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GC-MS Analysis and Wound Healing Efficiency of Ethanolic Leaves Extract of Cassia occidentalis and Pithecellobium dulce in Wistar Albino Rats: Comparative Study

B. Rajarajeswari, B. Praveen Kumar & Amrutha V. Audipudi · Journal of Pharmaceutical Research International · 2021

Aim: To identify and compare the bioactive compounds in the ethanolic leaves extracts of Cassia occidentalis and Pithecellobium dulce and to evaluate the wound healing efficiency in Wistar Albino rats. Study Design: The leaves ethanolic extracts was analysed by GC-MS and the extr...

Open access Research Article 10.9734/jpri/2021/v33i44A32602

Stability Demonstrating Validated High Pressure Liquid Chromatographic Method for the Determination of Trilaciclib in Bulk and Pharmaceutical Formulation

Syed. Rafi & Kantipudi Rambabu · Journal of Pharmaceutical Research International · 2021

Aims: New validated method for the estimation of  Trilaciclib using HPLC and study of its degradation Place and Duration of Study: Department of Chemistry, RVR & JC College of Engineering, Chowdavaram, Guntur, Andhra Pradesh, between February 2021 and August 2021. Methodology...

Open access Research Article 10.9734/jpri/2021/v33i44A32604

Comparative Evaluation on the Expression of Pi3 Kinase - AKT- mTOR Signalling Molecules in Oral Squamous Cell Carcinoma - A Real Time PCR Based Approach

Krishnapriya Umashankar, J. Selvaraj & Pratibha Ramani · Journal of Pharmaceutical Research International · 2021

Background: Oral squamous cell cancer (OSCC) develops as a result of the accumulation of many genetic mutations that are influenced by genetic predisposition. Upon acquisition of genetic predisposition, the precancerous cells will transform into malignant cells culminating into c...

Open access Research Article 10.9734/jpri/2021/v33i44A32605

RP-HPLC Method for Quantification of Emtricitabine and Tenofovir Alafenamide Fumarate Drug Substance and Tablet Dosage Form

P. Sunand Sarat & D. Ramachandran · Journal of Pharmaceutical Research International · 2021

Aim: The primary objective of the research work is to develop a effective, sensitive, economical and simple reverse phase HPLC method to estimate Emtricitabine and tenofovir alafenamide fumarate in its pure and binary mixture of tablets. Study Design: HPLC based Quantification St...

Open access Research Article 10.9734/jpri/2021/v33i44A32606

Determination of Pickering Nanoemulsion by Eudragit Rl-100 Nanoparticle as Oral Drug Delivery for Poorly Soluble

Ashish Y. Pawar, Khanderao R. Jadhav, Sagar S. Patil & Pallavi R. Jadhav · Journal of Pharmaceutical Research International · 2021

Objective: The purpose of this research study was to develop Ketoprofen-loaded Pickering nanoemulsion with the help of polymeric nanoparticles [NPs]. The pickering nanoemulsion  formulation is developed using Eudragit RL 100, which has the greater ability to stabilize the formula...

Open access Research Article 10.9734/jpri/2021/v33i44A32607

Comparison of Prescribing Errors in Different Wards of Tertiary Care Hospital before and after Implementation of CPOE System

Imran Qureshi, Mirza Tasawer Baig, Uzma Shahid, Ambreen Huma, Aisha Jabeen, Muneeza Lodhi, Aslam Shah, Hirra Soomro, Muhammad Asad Mehdi & Asma Sajid · Journal of Pharmaceutical Research International · 2021

Background: Medication prescribing errors were always known as inevitable errors in health care system which mainly includes physician’s writing error which then leads to wrong dispensing error. Manual Prescribing has now shifted to CPOE System that seems to be more efficient. Th...

Open access Research Article 10.9734/jpri/2021/v33i44A32609

Clinical Features, Diagnosis and Treatment Strategies of Limb Girdle Muscular Dystrophy: An Observational Study from South India

S. Nigama Chandra, A. Anka Rao, G. S. N. Koteswara Rao, K. Umasankar & A. Rajasekhar Reddy · Journal of Pharmaceutical Research International · 2021

Objective: The present observational study describes the natural course of clinical features, family history, and diagnosis pattern and treatment strategies in rare genetic disorder, Limb girdle muscular dystrophy (LGMD). Research Design: Observational study Methods: Clinically/I...

Open access Research Article 10.9734/jpri/2021/v33i44A32610

Design Space by Design of Experiments

Sushant Dangat, Deep Patel & Ashwin Kuchekar · Journal of Pharmaceutical Research International · 2021

The quality of methods and products are usually influenced by several input factors. Research has recently focused on understanding the effects of multidimensional and interconnected input factors on the results of pharmaceutical products and analytical methods using Design of Ex...

Open access Research Article 10.9734/jpri/2021/v33i44A32584

Severe Acute Respiratory Infection: A Case Report

Julie Vanlalsawmi, Mayur Wanjari, Sagar Alwadkar & Deeplata Mendhe · Journal of Pharmaceutical Research International · 2021

Introduction: Severe Acute Respiratory Infection (SARI) is a disease of the respiratory system. It is a symptomatic disease with different types of causative agent, and whose definite treatment and cure depends on the type of pathogens, nature of onset, severity of symptoms and t...

Open access Research Article 10.9734/jpri/2021/v33i44A32586

Hot Melt Coating: Development and Optimization of Controlled Release Formulation and Process of Oxcarbazepine

Nilam Patel & Rupal Jani · Journal of Pharmaceutical Research International · 2021

Hot-melt coating process (HMCP) is being developed to formulate lipid based oral controlled release formulation system for anti-epileptic drug Oxcarbazepine. Pellets containing Active ingredient in the core portion were prepared by extrusion spheronization process with use of app...

Open access Research Article 10.9734/jpri/2021/v33i44A32588

Insight Cross-talk between p53 and Toll-like Receptor

Mohammad Jahoor Alam, Fevzi Bardakci, Sadia Anjum, Shumayla Rasheed Mir, Irfan Ahmad, Mohd Faisal & Mohd Saeed · Journal of Pharmaceutical Research International · 2021

Toll-like receptors (TLR) are one of the most-studied receptors for their role in innate immunity. TLRs are reported to binds with conserved pathogen-associated molecular patterns (PAMPS). TLRs and PAMPS interaction leads to several downstream proteins' activation, which further...

Open access Research Article 10.9734/jpri/2021/v33i44A32587

Squamous Odontogenic Tumor of Posterior Maxilla-A Report of a New Unusual Case & Literature Review

Sandeep S. Sihmar, Karthikeyan Ramalingam, Shalini Rathi & Abhishekh kumar · Journal of Pharmaceutical Research International · 2021

Squamous odontogenic tumor is a benign epithelial odontogenic tumor that is very unusual in the maxilla & mandible. Mostly, these are present as single lesions, but rarely they can be multifocal lesions. The nature of maxillary lesions is more aggressive. Because of their ben...

Open access Research Article 10.9734/jpri/2021/v33i43B32571

Review for Analytical Methods for the Determination of Mefenamic Acid

T. V. Ashira, T. Mohamed Rafeeque, Saba Maanvizhi, S. Kathirvel, P. C. Indukala & S. Safeetha · Journal of Pharmaceutical Research International · 2021

Mefenamic acid (MFA) is a non-steroidal anti-inflammatory drug that belongs to the anthranilic acid derivative family. It is used to relieve mild to moderate pain. The present review article includes a compilation of articles on the various properties along with an extensive lite...

Open access Research Article 10.9734/jpri/2021/v33i43B32572

Health in Digital World: A Regulatory Overview in United States

Ashutosh Mishra, M. P. Gowrav, V. Balamuralidhara & Kolli Suhas Reddy · Journal of Pharmaceutical Research International · 2021

Adaptation towards digitalization in pharmaceuticals leads to the utilization and development of Artificial Intelligence (AI). Significantly it is reducing human workload with the help of an algorithm. Already AI is acting as a key in clinical trial, health care, quality manageme...

Open access Research Article 10.9734/jpri/2021/v33i43B32573