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All published articles 7450

Pattern of Use Unlicensed Medication in Pediatrics: A Retrospective Study at Major Tertiary Care Hospital in Saudi Arabia

Abdulaziz Alolayan, Basil Almansour, Yasmin Barnawi, Husam Munawar, Saad Almodamegh, Huda Aldossari & Wael Mansy · Journal of Pharmaceutical Research International · 2021

Background: Unlicensed medication use (off label use) is common in pediatrics practice. There are more than 75% of drugs which approved for using in adults, data of efficacy and safety in pediatric population is not completely available, and missed data might be due to some reaso...

Open access Research Article 10.9734/jpri/2021/v33i19A31329

A Prospective Observational Study on Prevalence and Prognostic Indicators among Tuberculosis and Multidrug Resistance Tuberculosis Patients in Tertiary Care Teaching Hospital

A. Noorjahan, B. Bhargavi, K. Mallikarjuna, B. Mohammad Ishaq, L. Siva Sankar Reddy & R. E. Ugandar · Journal of Pharmaceutical Research International · 2021

Tuberculosis (TB) is a communicable systemic infectious disease with high morbidity and mortality associated with it. Resistance to medications used to treat tuberculosis has been on the rise in recent years. (multidrug-resistant tuberculosis)  (MDR-TB)  is a significant challeng...

Open access Research Article 10.9734/jpri/2021/v33i19A31326

Clinical Presentation of Mandibular Impacted Teeth and Associated Pathologies in the Unaizah, Al Qaseem; Saudi Arabia

Khaled Ramzi Shora, Kashif Ali Channar, Irfan Ahmed Shaikh, Abdul Bari Memon, Abdul Hayee Shaikh, Bhavesh Maheshwari, Ram Pershad & Mahnoor Memon · Journal of Pharmaceutical Research International · 2021

Aim: The aim of this study was to evaluate the clinical presentation of mandibular impacted teeth and associated pathologies in Unaizah, Al Qaseem; Saudi Arabia. Study Design: Descriptive cross sectional study. Place and Duration of Study: Department of Oral and Maxillofacial Sur...

Open access Research Article 10.9734/jpri/2021/v33i19A31327

Frequency of Spontaneous Bacterial Peritonitis in Cirrhosis of Liver in Department of Medicine at People Medical College Hospital Nawabshah Pakistan

Jeando Khan Daidano, Amir Shahzad, Safdar Ali Pervez Tunio, Anwar Ali Jamali, Arslan Ahmer & Muhammad Saleem Rind · Journal of Pharmaceutical Research International · 2021

Introduction: Bacterial Infections in cirrhosis of liver is one of the main complications with increase mortality rate. Infection of ascitic fluid in cirrhosis of liver was introduced by Conn and fessel [2], termed as spontaneous bacterial peritonitis. Objective: To determine the...

Open access Research Article 10.9734/jpri/2021/v33i19A31328

Application of Genome Editing Technologies for Disease Treatment: Review

Girum Tefera Belachew, Paramesh Hanumanthaiah & Bitaniya Abera Tekelemariam · Journal of Pharmaceutical Research International · 2021

The improvement of particularly versatile genome-modifying advancements has outfitted experts with the ability to rapidly and monetarily bring sequence-specific changes into the genomes of a wide scope of cell types and organisms. The CRISPR framework was first found as a protect...

Open access Research Article 10.9734/jpri/2021/v33i19A31320

Development and Characterization of Mitoxantrone-Loaded Glutaraldehyde Crosslinked Sodium Alginate Nanoparticles for the Delivery of Anticancer Drugs

Muhammad Wahab Amjad & Maria Abdul Ghafoor Raja · Journal of Pharmaceutical Research International · 2021

Every year millions of new cases of various types of cancers are diagnosed, leading to an alarming rate of fatalities. Mitoxantrone is an anthracenedione antineoplastic agent which is used in the treatment of various types of cancer, mostly acute myeloid leukemia and prostate can...

Open access Research Article 10.9734/jpri/2021/v33i19A31321

Application of Percutaneous Screw Fixation and Closed Reduction for Tibial Plateau Fractures in Karachi, Pakistan

Muhammad Azeem Akhund, Muhammad Latif, Rahat Zahoor Moton, Zohaib Khan, Zohaib Nawaz & Nusrat Rasheed · Journal of Pharmaceutical Research International · 2021

Objective: Objective of this study is to assess the application of percutaneous screw fixation and closed reduction for tibial plateau fractures in Karachi, Pakistan. Methods: The study design of this study is case series with sample size of 58 patients calculated by WHO calculat...

Open access Research Article 10.9734/jpri/2021/v33i19A31322

Evaluation of the Toxicological Profile of Commiphora opobalsamum in Wister Rats for Its Safety and Rational Use

Mai A. Alim A. Sattar Ahmad, Akram A. Al-Salmi, Fatemah O. Kamel & Lateef M. Khan · Journal of Pharmaceutical Research International · 2021

Aim: To study acute and chronic toxicity profile of Commiphora opobalsamum (CO) in rats. Methods: Acute oral lethal effect and single oral dose toxicity of CO was determined in rats by comparison with standard control. In contrast repeated dose oral toxicity in rats were performe...

Open access Research Article 10.9734/jpri/2021/v33i19A31324

The Serological Basis of the Correlation between Iron Deficiency Anemia and Thyroid Disorders in Women: A Community Based Study

Riazul Islam, Kazi Mahmuda Akter, Atikur Rahman, Nurun Nahar Khanam, Salauddin Al Azad, Md. Raihanul Islam, Mithila Farjana, Mohammad Habibur Rahman, Md. Nasir Uddin Badal, Sharmin Ahmed & . Assaduzzaman · Journal of Pharmaceutical Research International · 2021

Objectives: Iron Deficiency Anemia (IDA), a global public health problem may have an inimical effect on thyroid function, especially in women and children. This study was conducted to inspect the correlation between IDA and thyroid disorders in women of Bangladesh. Methods: A cro...

Open access Research Article 10.9734/jpri/2021/v33i19A31330

Risk Factors and Quality of Life of Lung Cancer Survivors in Lahore, Pakistan

Rehan Ahmad Khan Sherwani, Sajjad Ali Gill, Saba Younus, Sana Saeed, Nadia Saeed & Hira Shahid · Journal of Pharmaceutical Research International · 2021

Introduction: The objectives of this study is to determine the risk factors of lung cancer were patients and investigate the quality of life of lung cancer survivors. The occupational, smoking, personal, environmental and family history of the survivors are investigated. The well...

Open access Research Article 10.9734/jpri/2021/v33i1831317

Development of Tinidazole Loaded Polymeric Nanoparticles Formulation and its Characterization

K. Tirumala Devi & B. S. Venkateswarlu · Journal of Pharmaceutical Research International · 2021

Introduction: The development of safe drug delivery systems for a therapeutic agent with less side effects and more bioavailability to the targeted site is very vital in drugs formulation. Tinidazole (TZ) is a drug used to treat giardiasis, amebiasis for colon infections and othe...

Open access Research Article 10.9734/jpri/2021/v33i1831318

Functional Limitations of Hyper and Hypothyroid Patients in INMOL Hospital Lahore, Pakistan

Rehan Ahmad Khan Sherwani, Sajjad Ali Gill, Nadia Saeed, Sana Saeed, Ayesha Habib & Hira Shahid · Journal of Pharmaceutical Research International · 2021

Introduction: Thyroid disease is extremely prevalent than heart diseases or diabetes. Hormones produced by the thyroid gland maintain the muscles, heart, brain, and other organs of the body. Improper performance of the thyroid gland leads to an overactive thyroid (hyperthyroidism...

Open access Research Article 10.9734/jpri/2021/v33i1831319

Method to Develop and Stress Degradation Profile of N-(2,6-dimethylphenyl)-2-{[5-(1H-indol-3-ylmethyl)-1,3,4-oxadiazol-2-yl]sulfanyl}Acetamide Studied by UV Spectroscopy

Muhammad Shaharyar Khan Afridi, Abida Latif, Hafiz Hanzalah Fahham, Kaneez Rubab, Itzaz Aslam & Saiqa Ishtiaq · Journal of Pharmaceutical Research International · 2021

Background: Synthetic chemistry has always served as a back bone to the medicinal and pharmaceutical chemistry in terms of drug development and drug optimization. It helped in a great deal in finding new lead compounds and synthesizing new drugs. A new molecule N-(2,6-Dimethylphe...

Open access Research Article 10.9734/jpri/2021/v33i1831325