Aims: The present study was undertaken to understand the need of fed bioequivalence studies for immediate release pharmaceutical products and thereby evaluating the relative appropriateness of guidelines given by the European Medicines Agency (EMA) and the United States Food and...
Open access
Research Article10.9734/BJPR/2014/10496
Aim: A new, simple, rapid, very sensitive and accurate high performance thin-layer chromatographic (HPTLC) method has been developed and validated for estimation of Gemifloxacin in rabbit plasma. Study Design: Validation study. Methodology: HPTLC was performed on silica gel 60F25...
Open access
Research Article10.9734/BJPR/2014/4070
Aims: This study was designed to verify the immunogenicity (potency) and the safety of tetanus toxoid vaccines marketed in three large open drug markets in South-Eastern Nigeria. Methodology: Tests for Sterility, formaldehyde concentrations, specific toxicity, endotoxin, and immu...
Open access
Research Article10.9734/BJPR/2014/10901
Aims: HIV and AIDS spreading wide and causing serious threats and deaths among Malaysian residents. A nationwide cross-sectional survey was conducted to assess the awareness, attitudes and opinions about HIV and AIDS among pharmacy students. Methods: A total of 316 pharmacy stude...
Open access
Research Article10.9734/BJPR/2014/7455
Aims: The crude methanol extract of whole plant of Blumea lacera (Burn.f.) DC. has been investigated for anti-diarrheal, antimicrobial, anxiolytic, anti-atherothrombosis, membrane stabilizing and alpha-amylase inhibitory activities. Place and Duration of Study: The study was carr...
Open access
Research Article10.9734/BJPR/2014/10001
Background: The emergent of many pharmaceutical companies producing their own generic type of drugs after the patent of innovator drugs expired can improve the general healthcare delivery systems as well as decreasing the healthcare costs. But it also raises a few issues with one...
Open access
Research Article10.9734/BJPR/2014/8813
The present study was aimed to investigate the drying kinetics of gum karaya (S. urens). Three grades of gum (I, II, III) were dried using a cabinet-type convective dryer. Particle size equivalent to US Sieve size-6 and air temperatures of 50, 60 and 70°C were used for the drying...
Open access
Research Article10.9734/BJPR/2014/10104
This study was designed to evaluate the anxiolytic effect of methanolic leave extract of Paullinia pinnata L. in mice. The elevated plus-maze and staircase paradigm were used to assess the anxiolytic activity of the methanolic leaf extract of Paullinia pinnata and diazepam. The r...
Open access
Research Article10.9734/BJPR/2014/10990
Aims: To detect the prevalence of biofilm producers among Gram negative bacilli and Gram positive cocci bacterial pathogens along with their antimicrobial susceptibility pattern. Growth and adherence on catheter eluates and in the presence of antibiotics. Methodology: From labora...
Open access
Research Article10.9734/BJPR/2014/9908
Aims: To develop, validate and quantify the content of flavonoids luteolin and apigenin in aerial parts of methanol leaf extract of Bacopa monnieri (B. monnieri) by reverse phase liquid chromatography. Study Design: High Performance Liquid Chromatography Place and Duration of Stu...
Open access
Research Article10.9734/BJPR/2014/9009
Objective: To express a cost efficacious and environment friendly method for the green synthesis of silver nanoparticles (AgNPs) from Catharanthus roseus var. alba (C. roseus var. alba) callus extract. Methodology: The aqueous solution of sliver nitrate containing Ag+ ions (1 mM)...
Open access
Research Article10.9734/BJPR/2014/7785
Liquid chromatography–tandem mass spectrometry (LC–MS/MS) was used for simultaneous quantification of mesalamine and its metabolite N-acetyl mesalamine in human plasma with N-acetyl mesalamine D3 as an internal standard (IS). Chromatographic separation was performed on a Thermo,...
Open access
Research Article10.9734/BJPR/2014/5350
Aim: This study aimed to evaluate the effect of magnesium supplement to atorvastatin on hyperlipidemic patients and to elucidate the possible ability of oral magnesium supplement to counteract or delay statins induced myalgia. Study Design: Forty hyperlipidemic male and female pa...
Open access
Research Article10.9734/BJPR/2014/11145
Aims: To demonstrate the efficacy of five small molecule compounds for inhibiting the growth of Mycobacterium tuberculosis. To present evidence that these compounds will penetrate into the central nervous system. Study Design: Five small molecule compounds bearing a hydrazide gro...
Open access
Research Article10.9734/BJPR/2014/10353
Objectives: To investigate the antimicrobial and cytotoxic activities of crude methanol extract of Curculigo pilosa (Schum and Thonn) Engl. (Hypoxidaceae) rhizomes and its solvent soluble fractions and to analyze the most active fraction by Gas Chromatography Mass Spectrometry (G...
Open access
Research Article10.9734/BJPR/2014/10189