For providing treatment about most complex disease like cancer, hormone inadequacy, kidney problems, life-threatening and many types of rare illnesses biologics are conducting a major role of the biopharmaceutical market. But there are many problems faces that’s are a highly comp...
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Research Article10.9734/jpri/2024/v36i127639
Introduction: Ledipasvir/sofosbuvir is a fixed-dose combination of two antiviral drugs with different mechanisms of action. It is used to treat chronic hepatitis C genotype 1 infection in adults as a fixed-dose combination tablet containing 90 mg ledipasvir and 400 mg sofosbuvir....
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Research Article10.9734/jpri/2024/v36i127638
Introduction: Neurotoxicity refers to the harmful effects of chemical, biological, or physical agents on the nervous system. Acetaminophen, a common pain reliever whose abuse has been linked to neurotoxicity at high doses, causing oxidative stress and neuronal damage. Aim: The pr...
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Research Article10.9734/jpri/2024/v36i127637
The seasonal and annual variation of the equatorial electrojet strength at Addis Ababa and Mbour during the ascending phase of solar cycle 24 has been investigated. We used magnetic field measurements obtained from International Real-time Magnetic Observatory Network (INTERMAGNET...
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Research Article10.9734/iaarj/2024/v6i1107
Hani Raka Karrar, Mahmoud Ismail Nouh, Maria Talal Kufyah, Amal Mueidh Alshehri, Rahaf Mohammed Zuhair, Ahad Hamdi Alanazi, Faisal Abdulrahman Alahmari, Mohammed Yahya Bakhan Alqarni, Saleh Jabbar Saleh Alzahrani, Amera Gassem Ghzwani, Abdulrahman Olayan Almuqati, Muhannad Ibrahim Aldhuwayhi, Turki Othman Ali Alharbi & Khloud Mubark Alotaibi·Journal of Pharmaceutical Research International·2024
T-cell acute lymphoblastic leukemia (T-ALL) represents a highly aggressive hematological malignancy predominantly affecting adolescents and young adults. Despite advancements in treatment modalities, including multi-agent chemotherapy, the prognosis remains unfavorable, particula...
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Research Article10.9734/jpri/2024/v36i127636
The increasing prevalence of obesity highlights the urgent need for effective and sustainable management solutions. This review explores how nutraceuticals derived from various sources can play a key role in addressing obesity and its related health issues. Compounds like curcumi...
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Research Article10.9734/jpri/2024/v36i127635
Introduction: Dutasteride, a synthetic 4-azasteroid belonging to the class of 5-α-reductase, a BCS class II drug, is used in treating Androgenetic Alopecia and Benign Prostatic Hyperplasia. Aims: The study aims to formulate, evaluate and perform stability studies of Dutasteride-l...
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Research Article10.9734/jpri/2024/v36i127633
The illicit use of anabolic androgenic steroids (AAS) poses a significant global health challenge, particularly due to the widespread availability of counterfeit products in underground markets. This review examines AAS seized in Brazil, a country with a notable prevalence of use...
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Research Article10.9734/jpri/2024/v36i127634
The primary aim of this study is to investigate the longitudinal morphology of the Morning Counter-Equatorial Electrojet (MCEJ) during a period of low solar activity (specifically, the year 2008). The study employed a comparative longitudinal analysis of the Morning Counter-Equat...
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Research Article10.9734/iaarj/2024/v6i1106
Parenteral Nutrition (PN) is a critical therapeutic technique that delivers necessary nutrients straight into the circulation, bypassing the gastrointestinal system. This strategy is critical for people who are unable to acquire appropriate nourishment through oral or enteral rou...
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Research Article10.9734/jpri/2024/v36i127632
Aims: To identify and record adverse effects/adverse drug reactions in patients receiving pharmacotherapy for obsessive compulsive disorder (OCD) visiting Psychiatry Out patient department of King George’s Medical University, Lucknow and to assess the causality of adverse drug re...
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Research Article10.9734/jpri/2024/v36i127631
This comprehensive guide provides a detailed comparison of analytical method validation requirements across four major regulatory bodies: the International Council for Harmonisation (ICH), United States Pharmacopeia (USP), Chinese Pharmacopoeia (ChP), and Brazilian Health Regulat...
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Research Article10.9734/jpri/2024/v36i127628
Aim: To evaluate the antidiabetic potential of Putranjiva roxburghii leaves using In vitro models, focusing on their ability to inhibit key enzymes involved in carbohydrate metabolism. Study Design: The current research program is an attempt to screen In vitro anti-diabetic activ...
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Research Article10.9734/jpri/2024/v36i127629
Ketoprofen, a widely prescribed non-steroidal anti-inflammatory drug (NSAID), suffers from limited oral bioavailability due to poor solubility and a short half-life, leading to frequent dosing and potential gastric irritation. This review examines recent advancements in oral Keto...
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Research Article10.9734/jpri/2024/v36i127630
Orotransmucosal drug delivery is an alternative method used for a systemic drug delivery system. It is used as a favored route for non-parenteral administration of emergency drugs and agents. It can be used both for lipid-soluble and water-soluble drugs. It increases drug solubil...
Open access
Research Article10.9734/jpri/2024/v36i127627