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Investigating the Work Environment Conditions and Its Effect on the Moral Sensitivity of Nurses Working in Health-Education Centers of Rasht

Samaneh Usef Shoeibi, Fariba Asgari Bezayeh, Mitra Sedghi Sabet, Atefeh Ghanbari Khanghah & Ehsan Kazemnezhad Leyli · Journal of Pharmaceutical Research International · 2019

Introduction: The scope of nursing care is abundant in cases requiring moral decisions, and awareness of the underlying reasons for choosing a decision is an inseparable part of the daily work of nurses. On the other hand, work environment is also an important part of the organiz...

Open access Research Article 10.9734/jpri/2019/v28i130193

Survey of Subjective Skills of Physical Examination of Children by Nurses and Related Factors in Children's Therapeutic Education Center in Rasht, Iran

Seyedeh Soghra Mirhoseini, Yasaman Yaghoubi, Mahshid Mirzaei & Ehsan Kazamnajad Lili · Journal of Pharmaceutical Research International · 2019

Background and Aim: Since mental skills of nurses are effective on the quality of their activities, this research was conducted with the aim of determining the mental skills of physical examinations of children by nurses and related agents at the Children's Medical Education Cent...

Open access Research Article 10.9734/jpri/2019/v28i130194

New Methionine-based P-toluenesulphonamoyl Carboxamide Derivatives as Antimicrobial and Antioxidant Agents: Design, Synthesis and Molecular Docking

Melford Chuka Egbujor & Uchechukwu Chris Okoro · Journal of Pharmaceutical Research International · 2019

Aim: The reported emergence of drug resistant microbes and the prevalence of oxidative stress related diseases prompted the need for the development of new antimicrobial and antioxidant agents. The synthesis of methione-based sulphonamoyl carboxamides bearing aniline, pyridine an...

Open access Research Article 10.9734/jpri/2019/v28i130192

Efficacy of the Peganum Harmala Oil Versus 1% Permethrin Shampoo on the Treatment of Head Louse Infestation

Mina Maarefvand, Hoorieh Mohammadi Kenari, Ali Ghobadi, Alireza Soleimani & Fataneh Hashem-Dabaghian Hashem-Dabaghian · Journal of Pharmaceutical Research International · 2019

Introduction: Head louse infestation is one of the major public health problems among children worldwide. Several drugs have been developed to treat the infestation. Side effects and drug resistance associated with these drugs limit their applicability. Increasing attention of sc...

Open access Research Article 10.9734/jpri/2019/v27i630190

An Overview of Different Synthetic Routes for the Synthesis of Phthalazine Derivatives

Smita Singh & Nitin Kumar · Journal of Pharmaceutical Research International · 2019

This review paper describes the different synthetic routes used for the synthesis of substituted phthalazine derivatives. Phthalazines have been used as building blocks for the synthesis of a new molecule with heterocyclic structure. These new molecules are highly useful in medic...

Open access Research Article 10.9734/jpri/2019/v27i630189

Enhancement of Doxorubicin Cytotoxicity by Verapamil in Human Breast Cancer Cells

Sameer E. Al-harthy, Mashael S. Al-Motairi, Huda M. Al-Kreathy, Fatemah O. Kamel, Mohamed M. Sayed-Ahmed, Etimad Abbas Huwait, Hamdan S. Al-Malkey & Abdel-Moneim M. Osman · Journal of Pharmaceutical Research International · 2019

Background: Worldwide, breast cancer is a main cause of morbidity and mortality in females. Doxorubicin (DOX) is an anthracycline anticancer drug and most commonly employed in polychemotherapy protocols in the treatment of solid and hematological tumors. Unfortunately, its optima...

Open access Research Article 10.9734/jpri/2019/v27i630188

Effects of Thioxanthene Containing Anti-Psychotic and Anti-Platelet Drug Combination on Mean Platelet Volume and Platelet Distribution Width in Rats

Muhammad Irfan Bashir, Uzma Saleem, Fareeha Anwer & Bashir Ahmad · Journal of Pharmaceutical Research International · 2019

Aim: To evaluate the combined and individual effects of thioxanthene containing antipsychotic and anti-platlet drug on Mean Platelet Volume (MPV) and Platelet Distribution Width (PDW) in rats. Methods: This investigational study comprised of 100 albino rats of both sexual orienta...

Open access Research Article 10.9734/jpri/2019/v27i630187

Quantitative Structure–Activity Relationship and Molecular Docking Studies of Imidazolopyrimidine Amides as Potent Dipeptidyl Peptidase-4 (DPP4) Inhibitors

Leila Emami, Razieh Sabet, Amirhossein Sakhteman & Mehdi Khoshnevis Zade · Journal of Pharmaceutical Research International · 2019

Type 2 diabetes (T2DM) is a metabolic disorder disease and DPP-4 inhibitors are a class of oral hypoglycemic that blocks the dipeptidyl peptidase-4 (DPP-4) enzyme.  DPP-4 inhibitors reduce glucagon and blood glucose levels and don’t have side effects such as hypoglycemia or weigh...

Open access Research Article 10.9734/jpri/2019/v27i630186

QSAR and Docking Study of Isatin Analogues as Cytotoxic Agents

Razieh Sabet, Soghra Khabnadideh, Dara Fathi & Leila Emami · Journal of Pharmaceutical Research International · 2019

Computational chemistry is a unique method in the drug discovery process?? Explain Why?. In this study 109 molecules containing the isatin backbone were subjected to quantitative structure-activity relationship analysis to find the structure requirements for ligand binding. The s...

Open access Research Article 10.9734/jpri/2019/v27i530184

The Association between Placental Location in the First Trimester and Fetal Sex

Fariba Mirbolouk, Maryam Mohammadi, Ehsan Kazemnejad Leili & Seyedeh Fatemeh Dalil Heirati · Journal of Pharmaceutical Research International · 2019

Background: Because advance knowledge of fetal sex can satisfy parental curiosity and allay anxiety, attempts at its determination prior to birth have a long history. There may also be reason to determine fetal sex when sex-specific genetic disorders are suspected. The aim of thi...

Open access Research Article 10.9734/jpri/2019/v27i530183

Anthropometric Parameters in Asthmatic Children and the Relationship of Childhood Asthma with Height, Weight and Body Mass Index

Nasrin Bazargan, Shokouh Hamidifar, Ali Khalouei & Gholamreza Sedighi · Journal of Pharmaceutical Research International · 2019

Background: Asthma as a chronic disease may affect the growth process. The aim of this study was to investigate the anthropometric indices in 2-18 years old children with asthma and compare them with the control group. Patients and Methods: In a case-control study, 150 asthmatic...

Open access Research Article 10.9734/jpri/2019/v27i530181

Evaluation of Emergency Nurses’ Knowledge and Performance about Hospital Triage

Asghar Sherafat, Ali Akbar Vaezi, Mohammadreza Vafaeenasab, Mohammad Hassan Ehrampoush, Hossein Fallahzadeh & Hossein Tavangar · Journal of Pharmaceutical Research International · 2019

Background and Objectives: By knowing the level of knowledge of triage nurses, we will be capable of making the right decision about allocating suitable resources for enriching the quality of the emergency department. So, the objective of our study is to evaluate triage knowledge...

Open access Research Article 10.9734/jpri/2019/v27i530182

Prevalence and Risk Factors of Bacterial Meningitis after Craniotomy in Shahid Bahonar Hospital of Kerman in 2016

Mehdi Ahmadinejad, Yalda Bilesteh & Maryam Ahmadipour · Journal of Pharmaceutical Research International · 2019

Objective: Postoperative infections of the central nervous system are common complications of neurological surgeries, which can lead to bad consequences for the patient and increase the cost of treatment. Incorrect diagnosis or treatment of meningitis after craniotomy can lead to...

Open access Research Article 10.9734/jpri/2019/v27i530180

Comparative Efficacy of 50% Trichloroacetic Acid Solution with 10% Potassium Hydroxide Solution in the Treatment of Plane Warts

Reza Yaghoobi, Nader Pazyar & Bahareh Maleki · Journal of Pharmaceutical Research International · 2019

Background: Warts are very common disorders. Plane warts are caused by Human Papilloma Virus (HPV) occurring mostly in children and young adults. Among the treatment modalities, topical application of trichloroacetic acid (TCA) is age old. Potassium hydroxide (KOH) has a keratoly...

Open access Research Article 10.9734/jpri/2019/v27i430178