Petroleum ether, chloroform and methanol extracts of the whole plant of Artemisia maritima Linn were studied in vitro and in vivo for antitrypanosomal activity against Trypanosoma brucei brucei in Swiss albino mice. The extracts were also screened for phytochemicals/secondary met...
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Research Article10.9734/BJPR/2014/7631
Background: Medicinal herbs have long been used in the treatment of malaria in the endemic tropical and subtropical regions of the world, especially in sub-Saharan Africa where malaria has remained as a top killer disease to children under five years and expectant mothers. Among...
Open access
Research Article10.9734/BJPR/2014/6528
Background: Reports of adverse drug reactions (ADR) in the era of increasing uptake of antiretroviral drugs particularly in Sub Saharan Africa and especially in Nigeria have been on the rise. Aim: We set out to collate and characterize the pattern of adverse drug reactions in pat...
Open access
Research Article10.9734/BJPR/2014/6520
Aims: Darunavir is widely used in HIV/AIDS therapy. It is a HIV protease inhibitor that has excellent efficacy against the virus. The aim of this study is to develop and validate an analytical method fast and free of interferences for determination of darunavir ethanolate as raw...
Open access
Research Article10.9734/BJPR/2014/6326
In rural Africa, a number of alternative treatment options are explored because of poverty and unawareness. Kerosene is one such agent used for the treatment of a myriad of diseases. The aim of the study was to investigate the effects of trace amounts of kerosene on lung, heart,...
Open access
Research Article10.9734/BJPR/2014/2983
Aims: To screen Streptomyces sp. from saline soil in Pakistan, for its antimicrobial activity and to purify and identify the active metabolites produced by mass spectrometry and NMR spectroscopy. Strain identification by morphological, biochemical, physiological characterization...
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Research Article10.9734/BJPR/2014/5721
Aims: To establish and optimize the in vitro antioxidant activity of methanolic extract of flower of C. guianensis at different developmental stages. Place and Duration of Study: Plant Physiology and Pharmacognosy Research Laboratory, Department of Botany, University of North Ben...
Open access
Research Article10.9734/BJPR/2014/8106
Aims: To evaluate the anthelminthic activity of Annona reticulata seeds extracts against Pheretima posthuma. Study Design: Helminth infections have tormented humans and animals for thousands of years. The indiscriminate uses of the anthelminthic drugs have lead to the emergence o...
Open access
Research Article10.9734/BJPR/2014/6055
Aims: This study aimed at preparing pharmaceutical gels containing Glyccerihizic Acid Ammonium Salt (GAM) for healing of chronic wounds followed by in-vitro and in-vivo characterization of the prepared gels to ensure their suitability, efficacy and safety. Place and Duration of S...
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Research Article10.9734/BJPR/2014/7591
Differential first derivative (ΔD1) method is developed for the quantitative analysis of cefquinome sulphate (CS) in bulk and dosage form. The method is based on measuring the ΔD1 of CS in alkaline solutions against its neutral aqueous solutions as blanks. The proposed method is...
Open access
Research Article10.9734/BJPR/2014/5734
Objective: To evaluate the antioxidant potential of lectin from the endophytic fungi of Viscum album. Place and duration of study: Department of Biotechnology, Shridevi Institute of Engineering and Technology campus, Tumkur, Karnataka, India between November 2012 and March 2013....
Open access
Research Article10.9734/BJPR/2014/6702
The methanol and aqueous extracts of the leaves, fruits, seeds, stem bark and roots of Picralima nitida were studied in vitro and in vivo for activity against Trypanosoma brucei brucei in Swiss albino mice. Phytochemicals studies were also conducted for all the plant extracts The...
Open access
Research Article10.9734/BJPR/2014/6628
Aims: To investigate the antipyretic effect of ethanol extract of Curcuma zedoaria Rosc. (Zingiberaceae) rhizome in animal model. Study Design: Extraction of plant constituents and evaluation of elevated body temperature lowering activity. Place and Duration of Study: Department...
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Research Article10.9734/BJPR/2014/7225
Aims: The present study was done to evaluate the antidepressant-like effect of Celastrus paniculatus seed oil in Swiss young albino mice subjected to chronic unpredictable mild stress. Study Design: Prospective. Place and Duration of Study: Department of Pharmaceutical Sciences,...
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Research Article10.9734/BJPR/2014/5677
Aims: To evaluate the antiplasmodial efficacy of stem bark extracts of P. kotschyi against P. berghei berghei in mice. Study Design: Extraction and administration of plant extracts and evaluation of daily parasitaemia of infected mice. Place and Duration of Study: Department of P...
Open access
Research Article10.9734/BJPR/2014/2809