Heterocyclic compounds have a large spectrum of biological activities including antitumor activity. The present study describes the cytotoxic effect of newly synthesized thiazole derivative (TD2) that can prove effective antitumor activity on both in vivo and in vitro studies. Ob...
Open access
Research Article10.9734/ajrb/2018/v3i329831
Background: Thiazole nucleus–containing compounds have an antitumor efficiency against various types of cancer. Purpose: The present study was designed to determine the cytotoxic effect of newly synthesized thiazole derivative (TD1) on human cancer cell lines, in addition to eval...
Open access
Research Article10.9734/ajrb/2018/v3i229826
Aims: The present study aimed to elucidate the protective role of L-Arginine on lead – induced suppression of the pathway of heme synthesis and the toxicity of lead on testis. Methodology: The current study included two experiments; the first was carried out on two groups to foll...
Open access
Research Article10.9734/ajrb/2018/v3i229824
Aim: This study investigated the phytochemical constituents and in vitro antioxidant properties of methanol and aqueous leaf extracts of Geophila obvallata using standard methods. Materials and Methods: The in vitro antioxidant assays carried out were 1, 1‐diphenyl‐2‐picrylhydraz...
Open access
Research Article10.9734/ajrb/2018/v3i229823
One step centrifugation procedure used commonly for separation of blood cells is the ficoll gradient centrifugation. In this method, after centrifugation, the peripheral blood mononuclear cells (PBMCs) are located on the top of the separation fluid, whereas other blood cells eryt...
Open access
Research Article10.9734/ajrb/2018/v3i229820
Aim: This study evaluated the nephroprotective effect of methanol extract of Hymenocardia acida leaves in rat model of gentamicin induced renal damage. Materials and Methods: Twenty- four (24) Wistar albino rats of either sex weighing 150- 200g were divided into 4 groups of 6 ani...
Open access
Research Article10.9734/ajrb/2018/v3i229818
Background: The use of herbal medicines for treating ailments is rampant in recent years, and the toxicity implications of various plant preparations are sparingly reported. We investigated the potential effect of daily administration of aqueous extract of stem-bark of cashew tre...
Open access
Research Article10.9734/ajrb/2018/v3i129815
Aim: To determine the prevalence of toxoplasmosis and tuberculosis co-infection among (TB) patients. Study Design: A cross-sectional study was employed to gather data on 147 sputum positive TB patients. Place and Duration of Study: Bamenda Regional Hospital (BRH), Tuberculosis...
Open access
Research Article10.9734/ajrb/2018/v3i129812
Microorganisms establish a symbiotic relationship at all stages of growth in man, beginning from birth to adulthood. They are found in every part of the body, and they participate in the immune system against pathogen-mediated immune responses. Their actions are elicited by secre...
Open access
Research Article10.9734/ajrb/2018/v3i129810
Jatropha tanjorensis is a herbaceous plant used locally for the treatment of diabetes, inflammation, and stomach ache in Nigeria. Longtime effect of Jatropha tanjorensis on electrolyte concentrations in the body is yet to be determined. This study was conducted to determine elect...
Open access
Research Article10.9734/ajrb/2018/v3i129807
Background: The increasing emergence of resistance to conventional antimicrobial drugs and the complicity of their usage is a serious challenge in Nigeria. In our previous report, it was demonstrated that methanol leaves extracts of Acacia nilotica, Ziziphus jujube Linn and Lawso...
Open access
Research Article10.9734/ajrb/2018/v3i11057
Aim: Taq DNA polymerase from Thermus aquaticus is a key enzyme in the field of molecular biology that has been mostly used in polymerase chain reaction (PCR). Our aim is to produce standard grade Taq DNA polymerase free from censorious impurities like DNase, DNA and other contami...
Open access
Research Article10.9734/ajrb/2018/v2i4607
Aim: The role of nutrition in lipid metabolism continues to generate a lot of research interest, especially as dyslipidaemia is implicated in a host of diseases. The work investigated the effect of ethanol extract of Curcubita pepo leaves on the lipid profile of Wister rats. Met...
Open access
Research Article10.9734/ajrb/2018/v2i4601
Aim: This study is aimed at determining the levels of some heavy metals in the water, sediment and fishes (Oreochromis niloticus, Periopthalmus koelreuteri, Micropogonias undulatus, Carassius auratus and Liza felcipinis) from new Calabar River located at Rumuolumeni Community in...
Open access
Research Article10.9734/ajrb/2018/v2i4599
Background: Azadiradita indica seed has been used in traditional system of medicine. It is known to be natural medicine with many benefits. Toxicological studies have reported that toxic effects may be related to the complex mixtures of active constituents and other chemicals whi...
Open access
Research Article10.9734/ajrb/2018/v2i4561