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All published articles 7450

Controlled Release Binary and Ternary HPMC-HPC-Gelucire® 50/13 Hybrids Based Solid Dispersions of Indomethacin: In vitro Evaluation and In vivo Anti-inflammatory Studies

J. N. Reginald-Opara, K. C. Ofokansi, F. C. Kenechukwu, C. G. Nwaigwe & A. M. Nnogo · Journal of Pharmaceutical Research International · 2018

Aim: The aim of this study is to formulate and evaluate solid dispersions of indomethacin based on Gelucire 50/13, Hydroxylpropyl methylcellulose and/or Hydroxylpropyl cellulose hybrid binary or ternary system, with a view of enhancing oral bioavailability, sustaining drug releas...

Open access Research Article 10.9734/JPRI/2018/22643

Preoccupations and Worries in Women with Breast Cancer: A Qualitative Study

Shahrbanoo Ghahari, Raheleh Fallah, Leila Behnam, Mohammad Mazloumi Rad, Nazanin Farrokhi & Raoofeh Ghayoomi · Journal of Pharmaceutical Research International · 2018

Aims: As one of the most prevalent cancers among women, breast cancer can severely affect the patients psychologically. Worry and anxiety can be one of these effects. Hence, this study is conducted to evaluate the most important worries and preoccupations of women with breast can...

Open access Research Article 10.9734/JPRI/2018/40229

Formulation and Evaluation of Multi-particulate Drug Delivery System for Metformin Hydrochloride by Spray Drying Method

Abhay Shirode & Vilasrao Kadam · Journal of Pharmaceutical Research International · 2018

Diabetes mellitus is a serious emergency right now which is considered to be one of the major causes of death in all the nations. MET is considered to be one of the major medications to treat type two or insulin dependent diabetes mellitus. Though this process of oral administrat...

Open access Research Article 10.9734/JPRI/2018/39698

Isolation and Characterization of Cola acuminata Gum as a Potential Pharmaceutical Excipient

E. A. Bamigbola, M. A. Momoh & O. Ikebudu · Journal of Pharmaceutical Research International · 2018

Aim: Gums are polysaccharides composed of varying chemical compositions and a wide range of molecular weights. Appropriate evaluation of their physicochemical properties assists in determining their suitability as pharmaceutical excipients in the preparation of various dosage for...

Open access Research Article 10.9734/JPRI/2018/14526

Development and Evaluation of Papaya Peel Powder and Paste Incorporated Chapathis

C. S. Pavithra, S. Suchiritha Devi, W. Jessie Suneetha & Ch. V. Durga Rani · Journal of Pharmaceutical Research International · 2018

Consumption of natural bioactive compounds and dietary fibre offers health benefits and protection against lifestyle diseases. Papaya peel which is discarded waste contributes to environmental pollution, but it can be a good source of minerals, fibre and phenolic compounds with a...

Open access Research Article 10.9734/JPRI/2018/41384

Advances in the Use of Nanoparticles as Anti-Cystic Echinococcosis Agents: A Review Article

Bushra Hussain Shnawa · Journal of Pharmaceutical Research International · 2018

Echinococcus granulosus is the etiological agent of cystic echinococcosis, which is globally distributed and considered as a neglected tropical disease. It is one of the most important zoonotic parasitic infections in both humans and animals. This parasite forms hydatid cysts in...

Open access Research Article 10.9734/JPRI/2018/44642

Vitamin D3 Serum Level Relationship with Severity and Activity of Lupus Disease

Elham Rajaei, Karim Mola, Mehrdad Dargahi-Malamir & Sahar Hatami · Journal of Pharmaceutical Research International · 2018

Background: The importance of vitamin D and its inhibitory effects has been proven in many autoimmune diseases. The present study was conducted to determine the relationship between serum levels of vitamin D3 and the severity and activity of lupus disease. Materials and Methods:...

Open access Research Article 10.9734/JPRI/2018/42473

Pharmaceutical Care Intervention Improves Adherence to Antiepileptic Medication

Eshiet, Unyime Israel, Okonta, J. Matthew & Ukwe, Chinwe V. · Journal of Pharmaceutical Research International · 2018

Purpose: Adherence to the chronic pharmacotherapeutic regimen is poor resulting in negative therapeutic outcomes. Health education has been shown to improve the adherence of patients to their antiepileptic medication. The Pharmacist has the responsibility of providing patient edu...

Open access Research Article 10.9734/JPRI/2018/44377

The Airway Relaxant Effect of Horse Purslane, Trianthema portulacastrum, Linn. (Aizoaceae), is Mediated through Dual Blockade of Muscarinic Receptors and Ca2+ Influx

Samra Bashir, Saima Abbas, Safur Rehman Mandukhail & Anwarul Hassan Gilani · Journal of Pharmaceutical Research International · 2018

Aim: The horse purslane, Trianthema portulacastrum, Linn. (Aizoaceae), is used in traditional systems of medicine for the treatment of asthma. The current investigation was aimed at exploring possible mechanisms underlying the potential bronchodilator effect of Trianthema portula...

Open access Research Article 10.9734/JPRI/2018/44409

Detection Probiotic's DNA of Lactobacillus paracasei in Healthy Human Faeces

Baraa M. Altaha, Jamal Wadi & Asem A. Shehabi · Journal of Pharmaceutical Research International · 2018

Aims: To examine the DNA abundance of the probiotic bacteria (Lactobacillus paracasei) in the faeces of healthy adults after one month of its consumption and to determine the antimicrobial susceptibility profile of this bacteria. Study Design: Thirty apparently healthy adults wer...

Open access Research Article 10.9734/JPRI/2018/44636

Morphine Tolerance Effects on Neurotransmitters and Related Receptors: Definition, Overview and Update

Shima Mehrabadi & Seyed Morteza Karimiyan · Journal of Pharmaceutical Research International · 2018

Morphine is the essential opioid drug that use in the clinic to attenuate chronic and severe pain. However long-term administration of morphine leads to the development of anti-nociceptive morphine tolerance. Mechanisms that involved in morphine tolerance are complicated and affe...

Open access Research Article 10.9734/JPRI/2018/41936

Gestational Exposure to a Commercial Tooth Whitening Agent Containing Carbamide Peroxide Induces Locomotory Changes and Tissue Damage in Mice Newborns

Gadah I. Al-Basher · Journal of Pharmaceutical Research International · 2018

The present study evaluates the impact of gestational exposure to a commercially available tooth whitening agent in mice newborns. A total of 20 male mice and 60 female Swiss albino mice were used in the study. After mating, 30 pregnant mice were obtained which were divided into...

Open access Research Article 10.9734/JPRI/2018/44556

Satisfaction Rate of Clients of Health Houses Affiliated to Dezful University of Medical Sciences

Mostafa Ali Mehr, Hoda Kalhorpour, Vahid Shirani, Niusha Shahidi Sadeghi, Ahmad Moradi & Mehdi Zainivand · Journal of Pharmaceutical Research International · 2018

Introduction and Objectives: Satisfaction rate of clients has a significant effect in higher quality of services provided by employees. Evaluation of health and medical services is the first necessary step in providing services correctly and also satisfaction rate of clients is o...

Open access Research Article 10.9734/JPRI/2018/43727

Anti-infective Therapy Principles in Diseases Caused by Bacterial Biological Agents

Viorel Ordeanu, Marius Necsulescu, Lucia E. Ionescu, Diana M. Popescu, Simona N. Bicheru, Gabriela V. Dumitrescu & Radu G. Hertzog · Journal of Pharmaceutical Research International · 2018

The international situation requires the strengthening of national security measures, including CBRN field and public health. Infectious diseases, and especially infectious-contagious diseases, represent the main threat to public health and have the highest prevalence of morbidit...

Open access Research Article 10.9734/JPRI/2018/43754

Effects of Guided Imagery on Anxiety and Physiological Indicators in In-patients with Acute Coronary Syndrome

Jahanshir Tavakolizadeh, Mehdi Pahlavan, Mahdi Basirimoghadam & Mojtaba Kianmehr · Journal of Pharmaceutical Research International · 2018

One of the most important complaints of patients with the acute coronary syndrome (ACS) is anxiety, whose control is particularly important. The purpose of this study was to determine the effects of guided imagery on state and trait anxiety and their physiological indicators in p...

Open access Research Article 10.9734/JPRI/2018/43592