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All published articles 7450

Quantitative Estimation of Piperine and Diosgenin in Ayurvedic Formulation

Sandhya Parameswaran & Shalaka Koshti · Journal of Pharmaceutical Research International · 2014

Goksuradi guggulu is a polyherbal formulation official in “Ayurvedic formulary of India” and used for dysuria, urinary obstruction, increased frequency and turbidity of urine, calculus, excessive vaginal discharge, gout. A simple, specific and precise high performance thin-layer...

Open access Research Article 10.9734/BJPR/2014/8310

Anti-Bacterial Activity of Pigments Isolated From Pigment-Forming Soil Bacteria

Md. Mamunur Rashid, Md. Fakruddin, Reaz Mohammad Mazumdar, Fatema Kaniz & Md. Alimuddin Chowdhury · Journal of Pharmaceutical Research International · 2014

Aims: Search for novel antimicrobials such as bacterial pigments is an issue of priority now. This study aims to isolate pigments with anti-bacterial activity from soil bacteria. Methodology: In this study, Pigment forming bacteria was isolated from soil samples collected from di...

Open access Research Article 10.9734/BJPR/2014/5148

Antiplasmodial Activity of the Root Extracts of Cochlospermum tinctorium in Mice Experimentally Infected with Clinical Isolates of Plasmodium berghei berghei (NK 65)

Rebecca O. Ahmadu, Ezekiel Kogi & Iliya S. Ndams · Journal of Pharmaceutical Research International · 2014

Aims: To determine in vivo the antiplasmodial activity of two chromatographic fractions obtained from Cochlospermum tinctorium A. Rich root bark extract against Plasmodium berghei berghei in mice. Methodology: Two chromatographic fractions were obtained from the crude methanolic...

Open access Research Article 10.9734/BJPR/2014/6861

The Role of Coconut Oil on Pentylenetetrazole Induced Convulsion in Rats: An Electroencephalogram Study

Meraiyebu Ajibola, Olugbemi Olaniyan, Oshimakinde Abiola, A. Seriki Samuel & Okere Shekins · Journal of Pharmaceutical Research International · 2014

Aim: This study was carried out to investigate the role of coconut oil on pentylenetetrazole (PTZ) induced convulsant activity in Wistar rats using the laboratory model. Convulsant activity was achieved by injection of PTZ. Study Design: The rats were divided into five groups. Gr...

Open access Research Article 10.9734/BJPR/2014/4978

Possibilities of Developing New Formulations for Better Skin Protection from a Traditional Medicinal Plant Having Potent Practical Usage

A. Dasgupta, L. Jeyaseeli, A. Mukhopadhyay, S. Palchoudhuri, D. Sinha Roy, B. De & S. G. Dastidar · Journal of Pharmaceutical Research International · 2014

Aims: Natural products obtained from different types of plants have made an important impact since ancient times throughout Asia. Since wood of Hesperethusa crenulata (Roxb.) Roem has been used traditionally by women in Southeast Asia for protection against sunlight and other har...

Open access Research Article 10.9734/BJPR/2014/7636

Cytotoxicity of Enterolobium timbouva Plant Extract and Its Isolated Pure Compounds

Mariam I. Gamal El-Din, Omayma A. Eldahshan, Ashraf B. Abdel-Naim, Abdel-Nasser B. Singab & Nahla A. Ayoub · Journal of Pharmaceutical Research International · 2014

Aims: The present study aimed to evaluate the cytotoxic activities of the aqueous alcohol extract of Enterolobium timbouva leaves as well as its isolated pure compounds. Place and Duration of Study: Department of Pharmacognosy, Faculty of pharmacy, Ain Shams University, between M...

Open access Research Article 10.9734/BJPR/2014/5020

Densitometric and Spectrometric Determinations of Florfenicol and Buparvaquone

Fathalla F. Belal, Sawsan A. Abdel-Razeq, Manal M. Fouad & Fatma A. Fouad · Journal of Pharmaceutical Research International · 2014

Three new accurate and sensitive methods were developed for the determination of two veterinary drugs. Florfenicol was analyzed by a stability-indicating TLC/densitometric method in presence of its amine degradation product obtained via acid hydrolysis. It was based on the differ...

Open access Research Article 10.9734/BJPR/2014/6495

Impact of Highly Active Antiretroviral Therapy (HAART) on Organs of HIV Infected Children in Abia State, Nigeria

M. O. Ajulo, M. K. Omole & J. O. Moody · Journal of Pharmaceutical Research International · 2014

Aim: The aim of the study is to detect effect of zidovudine + lamivudine+nevirapine (AZT+3TC+NVP) on liver and kidney. Study Design: Sixty-four children age 0 to 5 years attending FMC Umuahia were enrolled for the study in four groups. Place of Study: Study was carried out in Ant...

Open access Research Article 10.9734/BJPR/2014/4915

Analgesic, Anti-inflammatory and CNS Depressant Activities of the Methanolic Extract of Abelmoschus esculentus Linn. Seed in Mice

Mst. Luthfun Nesa, Md. Monirul Islam, Md. Badrul Alam, Mst. Shirajum Munira, Shabnam Mollika, Mst. Nazmun Naher & Md. Rafiqul Islam · Journal of Pharmaceutical Research International · 2014

Aims: The study was carried out to assess the analgesic, anti-inflammatory and CNS depressant activity of the methanolic extract of Abelmoschus esculentus Linn. Seeds. Study Design: The Present study was designed to observe pharmacological activities of the crude extract of the p...

Open access Research Article 10.9734/BJPR/2014/7845

Phytomedicines of Sickle Cell Crisis in Mezam Division, Cameroon: Preventive and Curative Cares

Noumi Emmanuel & NFORBI Akonwi Ngwa Nebane · Journal of Pharmaceutical Research International · 2014

Background: The aim of this study was to survey the Mezam Division of Cameroon, with a view to documenting how the population of that area treat sickle cells disease using medicinal plants, and to determine the need for further information on sickle cell disease or sickle cell an...

Open access Research Article 10.9734/BJPR/2014/4959

Antioxidant and Cytotoxic Activity of Crude Flavonoid Fraction from the Fruits of Hybrid Variety of Momordica charantia (Bitter Gourd)

Rashu Barua, Samsad Sultana, Md. Ehsan Uddin Talukder, Kanchan Chakma, Chowdhury Mohammad Monirul Hasan & Mohammad Sayedul Islam · Journal of Pharmaceutical Research International · 2014

Aims: The study was conducted to evaluate the antioxidant and cytotoxic properties of crude flavonoid fraction from hybrid variety of Momordica charantia (L.) (Bitter gourd) fruit. Place and Duration of Study: The study was carried out in 2011 in the Department of Biochemistry an...

Open access Research Article 10.9734/BJPR/2014/7288

Design, Synthesis, Biological Evaluation and Docking Studies of Some New Diclofenac Analogues

Hassan A. Osman & G. M. Nazeruddin · Journal of Pharmaceutical Research International · 2014

Aim: There is still a need for new, selective COX-2 inhibitors with an improved safety profile, therefore, a series of diclofenac analogues were designed and different physicochemical properties were calculated such as log P, hydrogen donor, hydrogen-acceptor, molecular weight an...

Open access Research Article 10.9734/BJPR/2014/5030

Prophylactic Effect of Clofibrate on Hyperbilirubinemia in Very Low Birth Weight Twins

Mohammadzadeh Ashraf, Farhat Ahmadshah, Esmaeli Habibullah & Javanrouh Niloofar · Journal of Pharmaceutical Research International · 2014

Aims: To determine the prophylactic effects of clofibrate on hyperbilirubinemia in very low birth weight twins. Study Design: A randomized double blind clinical trial Place and Duration of Study: Department of Neonatal Research Center, Imam Reza Hospital, Faculty of Medicine, Mas...

Open access Research Article 10.9734/BJPR/2014/5264

Comparative Study of Anticonvulsant Property among Different Fluoro Substituted Synthesized Benzothiazole Derivatives

I. Shanmukha, A. M. Madhusudhana, E. Jayachandran, M. Vijay Kumar & B. Prakash · Journal of Pharmaceutical Research International · 2014

Objective: The present study is to evaluate antiepileptic activity of some fluoro benzothiazolo oxadiazolo quinazoline and sulfonamido quinazoline derivatives. Background of the Study: Epilepsy is a chronic disorder of the brain, characterized by the periodic and unpredictable oc...

Open access Research Article 10.9734/BJPR/2014/6876

Comparative Phytochemical Screening and In vitro Evaluation of Biological Activities between Aqueous and Ethanolic Extract of Momordica charantia L. Fruits

Abhijit Das, Palash Karmakar, Md. Golam Kibria, Pankaj Chandra Debnath, Mohammad Safiqul Islam & Mohammad Mafruhi Sattar · Journal of Pharmaceutical Research International · 2014

Aims: The study was conducted to compare the presence of different phytochemicals and biological activities like cytotoxicity, anthelmintic activity, antioxidant and free radical scavenging activities between aqueous and ethanolic extract of Momordica charantia L. Fruits. Methodo...

Open access Research Article 10.9734/BJPR/2014/7364