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All published articles 7450

The Preventive Effects and Mode of Actions of Ulva Fasciata Synthesized Silver Nanoparticles in Doxorubicin-Induced Hepatotoxicity in Wistar Rats

Asmaa M. Mahmoud, Osama M. Ahmed, Ibraheem B. Mohamed, Hanan A. Soliman & Basant M. Mohamed · Journal of Pharmaceutical Research International · 2021

Background: Hepatotoxicity was one of the major side effects associated with doxorubicin treatment in cancer chemotherapy. The synthesized silver nanoparticles (AgNPs) from natural products such as algae especially green algae is one of the favorable means to minimize the deleter...

Open access Research Article 10.9734/jpri/2021/v33i24A31429

Isolation and Identification of Uropathogenic E. coli and its Antimicrobial Susceptibility Pattern with Special Reference to Extended Spectrum Beta-Lactamases (Esbl)

V. Naveen Kumar & Chitralekha Saikumar · Journal of Pharmaceutical Research International · 2021

Urinary tract infections (UTI) are the most common bacterial infection among the humans. One of the most important factors impacting the management of UTI over the past decade is emergence of anti-microbial resistance among uropathogens. ESBL production is one of the most common...

Open access Research Article 10.9734/jpri/2021/v33i24A31431

Study of the Bacteriological Profile and Their Antimicrobial Susceptibility Pattern in Patients with Skin Infections

M. Nandini & S. B. Kiran Madhusudhan · Journal of Pharmaceutical Research International · 2021

The study group consisted of 150 patients both male and female between 1 – 80 years, with primary and secondary skin infections who attended the out- patient department of Dermatology and surgery at Sree Balaji medical college and hospital a tertiary care hospital in Chennai, Tam...

Open access Research Article 10.9734/jpri/2021/v33i24A31433

Azithromycin Pulse Therapy with Oral Doxycycline in the Treatment of Acne Vulgaris, a Randomized Group Study

C. Sadhana & N. S. Muthiah · Journal of Pharmaceutical Research International · 2021

Acne vulgaris is a common dermatological problem. The choice of proper treatment is determined by the severity and extent of acne. Moderate to severe acne vulgaris cases respond well to systemic antibiotics. Antibiotics execute their anti-propionic bacterium effect by inhibiting...

Open access Research Article 10.9734/jpri/2021/v33i23B31411

Impact of Movement with Mobilization and Triceps Eccentric Strengthening in Tennis Elbow: Case Report

Nabeela Fatema, Bodhisattva Dass & Rinkle Hotwani · Journal of Pharmaceutical Research International · 2021

Background: Tennis elbow can be caused by repetitive wrist and arm motions. Pain is the primary symptom. It usually occurs on the outside of the elbow and sometimes in the forearm and wrist. Treatment includes rest, pain relievers and physiotherapy. Case Presentation: A 28years o...

Open access Research Article 10.9734/jpri/2021/v33i23B31412

Detection of Gram Negative Bacilli Producing Extended Spectrum Beta Lactamase on Intensive Care Unit at Tertiary Care Hospital

M. Nishanthy & Chitralekha Saikumar · Journal of Pharmaceutical Research International · 2021

Antimicrobial resistance is a budding threat worldwide. The every class of antibiotic agents must have resistance mechanisms.The principal mechanism for resistance to the β-lactam antibiotics in gram-negative bacteria is the production of β-lactamase. The creation of extended-spe...

Open access Research Article 10.9734/jpri/2021/v33i23B31413

Phytochemical Profiling and Antioxidant Activity of Aqueous Leaf Extract of Vitex negundo

Govindarajan Umamaheswari, Kuppusamy Selvam & Palanisamy Prakash · Journal of Pharmaceutical Research International · 2021

Natural products from plants, animals and minerals are the basis for treating human diseases. The present investigation explains that the antioxidant potential of aqueous extract of vitex negundo leaves.  Phytochemical constituents, total phenolic and flavanoid content of aqueous...

Open access Research Article 10.9734/jpri/2021/v33i23B31418

A Bone Marrow Aspiration Study in Evaluation of Severe Anemia in Adults

T. Ayeesha Sithika, Priavadhana Rajan Prasaad & Vindu Sivastava · Journal of Pharmaceutical Research International · 2021

Anemia is a global health challenge and is the most significant health problem encountered in the developing countries especially in India. According to the World Health Organisation (WHO), 1.62 million !! billion people per year are affected globally with anemia which constitute...

Open access Research Article 10.9734/jpri/2021/v33i23B31419

Curcumin Scavenges Peroxynitrite in RAW 264.7 Macrophages through Phenolic Hydroxyl Groups

Mustafa Kassim, Nazeh M Al-abd, Mohd Shahnaz Hasan, Marzida Mansor & Mohamed Izham Mohamed Ibrahim · Journal of Pharmaceutical Research International · 2021

Background: Overproduction of free radicals is implicated in cell death and tissue injury. Peroxynitrite (PN) is a highly oxidizing and short-lived free radical that is formed by the interaction of nitric oxide (NO) with superoxide. Curcumin is a natural compound obtained from Cu...

Open access Research Article 10.9734/jpri/2021/v33i23A31414

Isolation, Identification, Speciation and Antibiotic Susceptibility Pattern of Klebsiella Species among Various Clinical Samples at Tertiary Care Hospital

K. Sathyavathy & B. Kiran Madhusudhan · Journal of Pharmaceutical Research International · 2021

To isolate, identify and speciate Klebsiella from various clinical samples and their Antimicrobial susceptibility pattern at tertiary care hospital, Chennai. Out of this 76 ESBL producing Klebsiella pneumoniae, 64(84%) were positive by Double Disc Synergy Test (DDST), 71(93%) by...

Open access Research Article 10.9734/jpri/2021/v33i23A31415

Awareness and Utilization Pattern of Over-the-Counter Painkillers amongst Health professional Students in a Medical University

Abir Al-Azi, Aya Dzhakha & Subish Palaian · Journal of Pharmaceutical Research International · 2021

Objective: Pain relievers are one of the most frequently purchased over-the-counter medications and are vulnerable to be misused, leading to safety concerns. This study was conducted to assess the awareness and self-medication practices of over-the-counter analgesics amongst heal...

Open access Research Article 10.9734/jpri/2021/v33i23A31416

Status of Transferrin Saturation in Diabetic Nephropathypatients

R. Dinesh Kumar, A. J. Manjula & B. Shanthi · Journal of Pharmaceutical Research International · 2021

Serum transferrin saturation (TSAT%) ratio is a commonly used laboratory measure of iron deficiency and iron overload in clinical practice. It has  become a  first step in the routine screening of iron deficiency anaemia in  patients with chronic kidney disease  and  for  the  de...

Open access Research Article 10.9734/jpri/2021/v33i23A31417

Evaluating the Effect of Amine-geldanamycin Hybrids on Antiviral Activity against Influenza Virus

Thongchai Taechowisan, Tipparat Samsawat, Chanjira Jaramornburapong, Weerachai Phutdhawong & Waya S. Phutdhawong · Journal of Pharmaceutical Research International · 2021

Aims: The purpose of this study was to synthesis novel amine-geldanamycin hybrids (AGH) and evaluate their biological properties. Study Design: Experimental study. Place and Duration of Study: The study was carried out at the Department of Microbiology and Department of Chemistry...

Open access Research Article 10.9734/jpri/2021/v33i22B31400

A Study of Non Alcoholic Fatty Liver Disease in Metabolic Syndrome Patients

Pinky Karam, V. S. Kalaiselvi & B. Shanthi · Journal of Pharmaceutical Research International · 2021

The study aims to determine the association of nonalcoholic fatty liver disease in metabolic syndrome patients to find out the prevalence of nonalcoholic fatty liver disease in the already diagnosed metabolic syndrome patients selected from the South Indian population. Find out t...

Open access Research Article 10.9734/jpri/2021/v33i22B31401

Antibacterial and Antifungal Activity of Plant Extracts from Spinacia oleraceae L. (Amaranthaceae)

Firza Shafique, Uzma Naureen, Annam Zikrea, Sohail Akhter, Tanzila Rafique, Rumana Sadiq, Mehwish Naseer, Qaiser Akram & Qurban Ali · Journal of Pharmaceutical Research International · 2021

Spinach (Spinacia oleracea L. SO) leaves represent an important dietary source, have high nutritional value and antimicrobial properties. Spinach leaves have been used in the treatment of human diseases since ancient times. Here, the aim of this study was to evaluate the antimicr...

Open access Research Article 10.9734/jpri/2021/v33i22B31410