Histone deacetylase (HDAC) inhibitors have emerged as promising therapeutics for various cancers due to their ability to modulate gene expression profiles and restore normal cellular functions. Among the key targets of HDAC inhibitors are tumor suppressor genes, which play crucia...
Open access
Research Article10.9734/jpri/2024/v36i117596
Objective: To explore the role of "Preventive Treatment of Disease" from Traditional Chinese Medicine in public health emergencies. To narrow the differences between Chinese and Western medicine's prevention and treatment strategies in public health emergencies and to better inte...
Open access
Research Article10.9734/jpri/2024/v36i107594
Our bodies generate many structures that are eventually destroyed, such as the webbing between digits in a fetus, nerve cells that cannot identify target cells during development, and cells that are recruited during an immune response. Our bodies constantly replace their cells. T...
Open access
Research Article10.9734/jpri/2024/v36i107595
We report here the design of new inhibitors against human monoamine oxidase (hMAO-B) as potential treatment of Parkinson’s disease. We have completed computer-aided molecular design of MAO-B inhibitors by In situ modification of the reference crystal structure of 7-(3-chlorobenzy...
Open access
Research Article10.9734/jpri/2024/v36i107592
In the realm of maxillofacial medicine, osteomyelitis, a disorder marked by inflammation of the bone and bone marrow, presents serious challenges. Even though the medical community is aware of this disorder, it is relatively prevalent, especially in developing nations like India,...
Open access
Research Article10.9734/jpri/2024/v36i107593
Syed Taimoor Tayyab, Wasta Aslam Gill, Mavra Siddique, Minahil Nasir, Arooj Arif, Esha Khan, Arisha Saghir, Hasnat Rafique, Ameer Hamza & Muhammad Zahid Iqbal·Journal of Pharmaceutical Research International·2024
Background: Gouty arthritis is a prevalent but frequently misdiagnosed condition particularly in developing countries. As a medical expert pharmacists are essential to patient medication management, patient education, and treatment protocol adherence but insufficient information...
Open access
Research Article10.9734/jpri/2024/v36i107590
Mahnoor Ch, Minahil Zaman, Samra Abdul Rauf, Zaki Ullah Mairaj, Laiba Jamil, Samra Essa, Noor-e-Hizba Chaudhary, Mehr-un-nisa, Javeria Riaz & Muhammad Zahid Iqbal·Journal of Pharmaceutical Research International·2024
Background: Community pharmacies are the integral part of the healthcare system offering healthcare services for patients. Pharmacists are expanding their roles by providing pharmaceutical services and comprehensive pharmaceutical care. Health screenings played an important role...
Open access
Research Article10.9734/jpri/2024/v36i107591
Gulzaib Bibi, Huzaima Shahzadi, Ayesha Nadeem, Muneeba Naveed, Laraib Abid, Jawaria Nazeer, Asfa Iqbal, Tasmia Munir, Tahreem Afzaal, Zarqa Saqib, Ayesha Zulfiqar Ali & Muhammad Zahid Iqbal·Journal of Pharmaceutical Research International·2024
Background: Corticosteroids are a class of steroid hormones produced by the adrenal gland and are used to treat many diseases, including autoimmune diseases and inflammatory diseases. Besides their role in many diseases, long-term use, misuse, and overuse cause side effects inclu...
Open access
Research Article10.9734/jpri/2024/v36i107589
In our study, we explored the properties of a spatially homogeneous and anisotropic Bianchi type V I0 Universe. Our investigation centered on integrating cosmic domain walls into the f(R, T) theory of gravitation, initially proposed by Harko et al. (2011). To tackle the field equ...
The small mammalian labratory animals, the mice and the rabbits were tempted to be pathogenicity models for S. pneumoniae serotypes 1 and 6, the infecting doses were 0.3ml for mice and 0.5 ml for rabbits. These infectious doses were rated to a count of 1X 10 to 7 CFU/ml. The infe...
Open access
Research Article10.9734/jpri/2024/v36i107588
In this study we investigated half-heusler alloy (NaCrSb) using density functional theory as implemented in Quantum espresso software version qe-6.8 for simulation on ubuntu operating system version 22.04LTS. The Perdew-Burke-Ernzerhof (PBE) generalized gradient approximation (GG...
Background: Healthcare providers, including pharmacists who prescribe medications, have a professional obligation to select treatments that are in the best interests of their patients. Consequently, the concept of off-label drug use, where drugs are used outside their approved in...
Open access
Research Article10.9734/jpri/2024/v36i107587
Dyslipidemia has been linked to insulin resistance and hyperglycemia. Hyperglycemia, which is the outcome of either insufficient insulin production or insensitivity to insulin, is the hallmark of diabetes mellitus (DM). In this study, thirty-six (36) male Wistar rats with diabete...
Open access
Research Article10.9734/jpri/2024/v36i107586
Background: Hypertension is the primary contributor to cardiovascular diseases worldwide, it affects millions and needs effective management strategies. Pharmacist-led Medication Therapy Management (MTM) is essential in improving medication adherence and optimizing the treatmen...
Open access
Research Article10.9734/jpri/2024/v36i107584
The U.S. Food and Drug Administration (FDA) plays a crucial role in safeguarding public health by regulating pharmaceutical and medical device industries. Warning letters issued by the FDA serve as a critical tool for enforcing regulatory compliance and highlighting significant v...
Open access
Research Article10.9734/jpri/2024/v36i107585