Aubin N’GUESSAN, Ludovic Akonan, Désiré MELEDJE, Hermann N’Guessan, Gabin Placide ALLANGBA, Logbo MOUSSE, Nahossé Ziao, Melalie Keita, Raymond KRE & Eugene Megnassan·Journal of Pharmaceutical Research International·2025
This study developed a random forest (RF) model based on a large and diverse dataset to classify whether organic chemicals or drugs are respiratory toxicants. Indeed, the concerns regarding drug-induced respiratory remain a major cause of drug candidate failure in clinical trials...
Open access
Research Article10.9734/jpri/2025/v37i127774
Nicholas Muparadzi, Waraidzo Juliet Nyatsine, Ropafadzo Madondo, Daisy Kudzai Kahwenga, Tinashe Goronga, Alfredy Tapiwa Chidyiwa & Kurai Gareth Mawoneke·Journal of Pharmaceutical Research International·2025
Drug and substance abuse is a growing public health threat in Zimbabwe, with potential to affect the economic growth of the nation. Globally, there is an increase in the number of people who use drugs. In 2013, UNODC estimated that 246 million people had used a drug in the previo...
Open access
Research Article10.9734/jpri/2025/v37i117773
Aims: Different types of drug release modifying polymers, their grades and quantities have to be optimised in the formulation considering solubility characteristics and biological half-life of the drugs. Further, formulations containing such discrete ingredients processed by conv...
Open access
Research Article10.9734/jpri/2025/v37i117772
Future medical equipment is being gradually shaped by artificial intelligence, which offers accuracy, personalization, and efficiency in healthcare. By improving patient outcomes and enhancing surgical and diagnostic precision, artificial intelligence (AI) is transforming orthope...
Open access
Research Article10.9734/jpri/2025/v37i117771
Background: Raspberry Ketone (RK, 4-(4-hydroxyphenyl)butan-2-one) is a naturally occurring phenolic compound in various fruits (e.g., raspberry, peach). Recent years have seen multidisciplinary research interests into its chemical properties, mechanistic pharmacology, safety prof...
Open access
Research Article10.9734/jpri/2025/v37i117770
The most prevalent cancer in children is acute lymphoblastic leukemia (ALL), and relapsed or refractory illness still poses a significant therapeutic challenge. Because chimeric antigen receptor T-cell (CAR-T) therapy reroutes autologous T cells to identify and eliminate cancerou...
Open access
Research Article10.9734/jpri/2025/v37i117769
Vytheeswari Kadhirvel, S Angala Parameswari, S S Rajendran, T Anu Yashika, S Nandhini, A Archana, M Chandru, M. Radhini & Neelaveni Thangavel·Journal of Pharmaceutical Research International·2025
The combination of Artificial Intelligence (AI) and nanotechnology is transforming the development of modern pharmaceutical and medical devices. This review explains how nanomaterials—because of their small size, high surface area, and strong interaction with biological systems—i...
Open access
Research Article10.9734/jpri/2025/v37i117768
Pyriform sinus carcinoma, a common hypopharyngeal malignancy, often presents late due to the silent progression of symptoms and early submucosal spread. We report the case of a 55-year-old male who presented with progressively enlarging neck swelling for 10 months. Clinical evalu...
Open access
Research Article10.9734/jpri/2025/v37i117767
Background: Phenylephrine (PE) is a non-prescription decongestant listed on the Australian Register of Therapeutic Goods (ARTG). However, there are no published systematic reviews supporting the efficacy and safety of this product for this use. Objective: This review examine the...
Open access
Research Article10.9734/jpri/2025/v37i117766
Advanced electrochemical sensors offer great opportunities to detect active pharmaceutical ingredients using interactions between nanomaterials and target analytes. Miniaturization of these sensors, wireless data transmission, and sensitivity are important research areas. The int...
Open access
Research Article10.9734/jpri/2025/v37i117765
Aims: The emergence of viral infections highlights the urgent need to develop new antiviral molecules. This study is part of an effort to explore the antiviral properties of medicinal plants used in traditional pharmacopoeia in Côte d'Ivoire. The main objective was to evaluate th...
Open access
Research Article10.9734/jpri/2025/v37i117763
Paul Chinwuba, Chimaobi O. Ugorji, Daniel L. Ajaghaku, Winifred O. Amattah, Amara A. Ajaghaku, Onyesife C. Obiageli, Zogini U. Confidence, Victor T. Ezeifeh & Okoro O. Kingsley·Journal of Pharmaceutical Research International·2025
Neuroinflammation driven by the NLRP3 inflammasome is a key mechanism in many neurological disorders. While plant-derived polyphenols and terpenoids individually show anti-inflammatory potential, their synergistic effects remain underexplored. This review highlights the enhanced...
Open access
Research Article10.9734/jpri/2025/v37i117762
Patients suffering from obesity are more susceptible to comorbidities (diabetes, hypertension and dyslipidemia), physical disabilities, and low self-esteem, with subsequent reduced quality of life (QoL). Bariatric surgery (BS) has evolved among medical surgeons as an effective tr...
Open access
Research Article10.9734/jpri/2025/v37i117761
Edna Alcantara-Fierro, Rodolfo Pinal, Efrén Hernandez-Baltazar, Sergio Alcala-Alcala, Teresa Carvajal, Fernando Alvaréz-Nuñez & Mariana Ortiz-Reynoso·Journal of Pharmaceutical Research International·2025
The formulation of hydrophobic drugs, such as terbinafine hydrochloride (TbHCl), presents significant challenges due to their low aqueous solubility, which severely limits oral bioavailability. This study explores the application of hot-melt extrusion (HME) to enhance the dissolu...
Open access
Research Article10.9734/jpri/2025/v37i107760
The advancement of green technology has heightened interest in creating low-cost, environmentally friendly methods for fabricating nanoparticles. Copper oxide nanoparticles (CuO-NPs) have received a considerable attention due to their electrical, catalytic, optical, textile, phot...
Open access
Research Article10.9734/jpri/2025/v37i107758