Aims: The role of thyroid hormones as important mediator of glucose metabolism and body weight dynamics had long been established. This study was therefore designed to evaluate the effect of standard thyro-active drugs in comparison to crude nutritional extracts, on blood glucose...
Open access
Research Article10.9734/BJPR/2014/5665
Aims: This study focused on comparing binary and ternary solid dispersions (SD's) of water-insoluble Tamoxifen citrate (TMC) regarding drug dissolution and oral bioavailability. Basically, the enhanced dissolution of this drug by water-soluble polymer has not yet been reported in...
Open access
Research Article10.9734/BJPR/2014/6072
The study aims at determining the antisicking effectiveness of the extracts of the leaves of a herbal medicinal plant Alchornea cordefolia. The plant is widely distributed in the South-eastern region of Nigeria. The study is designed to involve phytochemical exploration, the nutr...
Open access
Research Article10.9734/BJPR/2014/4467
Introduction: Many diseases are associated with oxidative stress caused by free radicals. Current research is directed towards finding naturally occurring antioxidants of plant origin. Xanthium strumarium L. a cocklebur or bur weed is a reputed medicine in Europe, China, Indo-chi...
Open access
Research Article10.9734/BJPR/2014/3667
Aims: To investigate the phytochemical, antioxidant and antibacterial activities of the solvent extracts of wild grape fruits in different colors. Study Design: The solvent extracts of wild grape (Ampelocissus martinii Planch.) fruits were prepared by mixing grinded fruit in each...
Open access
Research Article10.9734/BJPR/2014/5626
Objective: The objectives of this study were to identify stable anhydrous emulsions via pseudo ternary phase diagram, optimize artemether-loaded batches using factorial design and subsequently evaluate the antimalarial activity. Methodology: Using labrasol®, triacetin® and laurog...
Open access
Research Article10.9734/BJPR/2014/5279
Aims: Oxcarbazepine was formulated as suspension in order to perk up the palatability, augment bioavailability of the product, furthermore extended to estimate good degree of in vitro in vivo correlation (IVIVC). Study Design: Formulation and Evaluation of Oxcarbazepine Suspensio...
Open access
Research Article10.9734/BJPR/2014/4763
Background: Information on economic burden of hypertension is needed for relevant decisions and policies due to escalating cost of disease management. Aims: The study assessed economic burden of pharmacotherapy in hypertension management on the National Health Insurance Scheme (N...
Open access
Research Article10.9734/BJPR/2014/3983
Aims: Stability indicating densitometry-TLC assay was established and validated for determination of azelastine hydrochloride (AZT) and emedastine difumarate (ETD) in the presence of their acid and oxidative degradants. Methodology: Forced degradation was performed using 30% H2O2...
Open access
Research Article10.9734/BJPR/2014/3693
In order to evaluate the synergistic action of essential oils (EO) on the antifungal activity of honey, a comparative method of adding honey with and without EO to culture media was used. One variety of honey and five EO types were used to determine the minimum inhibitory concent...
Open access
Research Article10.9734/BJPR/2014/5332
Aims: Misuse of antimicrobial medicines is a major contributory factor to development of resistant strains of micro-organisms, therapeutic failure and increased healthcare costs in many countries. To identify pattern of antimicrobial use among undergraduate students of the Univer...
Open access
Research Article10.9734/BJPR/2014/5972
Objective: To evaluate the role of anti-depressants (Duloxetine) and NSAID (Dexibuprofen) in a new rat model of chronic induced depression. Methods: Twenty four male wistar rats were divided into 4 groups of 6 animals each. Group I to IV served as vehicle control, osteoarthritis...
Open access
Research Article10.9734/BJPR/2014/4040
Aims: The leaves of Gmelina arborea (ROXB.) (Family Verbenaceae) are widely used in the folklore to treat various types of diseases. In this study, the antioxidant and cytotoxic activities of different methanolic extracts and the derived subfractions of 90% methanolic extract of...
Open access
Research Article10.9734/BJPR/2014/6018
Aims: Sequel to the resurgence of TB co-infection in HIV/AIDS patients in sub-Saharan Africa, efavirenz has become an important component of the highly active antiretroviral treatment (HAART). The objective of this study therefore is to provide a simple reversed-phase high perfor...
Open access
Research Article10.9734/BJPR/2014/4123
Objectives: To evaluate possible ocular hypotensive effect of 0.5% diltiazem and 0.1% verapamil eye drops on intraocular pressure in steroid induced glaucoma model of rabbits. And compare with 0.5% timolol eye drops. Methodology: Glaucoma was induced in rabbits (N=18) by bilatera...
Open access
Research Article10.9734/BJPR/2013/4389