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All published articles 7450

Post-operative Physiotherapeutic Rehabilitation in a Rare Case of Avulsion Fracture of Tibial Attachment of Posterior Cruciate Ligament: A Case Report

Yukta J. Budhwani, Pratik Phansopkar, Om C. Wadhokar & Neha Chitale · Journal of Pharmaceutical Research International · 2021

Avulsion fractures of tibial attachment of PCL are not observed very often. PCL injuries are uncommon; especially those involving tibial aspect/fragment are rare. On the basis of the site of damage: Hyperflexion, Hyperextension, Pretibial trauma, etc. are the considered causes of...

Open access Research Article 10.9734/jpri/2021/v33i33B31806

Antinociceptive and Anti-Inflammatory Activities of Ethanolic Stem Bark Extract of Smilax zeylanica Linn. in Wistar Rats

Rasheed Ahemad Shaik, Fazil Ahmad & Mohammed Abdul Aleem · Journal of Pharmaceutical Research International · 2021

Background: Smilax zeylanica Linn (Smilaceae) is a woody climbing shrub native to Asia's tropical and subtropical highlands. Traditionally, this plant has been widely used to cure a variety of ailments. Smilax zeylanica stem bark was extracted with ethanol to test its antinocicep...

Open access Research Article 10.9734/jpri/2021/v33i33B31801

Antiparkinsonian Activity of Aqueous Extract of Agaricus Blazei Murill in Rotenone-induced Parkinson’s Disease

Muhammad Aslam, Hammad Ahmed, Tayyaba Mumtaz & Gahzal Hakani · Journal of Pharmaceutical Research International · 2021

Background: Parkinsons disease is a chronic neurological disorder which may be due to reduction in the dopaminergic neurons in the brain. However, Agaricus blazei is a rich source of natural antioxidants. Aim: In this study, antiparkinsonian activity of Agaricus blazei Murill was...

Open access Research Article 10.9734/jpri/2021/v33i33B31803

Comparative Study of Native or Nano Quercetin on Epigenetic Modification and Nephropathy Biomarkers Post Challenges in Diabetic Hamsters

Soha Shebel Nassar, Mona Ahmed Sadek, Huda Mohamed Ismail & Gehan Salah El-Din Moram · Journal of Pharmaceutical Research International · 2021

Aims: The aim of this study is to examine the regulatory effects of quercetin nanoparticles (QNPs) compared with native quercetin either with or without metformin against the abnormal molecular and biochemical pathways that eventually culminate in the pathologic condition clinica...

Open access Research Article 10.9734/jpri/2021/v33i33B31805

Analysis of Predictors of 30-Day Mortality for Patients Undergoing Surgical Repair of Post-Myocardial Infarction Ventricular Septal Defect

Yelizaveta Lebedieva, Chacón-Lozsán Francisco, Ramil Aliyev & Mykhailo Grusha · Journal of Pharmaceutical Research International · 2021

Aims: Despite the existence of numerous studies devoted to predictors of 30-day mortality in patients with post-myocardial infarction (MI) ventricular septum defect (VSD), the choice of surgical treatment tactics for post-MI VSD remains an item of discussion. The purpose of the r...

Open access Research Article 10.9734/jpri/2021/v33i33B31807

A Cross-Sectional Questionnaire-Based Study to Find Out the Knowledge and Awareness of Community Pharmacist and Physician about Drug Information Center (DIC) and Its Services

Rajesh Hadia, Rushabh Shah, Jahnvi Parikh, Jisa Johnson, Anchu Marry Thomas, Niraj Pandit, Trupal Rathod, Dhaval Joshi, Sunil Baile & Kushalkumar Gohel · Journal of Pharmaceutical Research International · 2021

Background: Drug information centre (DIC) is a facility specially developed to provide relevant, accurate and unbiased drug information (DI) to consumer and health care professionals regarding the proper use of the drugs, drug safety and all the critical problems regarding the dr...

Open access Research Article 10.9734/jpri/2021/v33i33B31809

Disease Diagnosis System using Machine Learning

Shailesh D. Kamble, Pawan Patel, Punit Fulzele, Yash Bangde, Hitesh Musale & Saipratik Gaddamwar · Journal of Pharmaceutical Research International · 2021

The efficient use of data mining in virtual sectors such as e-соmmerсe, and соmmerсe has led to its use in other industries. The mediсаl environment is still rich but weaker in technical analysis field. There is а lot of information that саn оссur within mediсаl systems. Using po...

Open access Research Article 10.9734/jpri/2021/v33i33B31810

The Correlation between Gene Expression and DNA Methylation Levels of RAS p21 Protein Activator 3 (RASA3) Gene in Saudi Autistic Children

Aisha Alrofaidi, Rawan Saeed Alghamdi, Mona Alharbi, Khloud Algothmi, Reem Farsi, Najla Alburae, Magdah Ganash, Fatemah Basingab, Sheren Azhari, Heba Alkhatabi, Aisha Elaimi, Manal Shaabad, Ashraf Dallol, Amany Alqosaibi, Mohammed Jan, Hesham Aldhalaan & Safiah Alhazmi · Journal of Pharmaceutical Research International · 2021

The potential role of DNA methylation pattern in autism has been provided by revealing the differences in methylation level of multiple genes which are significantly associated with their expression and implicated in ASD pathogenesis. RASA3 is a member of GTPase-activating protei...

Open access Research Article 10.9734/jpri/2021/v33i33B31794

Study to Determine the Efficacy of Illizarov Fixator for the Treatment of Complex Tibial Plateau Fractures

Tanveer Afzal, Niaz Hussain Keerio, Muhammad Rafique Joyo, Nizam Ahmed, Ghazanfar Ali Shah, Aftab Alam Khanzada & Syed Shahid Noor · Journal of Pharmaceutical Research International · 2021

Aim: To evaluate the results of illizarov external fixation using ligamentotaxis technique in high-energy plateau fractures of the tibia. Methodology: The external fixation of illizarov external fixation using ligamentotaxis was performed in 32 patients aged 18-50 years due to hi...

Open access Research Article 10.9734/jpri/2021/v33i33B31795

Comparative Study between Saffron (Crocus sativus L.) and / or Turmeric (Curcuma longa L.) Extracts on D-galactose Deleterious Brain Effects in Rats

Fatma Hussien Ahmed, Kout Elkoloub Baker & Alyae M. S. Gabal · Journal of Pharmaceutical Research International · 2021

Aims: This study was designed to investigate the active chemical constituents and antioxidant capacities of saffron stigmas and turmeric rhizomes ethanolic extracts (ESE and ETE) respectively. D- galactose deleterious brain effects as well as the role of ESE and ETE supplementati...

Open access Research Article 10.9734/jpri/2021/v33i33B31796

Cardiosurgical Care in Case of Congenital Heart Defects: Modern Approaches and Features of the State of Patients' Health

Linda Anzorovna Enginoeva, Isa Shapievich Gaidarov, Djeneta Reyzulahovna Mirzebalaeva, Tatiana Timokhina, Fedorina Alena Georgievna & Aleksandra Alekseevna Sokolova · Journal of Pharmaceutical Research International · 2021

Congenital heart defects today, despite the early intrauterine diagnosis, are still quite common, and their danger to the patient's health is significant. The article discusses the features and modern approaches to the provision of cardiac surgical care for this congenital diseas...

Open access Research Article 10.9734/jpri/2021/v33i33A31790

Role of Panretinal Photocoagulation in Improvement of Visual Acuity of Patients with Proliferative Diabetic Retinopathy

Shabeer Ahmed Bhutto, Zakaullah Gopang, Safder Ali Abbasi, Naeem Akhtar Katpar, Muhammad Yusuf Depar & Vijay Nagdev · Journal of Pharmaceutical Research International · 2021

Objective: To determine the improvement of visual acuity in patients having proliferative diabetic retinopathy undergoing panretinal photocoagulation therapy. Study design: This is a descriptive case series study. Setting: Study carried out at Ophthalmology Department, ShaheedMoh...

Open access Research Article 10.9734/jpri/2021/v33i33A31788

Study of the Association between Serum Ferritin Levels and HbA1c in Patient with Type 2 Diabetes Mellitus in Jordanian Population Sample

Saad AL-Fawaeir, Haytham M. Daradka & Ali Ahmad Abu Siyam · Journal of Pharmaceutical Research International · 2021

Background/ aim: The most common endocrine disorder in the world is type 2 DM, affecting 85-90% of all people with diabetes. Several studies have found an association between serum ferritin levels and HbA1c, so the current study was undertaken to examine the association between s...

Open access Research Article 10.9734/jpri/2021/v33i33B31791

Antiplatelet Agents Utilization Pattern and Assessment of Patient Specific Drug use Problems among Cardiac Patient

Rajesh Hadia, Priyanshi Shah, Johncy Mariam John, Rutvi Patel, Kushal kumar Gohel, Cinosh Mathew, Trupal Rathod, Dhaval Joshi & Rajesh Maheshwari · Journal of Pharmaceutical Research International · 2021

Background: Antiplatelet agents reduce the occurrence of the cardiovascular issue in people with established cardiovascular disease. Objective: To understand the pattern of Antiplatelet drug utilization among cardiovascular disease patients. To evaluate the prevalence of polyphar...

Open access Research Article 10.9734/jpri/2021/v33i33B31792

Assessment of Gene Polymorphism in GABAA1 Receptor among Sudanese Patients with Juvenile Myoclonic Epilepsy (JME)

Sami F. Abdalla, Hanan B. Eltahir & Salah M. El-Magzoub · Journal of Pharmaceutical Research International · 2021

Introduction: Juvenile myoclonic epilepsy (JME) is an idiopathic generalized epilepsy syndrome (IGE) with a strong genetic contribution. The main characters of JME are generalized convulsive or an absences seizures proceeded by myoclonic jerks. Gene variant of gamma-aminobutyric...

Open access Research Article 10.9734/jpri/2021/v33i33B31793