In this work, molecular modeling and docking studies of antimicrobial heterocyclic compounds were carried out using Auto Dock. Docking studies were carried out for Benzodiazole derivatives to study their affinity to Cell wall anchored (CWA) protein of Staphylococcus aureus. The d...
Open access
Research Article10.9734/jpri/2020/v32i2930890
Meconium stained amniotic fluid (MSAF) is a commonly studied topic in neonatal outcomes. Meconium was commonly thought a precursor to eventual or active fetal death, although, some scholars do not consider this to be connected with foetal hypoxia, fetal acidosis, or trauma. Purpo...
Open access
Research Article10.9734/jpri/2020/v32i2930891
Introduction: Studies have shown the association between subclinical hypothyroidism and type 2 diabetes. However, the common complications of type 2 diabetes, such as diabetic nephropathy and albuminuria with subclinical hypothyroidism, are not fully clear yet. This study thus ai...
Open access
Research Article10.9734/jpri/2020/v32i2930885
Aim: The study aimed to analyze the effect of Sitagliptin with Glimepiride during the treatment to improve pancreatic beta-cells in T2DM patients. Beta cells are type of cell found in pancreatic islet and also synthesize, secrete the insulin and amylin. Sitagliptin is found to be...
Open access
Research Article10.9734/jpri/2020/v32i2930887
The cancer is the world's most silent and life-threatening diseases, which may arise in most common people without any indication at any age and result in uncontrolled growth and metastasis. In the current manuscript, we targeted the discovery of novel carbonic anhydrase IX inhib...
Open access
Research Article10.9734/jpri/2020/v32i2930886
Background: Our previous study of the lipid peroxidation and antioxidant defense system (LPO-AOS) state in women with chronic viral hepatitis (CVH) showed the content of fat-soluble vitamin alpha tocopherol significant reduction. Reproductive health of women with CVH needs specia...
Open access
Research Article10.9734/jpri/2020/v32i2930884
Background and Objective: Polo like kinase-1 (PLK-1) enzyme belongs to serine/threonine protein kinase family that is regarded as a principle mitotic controller of G2-M phase transition. The antimitotic therapies are a cornerstone for the treatment of metastatic as well as benign...
Open access
Research Article10.9734/jpri/2020/v32i2930880
Ali Bahari, Mohammad Hashemi, Gholam Reza Bahari, Tahereh Fakharian, Sina Gerayli, Abbas Esmail Zadeh, Hamid Reza Sima, Hooman Mosannan Mozaffari, Ali Reza Bakhshipour & Zohreh Bari·Journal of Pharmaceutical Research International·2020
Background: Selecting patients for new direct acting antiviral treatment of HCV has prompted a conflicting matter worldwide because of its high cost and limited availability. Genotyping of IL28B polymorphisms will aid clinical decision making for identifying priorities of urgent...
Open access
Research Article10.9734/jpri/2020/v32i2930881
Objective: To assess the early risk factors and outcomes of the patients presented with acute renal issues, at tertiary care Hospital. Methodology: This descriptive study was conducted at gynaecology and obstetrics department of Liaquat University of medical and health Sciences....
Open access
Research Article10.9734/jpri/2020/v32i2930882
Aims: Biotic stress given by Aspergillus niger enhances trans-resveratrol production in Arachis hypogaea plant. This plant extract increases sir2 gene expression and Replicative Life Span in Saccharomyces cerevisiae. Design of Study: Peanut plant was grown in aseptic environmen...
Open access
Research Article10.9734/jpri/2020/v32i2930883
Famciclovir loaded Solid Lipid Nanoparticles (SLNs) using triglycerides as solid lipids were successfully prepared using the double emulsion-solvent evaporation technique. Formulation parameters like amount and type of lipid and level of surfactants affected the nanoparticle char...
Open access
Research Article10.9734/jpri/2020/v32i2930879
Stella Chinenye Kama, Emmanuel Ifeanyi Obeagu, M. N. Alo, Kingsley Chinedum Ochei, Uchenna Modestus Ezugwu, Michael Odo, Mabel Ikpeme, Chukwulete Okafor Ukeekwe & Augustine Amaeze Amaeze·Journal of Pharmaceutical Research International·2020
The investigation of urinary tract infection (UTI) among diabetic patients 15-51 years and above was assessed using 100 mid-stream urine specimen with the objective of isolating and identifying different types of bacteria and their respective frequencies among diabetic patients a...
Open access
Research Article10.9734/jpri/2020/v32i2830878
Praveen Kumar Vemuri, Shaik Mohammad Anjum, Lakshmi Saranya Medida, P. V. Hemanth Sai, Mahathi Gummavajjala, Braja Kishori Panigrahi, Swati Dash & Swati Senapati·Journal of Pharmaceutical Research International·2020
Objective: The purpose of the study delineates the growth and plasmid stability of E. coli JM109 host system. Methods: Different concentrations of drugs, chemicals and various frequency of radiations were subjected to the host system to verify the colony forming units along with...
Open access
Research Article10.9734/jpri/2020/v32i2830876
Objective: The objective of the study was to determine the perception of future healthcare providers regarding Amyotrophic Lateral Sclerosis (ALS) in a private medical university. Methods: A cross-sectional study was conducted using a convenience sampling method. A self-developed...
Open access
Research Article10.9734/jpri/2020/v32i2830877
Background and Aim: Cisplatin "cis diamminedichloroplatinum [II] (CDDP) is the most widely used drug in cancer chemotherapy and hepatotoxicity is one of its major side effects. Vorinostat (VST) has been recognized to have an antioxidant and anti-inflammatory effect in low doses....
Open access
Research Article10.9734/jpri/2020/v32i2830872