Coronal fractures of the permanent dentition are the most common type of dental damage. Certain injury types fall under the category of endodontic emergencies and demand immediate intervention. If the original tooth fragment is retained after fracture, the natural tooth structure...
Open access
Research Article10.9734/jpri/2025/v37i107759
The emergence of antibiotic resistance has intensified the need for novel antimicrobial agents from marine sources. Barnacles (Balanus spp.), being sessile organisms, develop potent chemical defences against microbial colonization, making them promising candidates for marine biop...
Open access
Research Article10.9734/jpri/2025/v37i107757
Utilization of herbal gel has increased now a days because of fewer side effects in comparison to allopathic gel. Plant extracts-based gels possessing antibacterial properties are in a great demand because of skin protective and skin caring action. Aim: Purpose was to formulate a...
Open access
Research Article10.9734/jpri/2025/v37i107756
Migraine is a multifactorial neurovascular disorder involving aberrant neuronal excitability, vascular dysregulation, and neuroinflammation. Current therapies often provide incomplete relief and may cause adverse effects, highlighting the need for safer, multi-target intervention...
Open access
Research Article10.9734/jpri/2025/v37i107754
Hannah Ndidiamaka Okorie, Chigozie Peace Okorie, Goodnews Onyedikachi Ikeh, Angel Chihurumnanya Leonard, Nwoke Obinna Chidubem, Igwe Chidiebere Collins & Anthony A. Attama·Journal of Pharmaceutical Research International·2025
Nanoparticles (NPs), ranging from 1–100 nm, exhibit unique properties due to their compact atomic arrangement, enhancing mechanical, electrical, magnetic, optical, catalytic, and antibacterial characteristics compared to macroscopic materials. The rising threat of multidrug-resis...
Open access
Research Article10.9734/jpri/2025/v37i107755
Ndifor Rose Nchang, Kada Antoine Sanda, Bih Belta Lilian Fubi, Tangu Patience Neng, Mumbi Laurantine Ngenteh, Kiafon Betrand Nsah & Oumar Mahamat·Journal of Pharmaceutical Research International·2025
Aims: Depression causes wide changes in the brain and blood parameters. This study investigated the effect of the ethanol extract of Gladiolus aequinoctialis (G. aequinoctialis) in regulation of hormones and neurotransmiiters balance in depressed Wistar rats. Methodology: Depress...
Open access
Research Article10.9734/jpri/2025/v37i107753
Liver diseases hinders normal hepatocellular functions and is responsible for about 2 million deaths and account for 4% of global mortality. One of the causes of liver disease is increase in adrenergic activity and subsequent release of large amount of catecholamines. Adrenaline...
Open access
Research Article10.9734/jpri/2025/v37i107752
Chigozie Peace Okorie, Hannah N. Okorie, Goodnews Onyedikachi Ikeh, Kennedy Oluigbo, Goldy Iruoma Ani, Nwoke Obinna Chidubem & Nwoke Nwabunwanne Chukwudi·Journal of Pharmaceutical Research International·2025
Haemorrhoids, characterised by inflamed and swollen anorectal veins, represent a significant global health burden, with profound impacts in regions with limited healthcare access, such as Nigeria and sub-Saharan Africa. Globally, the prevalence of haemorrhoids is estimated at 4.4...
Open access
Research Article10.9734/jpri/2025/v37i107751
This study investigated the therapeutic potential of apocynin in mitigating obesity-induced cardiovascular dysfunction. With cardiovascular disease mortality projected to reach 22.2 million by 2030 and obesity recognized as a significant predisposing factor, the research addresse...
Open access
Research Article10.9734/jpri/2025/v37i107750
A systematic Intrinsic network pharmacology methodology was employed to determine the multi-target therapeutic activity of Rosmarinic acid in endometritis. Prediction of target proteins was performed using Swiss Target Prediction and PharmMapper, followed by protein–protein inter...
Open access
Research Article10.9734/jpri/2025/v37i97748
Solanum americanum, a medicinal plant traditionally used to treat inflammation, anemia, and kidney disorders, was evaluated for its antioxidant, anti-arthritic, anti-struvite, and anti-sickling properties. Methanolic extracts of S. americanum leaves (MESAL) were prepared and test...
Open access
Research Article10.9734/jpri/2025/v37i107749
Aim: To compare and assess the efficacy of preoperative submucosal injection of 8 mg dexamethasone versus 40 mg methylprednisolone for bilaterally symmetrical impacted mandibular third molar surgery. Materials and Methodology: The study was conducted on the subjects requiring sur...
Open access
Research Article10.9734/jpri/2025/v37i97746
Kamalesh D Mali, Kalyani Krishna vairagade, Abhay Himmat Sabale, Pankaj Raju Vibhute, Janhavi Sunil Gorane, Nikita Suresh Kumawat, Manish Bansilal Gagarani & Vivek Sudam Kumawat·Journal of Pharmaceutical Research International·2025
Lornoxicam, a potent nonsteroidal anti-inflammatory drug (NSAID), suffers from poor aqueous solubility, leading to limited dissolution and variable bioavailability. It is a nonsteroidal anti-inflammatory medication (NSAID) that is commonly recommended to treat rheumatoid arthriti...
Open access
Research Article10.9734/jpri/2025/v37i97747
Dementia is a progressive neurodegenerative disease that significantly affects patients, caregivers, and health systems worldwide. Collaborative care models (CCMs) have emerged as promising strategies that integrate multidisciplinary interventions to improve patient outcomes and...
Open access
Research Article10.9734/jpri/2025/v37i97744
This study focuses on the synthesis, molecular docking, and anticancer activity evaluation of a series of novel pyridine derivatives (Compounds 7a-7g). The compounds were synthesized through a series of chemical reactions and characterized using spectroscopic methods. In vitro an...
Open access
Research Article10.9734/jpri/2025/v37i97745