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All published articles 7450

Design, Synthesis and Evaluation of Core Scaffold Pyrazolone Fused Thiazolidinone Derivatives as Anticancer Agents

Sumathy Arunachalam, Suresh Ramalingam, Gowrishankar Narayanasamy Lachmanan & Srinivasan Nagarajan · Journal of Pharmaceutical Research International · 2021

Background: Cancer is the world's second leading cause of death, accounting for an estimate of more than 10 million deaths annually. The most common type of cancers in women are breast, endometrial, cervical, ovarian, colorectal, lung, and skin cancers.Among these, breast cancer...

Open access Research Article 10.9734/jpri/2021/v33i31B31710

Surface Modification of Optimized Asenapine Maleate Loaded Solid Lipid Nanoparticles Using Box-Behnken Design

A. Rekha Devi, M. Vidyavathi & S. P. Suryateja · Journal of Pharmaceutical Research International · 2021

Aim: The aim of the present study was to design and evaluate solid lipid nanoparticles of Asenapine maleate (<2% bioavailability) to enhance its oral bioavailability and surface modification for brain targeting. Methods: A modified solvent injection method was used to produce...

Open access Research Article 10.9734/jpri/2021/v33i31B31706

A Newly Developed Reverse Phase-High Performance Liquid Chromatography Method for the Assay of Dexmethylphenidate and Serdexmethylphenidate with PDA

Subrahmanyam Talari, V. Anuradha, S. N. Murthy Boddapati & Komala Sai Prathuyasa Ayithabotla · Journal of Pharmaceutical Research International · 2021

Aims: The present application is a Newly Validated Reverse Phase-High Performance Liquid Chromatography Method for the Assay of Dexmethylphenidate and Serdexmethylphenidate with PDA. Study design: Mentioned study is a quick, rapid, economical, precise, and accurate reverse phase-...

Open access Research Article 10.9734/jpri/2021/v33i31B31707

Overweight and Obesity Prevalence and Predictors in People Living in Karachi

Sadaf Ibrahim, Zuneera Akram, Aisha Noreen, Mirza Tasawer Baig, Samina Sheikh, Ambreen Huma, Aisha Jabeen, Muneeza Lodhi, Shahzada Azam Khan, Ajmal Hudda, Uzma Shahid & Nayel Syed · Journal of Pharmaceutical Research International · 2021

Objective: This study was aimed to establish the prevalence of overweight, obesity and related its factors among the citizens of Karachi. Methodology: From Jan 2018 to August 2018. This cross-sectional analysis was conducted to obtain information from 772 persons using a validate...

Open access Research Article 10.9734/jpri/2021/v33i31B31708

A Cross-sectional study on Metamemory in Primigravid Women of South Indian population

A. SANGEETHA, G. Priyanka, M. Kumaresan, T. Harshitha & B. Vijayalakshmi · Journal of Pharmaceutical Research International · 2021

Introduction: Metamemory awareness refers to our feelings or experiences of our own memory. For example, if a person feels certain that he or she will remember later something just learned now, that person is having a metamemory experience. Metamemory is a subarea of metacognitio...

Open access Research Article 10.9734/jpri/2021/v33i31B31709

Cubosomes as Potential Nanocarrier for Drug Delivery: A Comprehensive Review

Simran Deep Kaur, Gurdeep Singh, Gurpreet Singh, Keshav Singhal, Shubham Kant & Neena Bedi · Journal of Pharmaceutical Research International · 2021

Lyotropic liquid crystalline cores are characterized as soft nanoparticles and referred as cubosomes.  They are prepared to activate the natural self-assembly capability of lipids (e.g., monoolein or phytantriol) in water. Cubosomes are crystalline isotropic lipidic nanoparticles...

Open access Research Article 10.9734/jpri/2021/v33i31B31698

An Emerging Era for Targeted Drug Delivery: Nanosponges

Akrutiben A. Shah, Ezekiel O. Kehinde & Janki Patel · Journal of Pharmaceutical Research International · 2021

Many forms of Pharmaceutical product like nanosponge, nanoemulsion, nano-micelles, and nanosomes have been developed using nanotechnology. The size of Nanosponges is like that of a virus. They are very tiny in size and can permeate through the skin easily. Nanosponges can be dist...

Open access Research Article 10.9734/jpri/2021/v33i31B31703

Drug Repurposing: A Review

Rani T. Bhagat & Santosh R. Butle · Journal of Pharmaceutical Research International · 2021

The drug development is a very time consuming and complex process. Drug development Process is Expensive. Success rate for the new drug development is very small. In recent years, decreases the new drugs development. The powerful tools are developed to support the research and de...

Open access Research Article 10.9734/jpri/2021/v33i31B31704

Medical Students’ Attitudes and Beliefs toward Chronic Low Back Pain (CLBP) at King Abdulaziz University, Jeddah, Saudi Arabia

Reem Alyoubi, Afnan Alotaibi, Haifa Mohamed, Lama Alghamdi, Nouran Alhumaidi, Roaya Alsulami & Shehana Tayyeb · Journal of Pharmaceutical Research International · 2021

Background: Low back pain (LBP) is one of the most common reasons for long-term disability among the world. Up to 70–85% of people develop a back pain during the course of their lives. It affects people of all ages and is generally caused by sedentary jobs, obesity, smoking and l...

Open access Research Article 10.9734/jpri/2021/v33i31B31695

Use of Virtual Reality (VR) as an Audio-Visual Distraction Tool in the Reduction of Dental Anxiety during Local Anesthesia

Jalison Jacob Cheruvatoor, Lim Kaini, Mohamad Adib Bin Mohd Ali Hanafiah, Muhammad Azizuddin Bin Sihabubdin & Vinay Marla · Journal of Pharmaceutical Research International · 2021

Aims: Dental anxiety is a relatively common problem and it leads to undesirable distresses, such as postponement or avoidance of dental treatment thereby resulting in poorer quality of treatment and reduced oral health related quality of life. Dental anxiety is especially seen in...

Open access Research Article 10.9734/jpri/2021/v33i31B31696

Study of Relationship between Self-rated Health and Objective Health in Different Socio-economic Groups of Tehran in 2014

Fatemeh Khalili, Saharnaz Nejat, Kazem Mohammad, Kamran Yazdani & Ghasem Yadegarfar · Journal of Pharmaceutical Research International · 2021

The evaluation of health by an individual or self-rated health is a popular international index which is widely practiced for evaluating the individuals’ health in the public health researches and epidemiology. Many studies have revealed that self-rated health is a reliable predi...

Open access Research Article 10.9734/jpri/2021/v33i31B31697

Frequency and Clinical Presentation of Colorectal Carcinoma among Patients with Lower Gastrointestinal Symptoms

Shahnawaz Khatti, Riaz Ahmed Memon, Abdul Salam Memon, Fazila Hashmi, Sandesh Kumar, Shahida Khatoon, Faryal Hussain Memon & Ahmed Hussain Pathan · Journal of Pharmaceutical Research International · 2021

Objective: To determine the frequency and presentation of colorectal carcinoma (CRC) among the patients presenting with lower gastrointestinal (GI) symptoms. Study Design: Observational study Place and Duration: Department of Surgery, Liaquat University of Medical and Health Scie...

Open access Research Article 10.9734/jpri/2021/v33i31B31699

Microwave-Assisted Synthesis of Some New Mixed Ligand Ni(II) Complexes Its Characterization and Its Antimicrobial Study

Jitendra M. Pawara & Sunil S. Patil · Journal of Pharmaceutical Research International · 2021

Nickel(II) complexes of the type [Ni(P)(L).2H2O] has been synthesized by using 2-amino-6-methyl pyrimidine-4-ol (HP) and amino acids (HL). Complexes synthesized by conventional as well as microwave methods. Results indicate that complexes synthesized by the microwave method are m...

Open access Research Article 10.9734/jpri/2021/v33i31B31700

Evaluation of the Bleeding Complications in Laparoscopic Cholecystectomy in a Tertiary Care Hospital: A Cross-Sectional Study

Muhammad Kamran Ansari, Inayat Ali Zardari, Shazia Awan, Shahnawaz Laghari, Naeem Karim Bhatti, Maimoona Baloch & Arslan Ahmer · Journal of Pharmaceutical Research International · 2021

Objective: To determine the frequency of various sources of bleeding in laparoscopic cholecystectomy with special preference to gallbladder bed excluding port site. Methods: This cross-sectional study was consisted of 163 patients admitted through the outpatient department from P...

Open access Research Article 10.9734/jpri/2021/v33i31B31705

Semibarbula orientalis (Web.) Wijk. and Marg: A Potential Source of Bioactive and High Value Phytochemicals

Vinod Deora & G. S. Deora · Journal of Pharmaceutical Research International · 2021

Aims: Present study aims to evaluate the presence of bioactive compounds of Semibarbula orientalis (Pottiales: Pottiaceae), a bryophyte whole plant methanolic extract by Gas Chromatography-Mass Spectrometry (GC-MS) which are important medicinally as well flavouring and colouring...

Open access Research Article 10.9734/jpri/2021/v33i31B31688