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An Overview of Pyrazole-Tetrazole-Based Hybrid Compounds: Synthesis Methods, Biological Activities and Energetic Properties

Mounir Cherfi, Tarik Harit, Malika Amanchar, Ahlam Oulous & Fouad Malek · Organics · 2024

Pyrazole and tetrazole are among the most important heterocyclic members of the azole family. Over the past decade, these N-heterocycles and their derivatives have demonstrated specific properties that give them potent applications in several fields such as pharmacology, technolo...

Open access Research Article 10.3390/org5040030

A New Generation of Porous Polymer Materials from Polystyrene Waste: Synthesis and Adsorption of Nitrate Anions in Aqueous Media

Mohamed Anannaz, Fatiha Tafraout, Charaf Laghlimi, Rachida Ouaabou & Jalal Isaad · Organics · 2024

A simple approach was developed to efficiently graft diethylene triamine onto polystyrene waste using succinic anhydride as a tracer to remove nitrate anions from aqueous solutions. Infrared spectroscopic data showed characteristic signs at 3395 cm−1 and 1695 cm−1 corresponding t...

Open access Research Article 10.3390/org5040029

Advances in Organic Materials for Next-Generation Optoelectronics: Potential and Challenges

Ghazi Aman Nowsherwan, Qasim Ali, Umar Farooq Ali, Muhammad Ahmad, Mohsin Khan & Syed Sajjad Hussain · Organics · 2024

This review provides a comprehensive overview of recent advancements in the synthesis, properties, and applications of organic materials in the optoelectronics sector. The study emphasizes the critical role of organic materials in the development of state-of-the-art optoelectroni...

Open access Research Article 10.3390/org5040028

1,5-Acrylodan: A Fluorescent Bioconjugate Sensor of Protic Environments

Jake Morrin, Matthew Petitt & Christopher Abelt · Organics · 2024

1,5-Acrylodan (1-(5-(dimethylamino)naphthalen-1-yl)prop-2-en-1-one) is prepared in six steps from 1-nitronaphthalene and 19% overall yield. The last three steps involve an aryllithium-directed nucleophilic addition, catalytic Kulinkovich cyclopropanation, and copper-catalyzed oxi...

Open access Research Article 10.3390/org5040026

Synthesis of Thieno[3,2-b]thiophenes from 2,5-Dicarbonyl 3-Nitrothiophenes via Nucleophilic Aromatic Substitution of the Nitro Group with Thiolates

Roman A. Irgashev & Nikita A. Kazin · Organics · 2024

In this study, we developed an efficient strategy for constructing thieno[3,2-b]thiophene molecules from 3-nitrothiophenes, containing carbonyl fragments at the C-2 and C-5 atoms, by nucleophilic aromatic substitution of the nitro group in these substrates. It was shown that the...

Open access Research Article 10.3390/org5040027

Recent Developments Towards the Synthesis of Triazole Derivatives: A Review

Issam Ameziane El Hassani, Khouloud Rouzi, Anouar Ameziane El Hassani, Khalid Karrouchi & M’hammed Ansar · Organics · 2024

The triazole scaffold is a crucial component of heterocyclic chemistry, serving as a basic building block in organic synthesis, materials science, and medicinal chemistry. Triazole is a five-membered ring composed of three nitrogen atoms and two carbon atoms, and it exists in two...

Open access Research Article 10.3390/org5040024

Pd EnCat™ 30 Recycling in Suzuki Cross-Coupling Reactions

Laura D’Andrea & Casper Steinmann · Organics · 2024

Pd EnCat™ 30 is a palladium catalyst broadly used in several hydrogenation and cross-coupling reactions. It is known for its numerous beneficial features, which include high-yielding performance, easy recovery, and reusability. However, the available data regarding its recyclabil...

Open access Research Article 10.3390/org5040023

Aldehydes: What We Should Know About Them

Alessia Catalano, Annaluisa Mariconda, Assunta D’Amato, Domenico Iacopetta, Jessica Ceramella, Maria Marra, Carmela Saturnino, Maria Stefania Sinicropi & Pasquale Longo · Organics · 2024

From Egyptian mummies to the Chanel N° 5 perfume, aldehydes have been used for a long time and continue to impact our senses in a wide range of perfumes, foods, and beverages. Aldehydes represent one of the categories of volatile organic compounds (VOCs), which are categorized as...

Open access Research Article 10.3390/org5040021

Polycyclic Tetramate Macrolactams and Their Potential as Anticancer Agents

Alexandria Montavon, M. Raquel Marchán-Rivadeneira & Yong Han · Organics · 2024

Natural products have been a reliable source of drug compounds in medical research. Technological advances have led to the discovery and characterization of many compounds that were previously difficult to isolate. However, when searching for anticancer drugs, finding natural com...

Open access Research Article 10.3390/org5040019

Amphiphilic Fluorescein Triazoles: Synthesis and Visible-Light Catalysis in Water

Alina Artemenko, Elza Sultanova, Diana Mironova, Aliya Akhatova, Ekaterina Bondareva, Daut Islamov, Konstantin Usachev, Svetlana E. Solovieva, Vladimir Burilov & Igor Antipin · Organics · 2024

Triazole derivatives of fluorescein-containing N,N-dimethylaminopropyl fragments and their ammonium salts were synthesized with yields of 74–85%. The resulting compounds exhibit fluorescent properties in the green region of the visible spectrum. The critical aggregation concentra...

Open access Research Article 10.3390/org5030018

A Review on Barbituric Acid and Its Derivatives: Synthesis, Reactions, and Bio-Applications

Navneet Kaur, Manvinder Kaur, Harvinder Singh Sohal, Haesook Han & Pradip K. Bhowmik · Organics · 2024

Barbituric acid is a heterocyclic compound with various pharmacological and biological applications. This review paper provides a comprehensive overview of barbituric acid’s synthesis, reactions, and bio-applications, highlighting its multifaceted role in various fields. Many het...

Open access Research Article 10.3390/org5030017

New Generation of Hybrid Pyrazole–Tetrazole Tetrapodal Compounds: Synthesis and Biological Activities

Malika Amanchar, Tarik Harit, Mounir Cherfi, Meryem Idrissi Yahyaoui, Nour Elhouda Daoudi, Abderrahmane Yahyi, Abdeslam Asehraou & Fouad Malek · Organics · 2024

The elaboration of a new family of tetrapodal molecules L1–L3 bearing two pyrazole–tetrazole units is presented. The structure assigned to such molecules was verified by various techniques, including FTIR, NMR, HRMS and elemental analysis. The ability of these tetrapods to inhibi...

Open access Research Article 10.3390/org5030016

The Use of Heterocyclic Azo Dyes on Different Textile Materials: A Review

Lucia Emanuele & Maurizio D’Auria · Organics · 2024

The art of dyeing textiles has a long history, as natural dyes have been used since prehistoric times. With the development of synthetic dyes in the 19th century, the focus shifted from natural to synthetic dyes due to their superior properties. Recently, however, interest in nat...

Open access Research Article 10.3390/org5030015