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All published articles 7450

Evaluation of the Antihyperlipidemic and Antioxidant Effects of Catharanthus roseus Extracted from Vinca minor in Diabetic Rats

Shimaa Mohammed Hasnin Aboelnaga · Journal of Pharmaceutical Research International · 2021

The role of oxidative stress is known among the patients of diabetes as the level of reactive oxygen species was high among diabetic patients. This oxidative stress is generated in diabetic patients due to continuous high glucose levels that cause to decrease in the defence mecha...

Open access Research Article 10.9734/jpri/2021/v33i231142

Anti- Parkinsonian Drug Estimation by RP-HPLC

Rama Rao Nadendla & Patchala Abhinandana · Journal of Pharmaceutical Research International · 2021

Aim: The main aim of the current study is to give best and simple method for the estimation of antiparkinsonian drugs named Carbidopa, levodopa and entacapone. Study Design:  Simultaneous estimation of Carbidopa, levodopa and entacapone was performed by using Quadrapumped (SHIMAD...

Open access Research Article 10.9734/jpri/2021/v33i231143

Renoprotective Effect of Formononetin against Cyclophosphamide-Induced Oxidative Stress and Inflammation in Rat Kidney

Saleem H. Aladaileh, Farhan K. Al-Swailmi, Mohammad H. Abukhalil & Mohammed H. Shalayel · Journal of Pharmaceutical Research International · 2021

Aims: Cyclophosphamide (CP) is a broad-spectrum chemotherapy agent available to treat various malignancies; however, its nephrotoxicity limits its clinical use. Formononetin (FOR) is a bioactive isoflavone with encouraging biological activities. The current study explored and elu...

Open access Research Article 10.9734/jpri/2021/v33i231144

Evaluation of Haematological Alterations in Children Infected by Plasmodium falciparum Species in Enugu, Enugu State, Nigeria

Linda Nnenna Ogbonna, Silas Anayo Ufelle, Emmanuel Ifeanyi Obeagu & Cyril Okonkwo Ogbonna · Journal of Pharmaceutical Research International · 2021

Malaria accounts for a considerable amount of Morbidity and mortality with children bearing the greatest burden. The study aimed to investigate the haematological alterations in children infected by Plasmodium falciparum (P. falciparum) species. A case control study with a total...

Open access Research Article 10.9734/jpri/2021/v33i231145

Race as Determinant of Red Blood Cell Osmotic Stress Haemolysis in South Indian and African Populations

Hassan Thabit Haji, Chukwuma J. Okafor, Emmanuel Ifeanyi Obeagu, Othman Hakum Said, Kirtana R. Nayak, Nkem F. Obianagha & Emilio Stivens Galano · Journal of Pharmaceutical Research International · 2021

The study was to compare the red blood cell osmotic fragility between South Indian and African ethnicities. A cross sectional study was performed in the Department of Physiology, Kasturba Medical College, Manipal. The study involved apparently healthy young adults between 18 to 4...

Open access Research Article 10.9734/jpri/2021/v33i231146

Frequency of Carbonated Beverage Drinking, Knowledge Regarding its Risks on Health and Association with Bone Mineral Density in Medical Students

Syed Sohail Abbas, Bushra Begum Ramejo, Asadullah Mehar, Khush Muhammad Sohu, Syeda Abiya Amber Naqvi & Sobia Aftab · Journal of Pharmaceutical Research International · 2021

Background: The carbonated drink manufacturing companies has set young school/college going children as their primary target customers who are consuming it on daily basis and frequency of drinking vary depending on affordability and need. The consumption of carbonated drink has b...

Open access Research Article 10.9734/jpri/2021/v33i131136

Wrist Arthrodesis in Severe Wrist Arthritis in Rheumatoid Arthritis Patients: A Retrospective Study

Amit Lakhani, Ena Sharma & Harsh Mander · Journal of Pharmaceutical Research International · 2021

Objective: Osteoarthritis of wrist is an uncommon disorder but in rheumatoid arthritis (RA), wrist and metacarpophlangeal joint are involved in early stages. RA of wrist leads to severe pain and loss of function in a large number of patients. Conservative treatment is required in...

Open access Research Article 10.9734/jpri/2021/v33i131138

Antimicrobial Activity of Pregnenolone in vitro

Teodora P. Popova, Ignat Ignatov, Toshka Petrova & Georgi Dinkov · Journal of Pharmaceutical Research International · 2021

The antimicrobial effect of pregnenolone on clinical and reference strains of Escherichia coli and Staphylococcus aureus was tested. Pregnenolone was found to have inhibitory activity against all tested bacterial strains. Slightly higher sensitivity is shown by the strains of S....

Open access Research Article 10.9734/jpri/2021/v33i131139

In-vivo Hypoglycemic Activity of Grewia asiatica Fruit Extract in Streptozotocin Mediated Diabetic Rats

Zuneera Akram, Aisha Noreen, Muzammil Hussain, Maryam Inayat, Sobia Akhter, Usman Ghani Farooqi, Anum Akram & Waqar Ahmed Sabzoi · Journal of Pharmaceutical Research International · 2021

Diabetes mellitus has high global prevalence and occurrence and is considered to bean endocrinological and/or metabolic disorder. Conventional drug treatment is costly and has toxic side effects, although it is successful in treating diabetes mellitus. If effective and less toxic...

Open access Research Article 10.9734/jpri/2021/v33i131140

Bioanalytical Method Development and Validation for the Simultaneous Determination of Vildagliptin and Telmisartan in Rabbit Plasma Using RP-HPLC

Budideti Kishore Kumar Reddy, Kothapalli Bonnoth Chandra Sekhar & Chinnala Krishna Mohan · Journal of Pharmaceutical Research International · 2021

A simple, reproducible bioanalytical method of liquid chromatography and PDA detector was developed and validated for the simultaneous Determination of Vildagliptin and Telmisartan in Rabbit Plasma using liquid-liquid extraction technique. K2 EDTA was used as anti-coagulant. Anal...

Open access Research Article 10.9734/jpri/2021/v33i131141

Exploring Effect of Perturbing Forces on Periodic Orbits in the Restricted Problem of Three Oblate Spheroids with Cluster of Material Points

Oni Leke & Jagadish Singh · Journal of Pharmaceutical Research International · 2021

This paper explores effect of perturbing forces on periodic orbits generated by the triangular equilibrium points of the restricted three-body problem taking into account small perturbations in the Coriolis and centrifugal forces when the infinitesimal mass is an oblate spheroid...

Open access Research Article

“Caffeine and Its Impact with Physical and Status of Mental Health among University Students in the United Kingdom”

Shimaa Mohammed Hasnin Aboelnaga · Journal of Pharmaceutical Research International · 2021

This research study aims to analyze the impact of caffeine on the physical and mental health of university students within the United Kingdom. The research has made use of a mixed-methods methodology, involving both the qualitative and quantitative analysis methods, to collect an...

Open access Research Article 10.9734/jpri/2021/v33i131135

Assessment of Lipid Profile and Serum Creatinine Kinase in Subjects with Hyperlipidemia on Moderate Intensity Statin Therapy Attending a Postgraduate Teaching Hospital in South India

T. K. Mohammed Muneersha, R. T. Saravanakumar & K. G. Revikumar · Journal of Pharmaceutical Research International · 2021

Atherosclerosis of large and medium sized arteries are believed to be the major reason behind the development of Coronary Artery Diseases and Hyperlipidemia has been found to be one of the most important contributing factors. Appropriate lifestyle changes along with proper drug t...

Open access Research Article 10.9734/jpri/2021/v33i131132

Females Awareness and Attitudes Regarding Breast Self-Examination and Breast Cancer in Riyadh Province

Nehad J. Ahmed, Saad M. Alshahrani, Alanoud Almutiran, Abdulrahman S. Alrawili & Faisal Z. Alkhawaja · Journal of Pharmaceutical Research International · 2021

Aim: This study aimed to evaluate the awareness and attitudes of females in Riyadh province regarding breast cancer and breast self-examination. Methodology: This is a retrospective study that was conducted using a survey that was adapted from previously published studies that we...

Open access Research Article 10.9734/jpri/2021/v33i131133