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Isolation and In Silico Characterization of Defensin Genes from Some Indigenous Plant Species of Pakistan

M. Aslam, F. Hussain, N. Ahmed & A. Jamil · Journal of Pharmaceutical Research International · 2022

Aims: Damage of crop plants due to pathogenic attacks, postharvest crops spoilage and lethal effects of chemical pesticides has enforced scientists to find some potential natural alternative. Plants produce different types of antimicrobial peptides including defensins in response...

Open access Research Article 10.9734/jpri/2022/v34i41B36280

US FDA Regulatory Framework for Generic Peptides Referring to rDNA Origin Reference Products

Ankit Chincholkar, Deepak Khobragade & Swanand Pathak · Journal of Pharmaceutical Research International · 2022

Peptides are polymeric molecules having 40 or less amino acids. Peptides have been used as therapeutic compounds for the treatment of various disorders since 1920s. Initially, these were isolated from animals. Currently, most of the therapeutic peptides are either synthetic or pr...

Open access Research Article 10.9734/jpri/2022/v34i41A36276

Prevalence of Maternal Complications after Caesarean Section in Women with Abnormal BODY MASS INDEX (BMI)

Shahida Karamat, Sana Mubarik, Naeem Akhtar Khokhar, . Resham, Asifa Abdul Jabbar & Nusrat Khatoon · Journal of Pharmaceutical Research International · 2022

Objective: To determine the frequency and maternal complications of cesarean section in women with BMI >25 kg/m2. Methodology: This descriptive Case series was done at the Gynaecology  and Obstetric Unit III, Civil Hospital Karachi for 6 months i.e. May - Nov 2013. Total 164 o...

Open access Research Article 10.9734/jpri/2022/v34i41A36275

Frequency of Cardiomyopathy in Children having Thalassemia Major: A Cross-Sectional Study

Abdul Rauf Jamali, . Mujeeb-u-Rehman, Ram Chand, Dilawar Khan Jokhio, Naseem Ahmed Kubar, Naseer Ahmed Memon & Muhammad Nadeem Chohan · Journal of Pharmaceutical Research International · 2022

Aim: To determine the frequency of cardiomyopathy in children having Thalassemia major diagnosed on the basis of Echocardiography. Study Design: A cross-sectional study. Place and Duration: Paediatric department at Peoples medical college hospital (PMCH), Nawabshah from September...

Open access Research Article 10.9734/jpri/2022/v34i41A36277

Assessment of the Compliance of Statin Treatment in Hyperlipidemic Patients and its Association with Socioeconomic Status

Noreen Irum, Masood Ahmed Unar, Kamlesh Kumar Ahuja, Waseem Raja Memon, Muhammad Umair Farooqui, Anwar Ali Jamali & Arslan Ahmer · Journal of Pharmaceutical Research International · 2022

Objectives: To assess the compliance of statin treatment in hyperlipidemic patients and its association with Socioeconomic Status in Nawabshah, Sindh, Pakistan. Methodology: This was a retrospective cross-sectional study using convenient sampling technique conducted in collaborat...

Open access Research Article 10.9734/jpri/2022/v34i41A36278

Impact of Comorbid Conditions in COVID-19 Treatment

Touseef Ahmed, Toqeer Hussain, Maryem Arif, Nadeem Iqbal & Zubair Ahmed Khoso · Journal of Pharmaceutical Research International · 2022

In 2019, an outbreak known as SARS-CoV-2 spread all over the World from China city Wuhan. This epidemic rapidly spread throughout the world from that day, affecting 180 nations. Individuals of all ages were involved in this outbreak, and this spread at a high rate. COVID-19 is th...

Open access Research Article 10.9734/jpri/2022/v34i41A36272

Effectiveness of Oral Probiotics in Prevention of Necrotizing Enterocolitis in Preterm Infants

Naheem Ahmed, Tayyaba Siddique, Muhammad Aftab, Kiran Ashfaq Ahmed, Amna Mateen & Rashada Bibi · Journal of Pharmaceutical Research International · 2022

Objective: To determine the efficacy of probiotics in the prevention of necrotizing enterocolitis in preterm infants. Materials And Methods: This randomized controlled trial was conducted at the paediatric department of CMH Muzaffarabad AJK. All preterm bottle and NG-fed neonates...

Open access Research Article 10.9734/jpri/2022/v34i41A36268

Costus afer Ker Gawl (Costaceae): A Review on Its Medicinal uses with Focus on Potential Anti-Inflammatory Effect

Jean-Paul Nzambi Divengi, Assumani Zabo Idrissa, Dorah Mwenyi Kabasele, Patience Lunkondo Mbuyi, Innocent Shongo Walle, Victorine Mbo Lesse, Randy Isaya Kiala, Philipe Sansi Nzinga, Richard Mananga Bongo, John Za nza Ntezolo, Florent Biduaya Mukeba, Benjamin Mbenza Longo, Paulin Kapepula Mutwale, Gauthier Kahungu Mesia & Gaston Lutete Tona · Journal of Pharmaceutical Research International · 2022

More than 80% of the population in Africa by the World Health Organization (WHO) leans on endogenous knowledge to solve their primary health care problems. In this study, we examined the relevance of Costus afer Ker Gawl, a plant called ginger lily, spiral ginger or bush cane. It...

Open access Research Article 10.9734/jpri/2022/v34i41A36269

Rapid Rehabilitation in Urological Surgery with Psychological and Preoperative Care

Muhammad Abbas, Wang Zhe, Hafiz Usman Ghani, Rafi Ullah, Hammad ur Rehman & Zeeshan Bashir · Journal of Pharmaceutical Research International · 2022

Urological surgery patients will be studied to see whether a combination of rapid recovery surgery and psychological nursing might help them recover more quickly. Methods There were 74 patients identified and treated in our urological surgery department between April 2020 to Apri...

Open access Research Article 10.9734/jpri/2022/v34i41A36270

A Meta-analysis of the Effect of Selective Serotonin Reuptake Inhibitors on Pain in Fibromyalgia

Ruoa Faisal Albunayyan · Journal of Pharmaceutical Research International · 2022

Background: Fibromyalgia is a clinical condition that causes wide spread severe pain, sleep problems, fatigue, and often emotional and mental distress. Patients with fibromyalgia may be more sensitive to pain than others. Aim: This study aims to screen and evaluate the efficacy a...

Open access Research Article 10.9734/jpri/2022/v34i40B36267

Spread of Mesalazine Rectal Foam after Single Dose in Mild Ulcer Patients

K. Rakesh, K. Kumaresan, S. Prameelarani, M. Salman, S. Kamireddy, S. V. S. Attili & Rakesh Sharma · Journal of Pharmaceutical Research International · 2022

Background: The rectal foam enemas were used for ulcerative colitis of distal regions due to its desired efficacy and less side effects. The spread and persistence of the drug plays a key role in the treatment. Therefore, the objective of the present study is to study the spread...

Open access Research Article 10.9734/jpri/2022/v34i40B36265

Pregnancy (Maternal and Fetal) Outcome in Women Who Used Smokeless Tobacco: A Cross-sectional Study

Shehreen Memon, Sanam Channa, Nadia Hameed, Yasmeen Bibi & Muhammad Nadeem Chohan · Journal of Pharmaceutical Research International · 2022

Aim: To assess the pregnancy (maternal and fetal) outcome in pregnant women who used smokeless tobacco in tertiary care hospital. Study Design: A cross-sectional study. Place and Duration: Department of Obstetrics and Gynecology, LUMHS, Jamshoro/Hyderabad from August 2016 to Febr...

Open access Research Article 10.9734/jpri/2022/v34i40B36266

Emotional and Therapeutic Elements of Cigarette Smoking Control: A Cross Sectional Study

Usman Latif, Syeda Arooj Fatima, Hassan Daniyal, Fatima Maham Iqtidar, Chaudhary Muhammad Salman & Muhammad Yasir · Journal of Pharmaceutical Research International · 2022

Aim: The aim of this study was to investigate the impact of services rendered by health professionals in reducing cigarette smoking at the smoking cessation centers. Methods: Through May 2020 and April 2021, data from hospitals connected with the University of Health Sciences, La...

Open access Research Article 10.9734/jpri/2022/v34i40B36259

Endophytic Fungi and Phytochemical Profile of Withania somnifera

Sabrin Afroz Riya & Md. Hossain Sohrab · Journal of Pharmaceutical Research International · 2022

Withania somnifera (Ashwagandha) is used in medicine from the time of Ayurveda. The roots of the plant are used traditionally in the treatment of nervous and some other disorders. Several effects like immunomodulation, hypolipidemic, antibacterial, cardiovascular protection, tole...

Open access Research Article 10.9734/jpri/2022/v34i40B36261