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All published articles 7450

Segments Associated with the Discernment of Risk and Information of Contracting the 2019-nCoV in India

L. Vijayakumar & J. Sharmila · Journal of Pharmaceutical Research International · 2020

This examination explored hazard discernment and mindfulness among India grown-up members about Coronavirus Disease 2019 (COVID-19). Two self-managed online studies were led on 1000 respondents (320 and 680 members, individually) during the lockdown time frame in India at two sep...

Open access Research Article 10.9734/jpri/2020/v32i2530827

Neonatal Bacterial Sepsis and Its Susceptibility Pattern in Neonatal Care Unit of Tertiary Care Hospital

Abdul Hameed Tunio, Delijan Mugheri, Muhammad Khan, Wasim Sarwar Bhatti, Abdul Majeed Soomro, Pir Bux Ghumro, Sultan Othman Alolayan, Waseem Abbas Malhani, Nadeem Baloch, Altaf Ali Mangi, Zehra Ahraf, Saika Lashari, Kanwal Baloch & Shumaila Parveen Arain · Journal of Pharmaceutical Research International · 2020

Background: The drug resistance and pathogens are different in various Hospitals of any country. Very high resistance pattern is observed nowadays to the frequently used antibiotics. The important observation has been noted that most of the doctors do not obtain blood cultures be...

Open access Research Article 10.9734/jpri/2020/v32i2530828

Selected Plant Extracts Attenuates Dimethylamine and Sodium Nitrite Induced Liver Injury in Experimental Mice

Adewale Adetutu, Olusoji Abiodun Owoade, Ifewumi Racheal Aderibigbe, Olubunmi Simeon Oyekunle, Peter Ifeoluwa Adegbola, Biodun Bukunmi Aborisade, Temitope Deborah OLANIYI & Fatima Aluko Abubakar · Journal of Pharmaceutical Research International · 2020

Dimethylamine (DMA) and sodium nitrite (NaNO2) are present in numerous foods, food additive and environmental factors, which enhance chemical driven liver damage by inducing oxidative stress and cellular injury. Therefore, this study evaluated the possible therapeutic and protect...

Open access Research Article 10.9734/jpri/2020/v32i2530825

Gravity of Poisoning Cases in Shaheed Benazirabad Sindh, Pakistan: A Prospective Study

Shaib Muhammad, Narendar Kumar, Yasmeen Qureshi, Geeta Kumari, Jabbar Abbas, Razia Sultana, Muhammad Saleh Khaskheli, Arslan Ahmer, Jameela Jamali & Rafia Tabassum · Journal of Pharmaceutical Research International · 2020

Aim: It is estimated that more than half a million of people die worldwide due to various incidences of intentional and unintentional poisoning and of them 84% occur in low- and middle-income countries. The clinical presentation of poisoning cases differs by age group, reason of...

Open access Research Article 10.9734/jpri/2020/v32i2530826

Cytokine Storm, Corticosteroids and İnterleukin-6 Receptor Antibodies in Context of Antiinflammatory Treatment in COVID-19

Ozgur Karcioglu, Goksu Afacan, Bilgen Ozkaya, Ebru Yilmaz, Eylem Ersan, Selman Yeniocak & Mandana Hosseinzadeh · Journal of Pharmaceutical Research International · 2020

It is well established that cytokine storm is associated with more severe clinical course of COVID-19. Many clinical findings of COVID-19 and other severe viral infections (e.g. fever, muscle pain, respiratory distress, cough), are directly attributed to cytokine storm. For examp...

Open access Research Article 10.9734/jpri/2020/v32i2530824

18β-glycyrrhetinic Acid Induces Cell Cycle Arrest and Apoptosis in HPV18+ HeLa Cervical Cancer Cells

Mohd Saeed · Journal of Pharmaceutical Research International · 2020

Aims: In recent years, natural products have received great attention to cancer prevention owing to their various health benefits, lack of toxicity, and side effects. Accumulating evidence shows that 18β-glycyrrhetinic acid (GRA) has antiproliferative and apoptotic activities on...

Open access Research Article 10.9734/jpri/2020/v32i2530823

Association of dupA, iceA, homB Genes of Helicobacter pylori with Gastritis, Peptic Ulcer Disease and Gastric Cancer

Muhammad Akram Bajwa, Muhammad Idrees & Prem Kumar Maheshwari · Journal of Pharmaceutical Research International · 2020

Objective: To determine the association of dupA, iceA, homB genes of Helicobacter pylori with gastro-duodenal diseases such as gastritis, peptic ulcer disease PUD and gastric cancer. Materials and Methods: This cross-sectional analytical study was conducted at Gastroenterology De...

Open access Research Article 10.9734/jpri/2020/v32i2530818

Effect of Grape Seed Extract in Minimizing the Harmful Effects of Monosodium Glutamate on the Chicken Embryonic Retina to Show Scientific Miracles In the Holy Quran

Fawzya Al- Gamdi & Nouf Al- Harbi · Journal of Pharmaceutical Research International · 2020

In 1969, a Canadian laboratory announced that its studies on synthetic alkaline (cyclamate) proved to be a carcinogen despite its use for more than twenty years in the beverage industry. There are many additives that have raised the controversy about the large extent of safety to...

Open access Research Article 10.9734/jpri/2020/v32i2530819

Future Perspectives of Biomimetics in Restorative Dentistry

Nazwin Basheer, Manavalan Madhana Madhubala & Sekar Mahalaxmi · Journal of Pharmaceutical Research International · 2020

The main goal of tooth restoration aims at achieving mineralization of initial enamel and dentinal lesions in native form.  Most of the restorative materials and remineralization adjuvants for enamel and dentin mineralization are evidenced in the literature. Although commercially...

Open access Research Article 10.9734/jpri/2020/v32i2530820

Olive Oil Based Organogels for Effective Topical Delivery of Fluconazole: In-vitro Antifungal Study

Mohammad Muqtader Ahmed, Farhat Fatima & Abdul Bari Mohammed · Journal of Pharmaceutical Research International · 2020

The objective of the study was to formulate olive oil based organogels for the topical application of fluconazole (FLZ), to ensure the efficient delivery of the drug deeper in to the skin layers. Methods: Nine formulations developed by hot-melt method using olive oil, sorbitan mo...

Open access Research Article 10.9734/jpri/2020/v32i2530821

An Exploratory Study of Consumers’ Social Behavior towards Role of Malaysian Community Pharmacists in Providing Healthcare

Alamin Hassan Mohamed Alamin Alabid, Mohamed Izham Mohamed Ibrahim, Mohamed Azmi Hassali & Subish Palaian · Journal of Pharmaceutical Research International · 2020

Aims: Consumers’ awareness, perceptions, expectations and experiences are integral components of their satisfaction towards the quality of care provided by community pharmacists. This study aims to assess consumers’ awareness, perceptions, expectations and experiences about the r...

Open access Research Article 10.9734/jpri/2020/v32i2530822

Molecular Mechanism and Role of Translational Values of Heat Shock Protein (HSP27) in Various Disease

Sameer Chaudhary, Sapana Sameer Chaudhary, Sakshi Rawat, Savneet Kaur, Bogireddy Devi, Malik M. Ahmad, Zia Arshad, M. Mustafa, Manie M. Al Jedaie & Pravej Alam · Journal of Pharmaceutical Research International · 2020

HSP27, also known as HSPB1, was first discovered with a molecular weight 27kDa belonging to the four member gene family. Elevated levels of HSP27 are seen when different unfavorable conditions prevail such as increase in temperature and oxidative stress or exposure to heavy metal...

Open access Research Article 10.9734/jpri/2020/v32i2430816

AChE Inhibition Study for Alzheimer's Disease Treatment: An In-silico Study

Mohd Adnan Kausar · Journal of Pharmaceutical Research International · 2020

Alzheimer's disease (AD) is the most common form of dementia associated with plaques and tangles in the brain. Several acetylcholinesterase inhibitors have been clinically used to delay or halt the progression of the disease. Solanadine (Snd) and gamma solamargine (Gsm) have been...

Open access Research Article 10.9734/jpri/2020/v32i2430817

Breast Self Examination: Knowledge and Practice of Young Female Students towards Breast Self Examination and Breast Cancer

Muhammad Parial Shahani, Arslan Ahmer, Fahad Jibran Siyal, Shahid Hussain Soomro, Arsalan Humayun, Abdul Aziz Shaikh, Jabbar Abbas, Zainab Shahani, Raheela Saleem & Ayaz Ali Unar · Journal of Pharmaceutical Research International · 2020

Objective of the study is to assess the knowledge towards breast self-examination (BSE) of breasts among young adults in various districts of Sindh province in Pakistan. Descriptive cross sectional study design was used to conduct the study at Larkana. A total of 171 young female...

Open access Research Article 10.9734/jpri/2020/v32i2430814

In-vitro Evaluation of Antiviral Activity of Moringa oleifera Extracts against Polio virus

Halidu Mhya Adamu, Mahmud Yerima Iliyasu, Mohammed Nuru Yakubu, Adamu Babayo Samaila & Ahmed Faruk Umar · Journal of Pharmaceutical Research International · 2020

Background: Moringa oleifera plant parts extract have been utilized tremendously in traditional medicine, having various pharmaceutical activities such as antifungal, antibacterial and antiviral properties. Aim: This study was carried out to evaluate antiviral activity of aqueous...

Open access Research Article 10.9734/jpri/2020/v32i2430815