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All published articles 7450

Bovine Theileriosis: Epidemiology, Pathogenesis, Diagnosis, and Control Strategies

Taghreed H. Alwuthaynani, Haleema Y. Alnahari, Muslimah N. Alsulam, Fatimah H. Khouja, Amnah H. Khouja, Hanan M. AlJamei, Haneen N. Ahmed & Haleema H. Albohiri · Journal of Pharmaceutical Research International · 2026

Bovine theileriosis is a significant tick-borne parasitic disease that poses a major threat to cattle health and productivity. This review summarizes current understanding of its etiology, epidemiology, pathogenesis, clinical manifestations, diagnostic approaches, and control wit...

Open access Research Article 10.9734/jpri/2026/v38i57838

Computer-Aided Design of Imidazo [4.5-c] Pyridin-4-one Derivatives as Antagonists of the Angiotensin II Type 1 (AT1) Receptor

Abel Landry Tebily, Akoun Abou, Issouf Soro, Abdoulaye Djandé, Niaré Adama & Megnassan Eugène · Journal of Pharmaceutical Research International · 2026

Over the past decade, drug resistance has emerged as a major challenge in the treatment of high blood pressure. This report evaluates new imidazo[4.5-c]pyridin-4-one compounds designed to inhibit the AT1 enzyme, and highlights their therapeutic potential, supported by favourable...

Open access Research Article 10.9734/jpri/2026/v38i57837

Rare Plant-Derived Polysaccharides as Next-Generation Drug Delivery Carriers: Opportunities, Challenges, and Future Perspectives

Antesh Kumar Jha, Shiv Kumar Srivastava, Mahesh Prasad, Shashi Shankar, Abhishek Kumar Singh & Anant Prakash Pandey · Journal of Pharmaceutical Research International · 2026

Rare plant-derived polysaccharides have emerged as promising biomaterials for advanced drug delivery due to their structural adaptability and functional performance. This review critically evaluates polysaccharides from underutilized sources such as tamarind seed, fenugreek, bael...

Open access Research Article 10.9734/jpri/2026/v38i57835

A Comprehensive Review of the Pharmacological, Toxicological and Phytochemical Properties of Parkia biglobosa

Mahamadou Maiga, Geoffroy Gueswindé Ouedraogo, Sylvain Ilboudo, Gaétan Donzéo Somda, Noufou Ouedraogo, Salfo Ouédraogo, Jules Yoda, Rasmané Semdé & Sylvain Ouedraogo · Journal of Pharmaceutical Research International · 2026

Parkia biglobosa is a plant widely used in traditional African medicine. It has been the subject of several studies aimed at gaining a better understanding of the species, formalizing its medicinal uses, and developing its potential. The aim of this review is to provide an up-to-...

Open access Research Article 10.9734/jpri/2026/v38i47834

Knowledge, Attitude and Practice Regarding Antibiotic Use and Self- Medication in MBBS Students: A Cross-Sectional Study

Panchal Ripal Nandlal & Galachar Hiral Lakhabhai · Journal of Pharmaceutical Research International · 2026

Background: Antibiotic misuse and self-medication contribute significantly to antimicrobial resistance (AMR), a major global health threat. Medical students, despite their education, often engage in self- medication with antibiotics, highlighting a concerning gap between knowledg...

Open access Research Article 10.9734/jpri/2026/v38i47833

Implementation and Qualification of a Dual Activated Carbon Filtration System for Persistent GMP-Compliant Water Purification

Alberto Leyva, Joel Ríos, Sonny Robles, Anabel Duarte, Osmaro González, Dalgys E. Rodríguez, Lisbet Melo, Ilena García, Manuel Montané & Tania de la Cruz · Journal of Pharmaceutical Research International · 2026

Activated carbon filters are essential in pharmaceutical water systems, ensuring removal of chlorine, organic matter, and microbial contaminants. Modernization of legacy systems is critical to maintain compliance with pharmacopeial and GMP requirements. This study describes the u...

Open access Research Article 10.9734/jpri/2026/v38i47832

Pediatric Nephrotic Syndrome with Patent Ductus Arteriosus and Mild Ascites: A Rare Case Report

Rahul Shil & Saikat Das · Journal of Pharmaceutical Research International · 2026

Nephrotic syndrome, a prevalent pediatric renal disorder, manifests with significant proteinuria, hypoalbuminemia, oedema, and hyperlipidemia. Complications associated with nephrotic syndrome include infections, ascites, and pleural effusion. Congenital cardiac anomalies, such as...

Open access Research Article 10.9734/jpri/2026/v38i47831

Experimental Advances in Drug Solubility and AI-Driven Strategies for Drug Solubility Enhancement: Current Trends and Future Prospects

Ugodi Walter Gerald & Ikpechukwu Martins Detu · Journal of Pharmaceutical Research International · 2026

The aqueous solubility of a drug is a fundamental determinant of its therapeutic efficacy, directly influencing dissolution rates, absorption, and systemic bioavailability. Currently, a significant portion of new drug candidates face challenges related to poor aqueous solubility,...

Open access Research Article 10.9734/jpri/2026/v38i47830

Knowledge, Attitude, and Practice of Community Pharmacists in Sudan: A Comprehensive Review of Clinical Competence and Pharmaceutical Care

Bashir A. Yousef & Kannan O. Ahmed · Journal of Pharmaceutical Research International · 2026

The position of the community pharmacists (CPs) in the control and management of communicable and non-communicable conditions is central. However, this largely depends on the knowledge, attitude, and practice (KAP) of the CPs. The purpose of this comprehensive review was to asses...

Open access Research Article 10.9734/jpri/2026/v38i47829

Successful Non-operative Management of Spontaneous Splenic Rupture with Hemoperitoneum in Plasmodium vivax Malaria: A Case Report from Central India

Sagar Gupta, Mohak Jain, Rohan Bhutra, Utsav Panjabi, Shanket Harsh & Hari Om Soni · Journal of Pharmaceutical Research International · 2026

Background: Plasmodium vivax malaria, traditionally considered benign, is now increasingly recognized as a cause of severe and life-threatening complications. Among these, spontaneous splenic rupture (SSR) is a rare but critical emergency associated with significant morbidity and...

Open access Research Article 10.9734/jpri/2026/v38i47828

In vitro Evaluation of Thrombolytic Activity and Flavonoid Profiling of Borassus flabellifer L. Using Streptokinase as Standard on Chicken Blood Clots

N. Satheeshkumar, V.S. Bharathraj, A. Deenadhayalan, R. Deepika, P. Dhanush Kumar, S. Kannan & B. Sangameswaran · Journal of Pharmaceutical Research International · 2026

Background: Thrombotic disorders, characterized by fibrin-rich clot formation within blood vessels, are a leading cause of global morbidity and mortality worldwide (World Health Organization, 2023). Thrombolytic agents such as streptokinase act by converting plasminogen into plas...

Open access Research Article 10.9734/jpri/2026/v38i47827

Cost-Effectiveness of Routine Outpatient Follow-Up Intervals in Adults with Sickle Cell Anemia: A Pilot Study from Cameroon

Ngoe Samuel Bakia, Chetcha Bernard Chenmagni, Eustace Bonghan Berinyuy, Estella Achick Tembe-Fokunang, Mbappe Herguel Epoh & Charles Fokunang · Journal of Pharmaceutical Research International · 2026

Background: Sickle cell disease (SCD) requires lifelong management and monitoring, yet in Cameroon, many adults seek care only during crisis, driving hospitalizations and healthcare costs. This study examined whether adults with sickle cell anemia (SCA) attending ≥3 routine follo...

Open access Research Article 10.9734/jpri/2026/v38i37824

Bridging Knowledge Gaps in Herpes Zoster Prevention and Vaccine Acceptance through a Knowledge Attitude Practice Study for Sustainable Health

Saranya Punniyakotti, D. Sakthi Sanjana, D. Yuvarani, S. R. Mayuricca, B. Chaithanya, Nithya Varadarajan & Sambasivam Gopinath · Journal of Pharmaceutical Research International · 2026

Background: Shingles (Herpes Zoster) is a painful viral disease caused by reactivation of the Varicella-zoster virus, primarily affecting individuals with a history of chickenpox. Despite the availability of effective vaccines, awareness and preventive practices remain inadequate...

Open access Research Article 10.9734/jpri/2026/v38i37825

Geriatric Medication Safety in India: A Review of Potentially Inappropriate Medications Using the Beers Criteria

V. M. Fathima Sana, Lal Prasanth M L, C. R. Shibu Prasanth, T. S. Anju & Dhanya Dharman · Journal of Pharmaceutical Research International · 2026

Background: The geriatric population, defined as individuals aged 65 years and above, is rapidly increasing and presents unique healthcare challenges. It is categorized into young-old (65–74 years), middle-old (75–84 years), and old-old (≥85 years) based on functional and physiol...

Open access Research Article 10.9734/jpri/2026/v38i37826

Bioanalytical Method Validation of LC–MS/MS Assays for Trazodone: A Critical Review Based on USFDA and ICH M10 Guidelines

Vaishnavi Dhangude, Shrikrishna Baokar, Rajendra Patil & Mansingh Rajput · Journal of Pharmaceutical Research International · 2026

Trazodone (TZD) is widely used for the treatment of major depressive disorder, anxiety-related disorders, and insomnia. Accurate quantification of TZD in biological matrices is essential for pharmacokinetic, bioavailability, and bioequivalence studies. Liquid chromatography coupl...

Open access Research Article 10.9734/jpri/2026/v38i37823