

A new series of (2-(substituted-phenyl) quinoline-4-yl) (3-(substituted phenyl)-5-phenyl-1H-pyrazol-1-yl) methanone derivatives was carried out docking modelling and synthesized. Purity was checked by TLC and chemical structures of synthesized compounds were elucidated by their I...

Open access Research Article 10.9734/jpri/2021/v33i62A35384

Effect of Virgin Coconut Oil in Plaque Related Gingivitis

V. S. Rakshitha, A. Jothi Priya & R. Gayatri Devi · Journal of Pharmaceutical Research International · 2021

Introduction: In all individuals oral health is important. Irrespective of nationality, oral hygiene habits are taught in childhood itself. Tooth cleaning by the mechanical method is the most accepted method in the maintenance of oral hygiene worldwide. Presently to reduce plaque...

Open access Research Article 10.9734/jpri/2021/v33i62A35553

Hepatoprotective Activity of Pongamia Pinnata Leaves on Antitubercular Drugs (Isoniazid & Rifampin) Induced Hepatotoxicity in Rats

Samba Siva Raju Derangula, N. S. Muthiah, H. S. Somashekar, E. Sukumar & K. Prabhu · Journal of Pharmaceutical Research International · 2021

Hepatoprotective effect of an ethanolic extract of Pongamia Pinnata on antitubercular drugs (isoniazid and rifampin) induced hepatotoxicity in rats. Methods: The experiment used five groups of male wistar rats, each with six individuals. The two control groups were given gum acac...

Open access Research Article 10.9734/jpri/2021/v33i62A35555

Anti- Diabetic and Cytotoxic Effect of Zinc Oxide Nanoparticles Synthesised Using Boerhaavia diffusa

M. B. Sai Keerthana, Lakshminarayanan Arivarasu, S. Rajesh Kumar & Lakshmi Thangavelu · Journal of Pharmaceutical Research International · 2021

Introduction: Nanotechnology is the art of manipulating matter in terms of nano scale. It mainly aims at combining nanotechnology with drugs to improve the ability of a specific target. These materials are produced at nanoscale level as it is safe to administer in the body. Boerh...

Open access Research Article 10.9734/jpri/2021/v33i62A35611

Preparation of Ethanolic Extract of Cassia auriculata and Its Anti-Diabetic Activity

T. Srinivasa Surya Sitaram, Lakshminarayanan Arivarasu, S. Rajeshkumar & Lakshmi Thangavelu · Journal of Pharmaceutical Research International · 2021

Introduction: Diabetes has caused a major burden to the health sector in the developing countries and has shown an increasing trend among the urban population. It is estimated that most patients are with type II diabetes which could be easily treated with dietary changes, exercis...

Open access Research Article 10.9734/jpri/2021/v33i62A35612

Evaluation of Antitumour Activity of Ethanolic Extract from Tribulus terrestris in Human Breast Cancer Cells

M. Kamalli, S. Raghunandhakumar, D. Ezhilarasan & T. Lakshmi · Journal of Pharmaceutical Research International · 2021

Introduction: Breast cancer is the form of cancer that occurs in the breast cells. After skin cancer, breast cancer is considered to be the most common cancer diagnosed in women. The number of deaths associated with this disease was increased in case of lack of early detection. T...

Open access Research Article 10.9734/jpri/2021/v33i62A35613

Anti-Inflammatory Activity of Cassia auriculata Flower Extract

Soorya Ganesh, Lakshminarayanan Arivarasu, S. Rajeshkumar & Lakshmi Thangavelu · Journal of Pharmaceutical Research International · 2021

Introduction: Medicinal plants have provided recent medicines with numerous plant derived therapeutic agents. Avaram is extremely valued in Indian medicines for management of painful inflammation and diabetes. The target of this study was to measure the anti-inflammatory potentia...

Open access Research Article 10.9734/jpri/2021/v33i62A35614

Prevalence of Clinically Missing Permanent Teeth Due to Agenesis and Secondary Factors among Patients between 8-17 Age Group Visiting a Private Dental Hospital - an Institutional Study

S. Padmaja, Pratibha Ramani & P. K. Reshma · Journal of Pharmaceutical Research International · 2021

Introduction:  Congenitally missing teeth or hypodontia is a condition where some of the adult teeth fail to develop. There have been theories involving genetic and environmental factors which lead to prevalence of permanent missing teeth. Missing teeth can affect the patients an...

Open access Research Article 10.9734/jpri/2021/v33i62A35615

Antioxidant and Antiinflammatory Activity of Titanium Dioxide Nanoparticles Synthesised Using Mucuna pruriens

B. Sachin Aditya, Lakshminarayanan Arivarasu, S. Rajeshkumar & Lakshmi Thangavelu · Journal of Pharmaceutical Research International · 2021

Introduction: The genus Mucuna, belonging to the Fabaceae family, sub family Papilionaceae, includes approximately 150 species of annual and perennial legumes. Titanium dioxide (TiO2) nanoparticles (NPs) are manufactured worldwide in large quantities for use in a wide range of ap...

Open access Research Article 10.9734/jpri/2021/v33i62A35616

Evaluation of Anti-Cancer Activity of Saraca asoca Flower Extract against Lung Cancer Cell Line

A. Divya Dharshini, P. Elumalai, S. Raghunandhakumar, T. Lakshmi & Anitha Roy · Journal of Pharmaceutical Research International · 2021

Lung cancer is the second most common type of cancer, affecting one out of every five men and one out of every nine women. Lung cancer treatment is dictated by the cell type of the cancer, the amount to which it has spread, and the patient's overall condition. It is well known th...

Open access Research Article 10.9734/jpri/2021/v33i62A35617