Betulin, a lupane-type pentacyclic triterpene abundant in birch bark, is an accessible renewable scaffold for semisynthetic chemistry, while its 3,28-diacetate serves both as an isolable derivative and as a protected intermediate for further functionalization. This review critica...
Anastasia Golovina, Fedor Antipin, Vitaly Osyanin, Dmitry Osipov, Daniil Yakovlev, Olga Terina & Roman Ivanov·Organics·2026
The increasing prevalence of antimicrobial resistance has stimulated interest in non-antibiotic small molecules that can restore or potentiate the activity of established antibacterial agents. In this study, a focused series of low-molecular-weight chromene derivatives was synthe...
East Asian crowberry has been reported under Empetrum nigrum var. japonicum and E. nigrum subsp. asiaticum. This critical narrative review evaluates taxonomy, phytochemistry, and pharmacological evidence from Korean, Japanese, and Chinese source-reported material in the context o...
Priyanka R. Sakhare, Amit Kumar Jha, Praveen Kumar, Vittal Seema & Subba Rao Cheekatla·Organics·2026
The development of sustainable and efficient methods for carbon–carbon (C–C) bond formation remains the main objective in modern organic synthesis. In recent years, photocatalysis has developed as a suitable alternative to conventional transition-metal-catalyzed approaches, offer...
Oscar A. Douglas-Gallardo, Valentino Cárdenas-Toledo, Marta Navarro, Enrique Francés-Poveda, Jesús Naranjo, Genesys L. Mahecha, Felipe de la Cruz-Martínez, Francisca Werlinger, Agustín Lara-Sánchez & Javier Martínez·Organics·2026
The consistent increase in atmospheric CO2 concentration, mostly driven by the global combustion of fossil fuels, is considered one of the primary contributors to the increasing severity of environmental problems, like climate change and global warming. Attending to this issue re...
Fluorinated isoquinoline-1,3-diones possess important biological activities and application value in many fields such as medicine, pesticides, and organic synthesis. This review summarizes the synthetic methods of fluorinated isoquinoline-1,3-diones reported in recent years, main...
Active molecules derived from traditional Chinese medicine (TCM) represent a valuable source of lead compounds for modern drug discovery, demonstrating considerable potential in the prevention and treatment of chronic diseases, cancer therapy, and immune modulation. Nevertheless,...
Flexible organic solar cells (FOSCs) are a promising green energy technology due to their mechanical flexibility, light weight, low cost, and compatibility with large-area solution processing. Although the power conversion efficiency (PCE) of rigid organic solar cells has exceede...
Md. Shamim Alam, Mashud Ahmed, Abdul Barik, Samia Jahan Tofa, Md. Koushic Uddin, Antonio Greco, Mohammad Mahbubul Alam & Muksit Ahamed Chowdhury·Organics·2026
Due to the rapid development of the textile industry and increased consumption of various textiles composed of both synthetic and natural fibers, large amounts of textile waste are produced, leading to environmental and economic problems on a global scale. Turning textile waste i...
Pancreatic ductal adenocarcinoma (PDAC) is considered as one of the most lethal malignancies, characterized by late diagnosis, aggressive local invasion, profound therapy resistance, and a suppressive tumor microenvironment. Currently known chemotherapy regimens for the treatment...
Heidi A. Dahlmann, Finn Beruldsen, Hayden L. Criswell, Phillip F. Crook, Evan C. Glassford, Alyssa K. Jones, Reece B. Mitchell, Laura F. Mortan, Nicholas Ryan, Alexandria M. Smith & Evan M. Vazquez·Organics·2026
Ring-closing carbonyl-olefin metathesis (COM) reactions provide a straightforward method for producing cyclic alkenes from precursors containing carbonyl functional groups tethered to nucleophilic alkenes. Within the last decade, many methods for carrying out Lewis acid- or organ...
Phenylglycine (Phg) is a nonproteinogenic α-amino acid found in various bioactive molecules. The C-terminal activation of N-acyl Phg is often accompanied by oxazolone-mediated racemization, arising from the direct attachment of the phenyl ring to the α-carbon. After peptide bond...
We have prepared two novel tethered (arene)Ru(II)/TsDPEN complexes, one containing a p-OTBS on the η6-arene ring, and the other with a p-CO2Et group at the same position, representing an electron-rich and electron-poor derivative. These have been evaluated in asymmetric transfer...
Anastasia R. Kovrizhina & Andrei I. Khlebnikov·Organics·2026
Ninhydrins represent a promising chemical space for the search for new biologically active molecules with antimicrobial, antiprotease, and antitumor properties. In the present work, new ninhydrin derivatives were synthesized, and for the first time, a systematic in silico study o...
Shai Ben Sasson, Noa Naama, Mikhail Kozlov, Ibrahim Amer & Moshe Portnoy·Organics·2026
Our recent studies demonstrated that dialkylaminopyridine organocatalysts featuring an extensive secondary sphere preferentially phosphorylate the alcohol at the apolar domain of a model amphiphilic diol. In the present study, this site-selective behavior was corroborated across...