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Unveiling the Hidden Therapeutic Potential of Epipremnum aureum: A Review of Phytochemistry and Pharmacological Insights

Guruprasad Sutar, Mahesh Mali, Prakash Nargatii, Rajkumar Bagali, Sourabh Khot & Mahesh Saralaya · Journal of Pharmaceutical Research International · 2026

Background: Epipremnum aureum is widely recognized in traditional medicine for its diverse therapeutic properties. Recent research has focused on its phytochemical richness and potential biomedical applications, particularly in hepatoprotection and nanotechnology-based formulatio...

Open access Research Article 10.9734/jpri/2026/v38i77852

Artemisia pallens Wall. Ex Dc. (Davana): Phytochemistry, Traditional Uses, Pharmacological Activities, Safety Profile and Future Prospects: A Comprehensive Review

Guruprasad Sutar, Ashish Shelar, Rajkumar Bagali, Prakash Nargatti, Sachin Sajane, Mahesh Saralaya & Sourabh Khot · Journal of Pharmaceutical Research International · 2026

Background: Artemisia pallens, commonly known as davana, is an aromatic medicinal herb belonging to the Asteraceae family and is native to India. The plant has been traditionally used in Ayurvedic and folk medicine for the treatment of various ailments and is also valued in the p...

Open access Research Article 10.9734/jpri/2026/v38i77853

Investigating the Effect of Benfotiamine in Paclitaxel-induced Peripheral Neuropathy

Haritha Pasupulati, Satyanarayana SV Padi, Sujatha Dodoala & Prasad VSRG Koganti · Journal of Pharmaceutical Research International · 2026

Background: Chemotherapy-induced peripheral neuropathy (CIPN), particularly due to paclitaxel, remains a dose-limiting adverse effect. Benfotiamine, a lipid-soluble thiamine precursor, has shown anti-inflammatory, antinociceptive, and neuroprotective effects experimentally. Objec...

Open access Research Article 10.9734/jpri/2026/v38i67851

Therapeutic Potential of Hedychium coronarium: Integrating Phytochemistry, Pharmacology, and Antidiabetic Mechanisms

Sachin Sajane, Rajeshwari Sawant, Prakash Nargatti, Rajkumar Bagli, Guruprasad Sutar, Shagufta Naikawadi & Mahesh Saralaya · Journal of Pharmaceutical Research International · 2026

Background: Hedychium coronarium J. Koenig is a monocotyledonous perennial herb belonging to the family Zingiberaceae and genus Hedychium. It is commonly known as butterfly ginger, garland flower, butterfly lily, and cinnamon jasmine. The plant is widely distributed in tropical a...

Open access Research Article 10.9734/jpri/2026/v38i67850

Outpatient Pediatric Antibiotic Prescribing Practices Based on the WHO Access, Watch, and Reserve (AWaRe) Framework

David Raj Edla, Haritha Pasupulati & Satyanarayana SV Padi · Journal of Pharmaceutical Research International · 2026

Background: Children's unique growth and weakened immune systems make them more vulnerable to infections, particularly upper respiratory tract infections. Notably, inappropriate antibiotic prescribing patterns are mainly due to nonprescription use, overuse and misuse of antibioti...

Open access Research Article 10.9734/jpri/2026/v38i67849

Colistin Resistance in Gram Negative Pathogens: Mechanisms, Detection, Therapeutic Challenges and Future Perspectives

P S Athira, G Bhavani, K S Harishkumar & K.S. Sridevi Sangeetha · Journal of Pharmaceutical Research International · 2026

Colistin is widely regarded as a last-resort therapeutic option for infections caused by multidrug-resistant Gram-negative bacteria. In recent years, the global rise of colistin resistance among Gram-negative isolates has become a significant public health concern. Colistin resis...

Open access Research Article 10.9734/jpri/2026/v38i67848

Design and Biological Potential of New 6-Aryl-2-(4-(1,3-dioxoisoindolin-2-yl) phenyl)imidazo(2,1-b)1,3,4-thiadiazoles: Synthesis and Molecular Docking Studies

Patel Mayurkumar Manchharam & R. N. Patel · Journal of Pharmaceutical Research International · 2026

By cyclocondensing 4-(1,3-dioxoisoindolin-2-yl)benzoic acid with thiosemicarbazide to form a crucial intermediate and then reacting with different substituted phenacyl chlorides, a novel series of 6-aryl-2-(4-(1,3-dioxoisoindolin-2-yl)phenyl)imidazo(2,1-b)1,3,4-thiadiazoles (3a-3...

Open access Research Article 10.9734/jpri/2026/v38i67844

Comparative Evaluation of Bracket Positioning Accuracy Using MBT Gauge and MGBP Positioner: A Split-mouth Clinical Study

Himanshu Kumar Sah, Tanusha Mahobia, Javed Sodawala, Piyush Khandelwal, Rudra Pratap Singh Thakur, Sonam Parakh & Jyoti Panjwani · Journal of Pharmaceutical Research International · 2026

Background: Accurate bracket placement is essential for achieving optimal orthodontic treatment outcomes. Errors in vertical or axial positioning can alter torque expression, tip, and in–out relationships, thereby affecting the final occlusal result. Although several gauges assis...

Open access Research Article 10.9734/jpri/2026/v38i67845

Assessment and Analysis of Knowledge and Medication Adherence in Patients with Hypertension

N. C. Sowndharya, Harshitha S. Surya, S. Madan, N. R. Abhishek & B. Shashank · Journal of Pharmaceutical Research International · 2026

Objective: Hypertension is a chronic condition that requires long-term management. Successful control of blood pressure largely depends on patient awareness and adherence to prescribed medication. This study was designed to assess the level of knowledge and medication adherence i...

Open access Research Article 10.9734/jpri/2026/v38i67846

From Ethnomedicine to Evidence-Based Therapeutics: Phytoconstituents and Bioefficacy of Euphorbia pulcherrima

Sachin Sajane, Madhura Kumbhar, Rajkumar Bagali, Prakash Nargatti, Guruprasad Sutar, Satyaraj Ombase & Mahesh Saralaya · Journal of Pharmaceutical Research International · 2026

Background: Euphorbia pulcherrima, also known as poinsettia, is a medicinally significant decorative plant that has long been used for managing wounds, skin conditions, respiratory conditions, and inflammation. The plant's therapeutic potential is due to its bioactive phytoconsti...

Open access Research Article 10.9734/jpri/2026/v38i67847

Exploring the Antifungal Effects of Lactiplantibacillus plantarum on Candida albicans: A review

Juel Mariam Mathew, Kusuma S., Leena Bharanim S. R., Sakshee Singh Yadav & Padmashree Kulkarni · Journal of Pharmaceutical Research International · 2026

Candida albicans is one of the major pathogens of concern as an opportunistic fungal organism that is a normal component of the human microbiota. Vulvo vaginal candidiasis is commonly seen in women and can impact up to 75% of women at least once during their lifetime. People with...

Open access Research Article 10.9734/jpri/2026/v38i57842

Postbiotic and Phytochemical Modulation of Multispecies Periodontal Biofilms: Comparative Effects on Biofilm Viability and Porphyromonas Gingivalis Virulence

Mehmet Murat Taşkan, Elif Sirma TASKAN & Özkan Karataş · Journal of Pharmaceutical Research International · 2026

Background: Periodontal diseases are associated with complex multispecies biofilms in which Porphyromonas gingivalis acts as a key virulence-associated pathogen contributing to inflammation and tissue destruction. Owing to the limitations of conventional antimicrobials, postbioti...

Open access Research Article 10.9734/jpri/2026/v38i57843

Evaluation of the Nootropic Activity of the Ethanolic Leaf Extract of Couroupita guianensis in Scopolamine Induced Amnesia Models

Srinivasu Matta, Varri Chandinisaisri, Ummey Kulsum, Vanapalli Kushitha, Dhabal Kumar Satapathy & V. Bhaskararaju · Journal of Pharmaceutical Research International · 2026

Background: Alzheimer’s disease and related cognitive disorders are characterized by progressive impairment of learning and memory, often associated with cholinergic dysfunction. Natural plant-derived compounds are being explored as potential nootropic agents with neuroprotective...

Open access Research Article 10.9734/jpri/2026/v38i57841

Computer-Aided Drug Design Approaches for Benzilic Acid and Benzilate Derivatives: From Muscarinic Antagonists to Scaffold-Centred Workflows

Sipra Sarkar Banerjee, Sougata Kumar Mondal & Snehasis Maiti · Journal of Pharmaceutical Research International · 2026

Benzilic acid (2-hydroxy-2,2-diphenylacetic acid) and its derivatives occupy a distinctive niche in medicinal chemistry because the scaffold naturally combines (i) a bulky, “aryl-rich” hydrophobic domain and (ii) a polar, acid/ester-bearing handle that can be tuned for permeabili...

Open access Research Article 10.9734/jpri/2026/v38i57839

Unveiling the Therapeutic Potential: Cylicodiscus gabunensis (FABACEAE) Aqueous Stem Bark Extract Derived Silver Nanoparticles for Enhanced Anti-inflammation in Wistar Rats

François Eya’ane Meva, Philippe Belle Ebanda Kedi, Agnes Antoinette Ntoumba, Pamela Ngadie Mponge, Juliette Koube, Gildas Fonye Nyuyfoni, Jean Baptiste Hzounda Fokou, Thi Hai Yen Beglau, Alex Kevin Tako Djimefo, Annie Guilaine Djuidje, Geordamie Chimi Tchatchouang, Ariane Laure Wounang, Madeleine Ines Danielle Evouna, Maeva Jenna Chameni Nkouankam, Yolaine Pamela Dada Youte, Bertin Sone Enone & Christoph Janiak · Journal of Pharmaceutical Research International · 2026

Background: Medicinal plants and green-synthesized silver nanoparticles have gained increasing attention as potential alternatives to conventional anti-inflammatory therapies due to their bioactivity, biocompatibility, and reduced toxicity. Aims: The present study investigates th...

Open access Research Article 10.9734/jpri/2026/v38i57840