The effect of paraquat on Clarias gariepinus (220.50 ± 15.33g mean weight and 30.43 ± 1.22cm mean total length) was examined by the assessment of the organ indices and haematological parameters after twenty one days of exposure. It was observed that paraquat caused decline in the...
Open access
Research Article10.9734/BJPR/2013/3647
Aim: The present study was undertaken to evaluate the antidiabetic effects of the Tamarindus indica Linn seed in normal (non-diabetic), type-I and type-II model rats and to investigate their effect on gastrointestinal motility and intestinal glucose absorption. Methodology: T. in...
Open access
Research Article10.9734/BJPR/2013/4865
Aims: The purpose of this research is to develop a novel expandable gastroretentive dosage form (GRDF), based on unfolding mechanism. It consists of a drug loaded bilayer polymeric film, folded into a hard gelatin capsule. Gastric retention is achieved due to unfolding of the dos...
Open access
Research Article10.9734/BJPR/2013/4891
Aims: To formulate and characterize GLB-PEG-LEC NCs (lecithin complexed Glibenclamide nanocrystals) and to analyze the effect of PEG 20000 and lecithin on drug properties, particle size reduction and stability of GLB NCs. Study Design: Precipitated (GLB-PEG) and complexed nanocry...
Open access
Research Article10.9734/BJPR/2013/5515
Aims: Hiptage benghalensis is used in the traditional system of medicine. The leaf is considered one of the important plant organs for the treatment of various diseases such as rheumatism, leprosy, wounds, ulcer, burning sensation, scabies, inflammation and cough. Hence, the pres...
Open access
Research Article10.9734/BJPR/2013/4454
Aims: Brain and spinal cord tumors are the third most common type of childhood cancer following leukemia and lymphoma. Mechlorethamine (or mustine) is a nitrogen mustard antineoplastic drug. Eleven variants of mechlorethamine are presented that possess molecular properties enabli...
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Research Article10.9734/BJPR/2013/5761
Aims: To investigate the effect of ethanol extract of Coccinia grandis Lin (Cucurbitaceae) leaf in glucose and cholesterol lowering activity in animal model. Study Design: Extraction, glucose and cholesterol lowering activity evaluation. Place and Duration of Study: Department of...
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Research Article10.9734/BJPR/2013/4583
Aims: The objective of the present study was to develop a bioadhesive bilayered buccal patch of Nimodipine (15 mg) using Eudragit Rs 100 as secondary layer and a primary layer with Hydroxy propyl methyl cellulose and Hydroxy propyl cellulose JF. Methodology: Bilayered buccal patc...
Open access
Research Article10.9734/BJPR/2013/5670
Aims: Tinea corporis & cruris of skin respond well to topical antifungal therapy, but there is a need to apply cream 2- 3 times daily for up to four weeks will impair compliance & lead to treatment failure. Luliconazole is one of those drugs offering good efficacy & t...
Open access
Research Article10.9734/BJPR/2013/4348
Aims: Roflumilast is a phosphodiesterase-4-inhibitor used as add-on therapy to long-acting bronchodilators in chronic obstructive pulmonary disease. Although roflumilast is well tolerated, there have been concerns regarding psychiatric problems, including suicide tendencies. This...
Open access
Research Article10.9734/BJPR/2013/5633
The vagina provides a promising site for local effect as well as systemic drug delivery because of its large surface area, rich blood supply, avoidance of the first-pass effect, relatively high permeability to many drugs and self-insertion. The pharmaceuticals currently used for...
Open access
Research Article10.9734/BJPR/2013/3895
Objective: This study evaluated acute and sub-acute toxicities in rodents and microbial purity of a polyherbal formulation, Bobwell® popular among the natives for the management of diabetes mellitus (DM). It was prepared with unspecified quantities of the following plant material...
Open access
Research Article10.9734/BJPR/2013/4117
This research investigated the antioxidant potential of Momordica charantia fruit extracts in ethanol and ethyl acetate. The extracts have been assessed for DPPH free radical scavenging effect, FeCl3 reducing power and superoxide scavenging effect. In DPPH method IC50 value of as...
Open access
Research Article10.9734/BJPR/2013/4722
Aims: Aim of this study was to evaluate the comparative efficacy of Tinospora cordifolia (Willd.) Miers ex Hook. F., Tinospora sinensis (Lour.) Merrill and T. cordifolia growing on Neem (Azadirachta indica A. Juss.) called Neem-guduchi. Study Design: Selected species have been wi...
Open access
Research Article10.9734/BJPR/2013/4003
Aim: Carry out preliminary phytochemical screening of Balanites aegyptiaca fruit mesocarp and to evaluate the ability of the aqueous extract to ameliorate carbon tetrachloride-induced hepatotoxicity in rats by determining liver enzymes, blood parameters and histopathology. Study...
Open access
Research Article10.9734/BJPR/2013/4576