Background: The most crucial mechanism of genetic variation in N. meningitidis is the slipped strand mispairing, this mechanism generates Phase variation using simple sequence repeat (SSR) and is commonly used by the N. meningitidis to escape the immune system despite its functio...
Open access
Research Article10.9734/ajbgmb/2022/v10i330248
Introduction: Type 2 Diabetes Mellitus (T2DM) is one of the most common metabolic diseases and poses a substantial burden on health care systems globally. There is compelling data that genetic susceptibility to T2DM is polygenic. Genome-wide association studies have identified al...
Open access
Research Article10.9734/ajbgmb/2022/v10i330246
Background: The current estimates by World Health Organization revealed that near 2030, the number of diabetic patients will reach up to 370 million in the world wide . It would be one of the most common degenerative illnesses in human beings in future that needs to seek urgent s...
Open access
Research Article10.9734/ajbgmb/2022/v10i330247
Background: According to GLOBOCAN estimates, breast cancer was found to be the most often diagnosed cancer in women worldwide, (11.7 %) and the fourth leading cause of cancer mortality (6.9 %). Aim: The purpose of this study is to investigate the role of the Angiotensin I-convert...
Open access
Research Article10.9734/ajbgmb/2022/v10i330245
Background: Gene therapy involves delivering therapeutic genomic material to a target tissue to modify expression of a protein or induce other characteristic changes. Recent advancements in the field, including FDA-approval of numerous gene therapies, are paving the way for futur...
Open access
Research Article10.9734/ajbgmb/2022/v10i330244
Aggregation of sickle haemoglobin (HbS), upon deoxygenation, is responsible for an inherited genetic disorder in the human red blood cells (RBCs) known as Sickle cell disease (SCD). On the suggestion that this phenomenon could arise from some form of conformational changes in the...
Open access
Research Article10.9734/ajbgmb/2022/v10i230243
Aim: This study was aimed at evaluating the effect of coadministration of lambda cyhalothrin and different local spices on testicular histology in Swiss mice Experimental Design: A completely randomized experimental design using standard methods for analysis. Location and Duratio...
Open access
Research Article10.9734/ajbgmb/2022/v10i230242
Purpose: Zinc status during gestation affects both maternal and fetal health. The study was designed to investigate maternal zinc status and relate it with dietary zinc and socioeconomic levels in first, second and third trimester pregnant women. Methods/Patients: Forty-five [15...
Open access
Research Article10.9734/ajbgmb/2022/v10i230241
Dopamine (dihydroxyphenethylamine) is an organic compound from the family of Catecholamines and Phenylamines and plays an important role in the brain functioning. Dopamine is synthesized by precursors in the kidneys and brain. Dopamine is among the essential neurotransmitters in...
Open access
Research Article10.9734/ajbgmb/2022/v10i230240
Disease conditions leading to pain are major healthcare problem worldwide. Incidences of pain related disorders have been on the increase worldwide. Although, several synthetic agents are available in treatment of these disorders, long-term usage has been reported to potentially...
Open access
Research Article10.9734/ajbgmb/2022/v10i230239
Genetic variations could be involved in the pathogenesis of diabetes. Type 2 diabetes (T2DM) accounts for 90% of all diabetes cases worldwide, however, the percentage is higher in the South Asian region. In this study, we observed the single nucleotide polymorphism (SNP) in GTF2H...
Open access
Research Article10.9734/ajbgmb/2022/v10i130237
Aim: This study was aimed at evaluating the hormonal profile of Swiss male mice administered lambda cyhalothin and extracts of some local spices. Experimental Design: A completely randomized experimental design using standard methods for analysis. Location and Duration of Study:...
Open access
Research Article10.9734/ajbgmb/2022/v10i130236
Aim: To synthesize silver nanoparticles (AgNPs) from Azadirachta indica leaf extract and determine its effect on membrane stability. Place and Duration of Study: Department of Biochemistry, Sokoto State University, Sokoto, Nigeria, between January 2021 and April 2021. Methodology...
Open access
Research Article10.9734/ajbgmb/2022/v10i130233
In the field of aquaculture, genetic engineering technology has been widely used in fish for production with the aims of increasing the growth rate of fish, regulating gonadal maturity, sex differentiation and sterility. One of the modern techniques that is expected to be a usefu...
Open access
Research Article10.9734/ajbgmb/2022/v10i130235
The effect of co-administration of ethanol leaves extracts of Andrographis paniculata and Phyllanthus amarus on albumin, globulin and bilirubin in a heavy metal treated albino Wistar rats was evaluated. Twenty-five male rats (130-170g) were assigned five groups of five animals ea...
Open access
Research Article10.9734/ajbgmb/2022/v10i130234