Aleksandr Urakov, Petr Shabanov, Konstantin Gurevich, Evgeny Fisher, Anastasia Stolyarenko, Daria Suntsova, Ilnur Yagudin & Nikita Muhutdinov·Journal of Pharmaceutical Research International·2023
It is reported that the interaction of hydrogen peroxide and sodium bicarbonate solution with thick sputum, mucus, pus and blood clots leads to their rapid transformation into a fluffy oxygenated foam. This mechanism of action allows repurposing hydrogen peroxide from antiseptic...
Open access
Research Article10.9734/jpri/2023/v35i97348
Aleksandr Urakov, Natalya Urakova, Alexey Reshetnikov, Albina Shchemeleva, Petr Shabanov, Lubov Lovtsova, Aleksandr Samorodov, Evgeny Fisher, Anastasia Stolyarenko, Daria Suntsova, Ilnur Yagudin & Nikita Muhutdinov·Journal of Pharmaceutical Research International·2023
Pyolytics are drugs that dissolve thick pus when applied topically. This group of drugs was discovered in early 21st century in Russia as a result of successful repurposing of antiseptics hydrogen peroxide, sodium bicarbonate and sodium chloride from antiseptics to pyolytics. Pri...
Open access
Research Article10.9734/jpri/2023/v35i67333
Until today, the mechanism of action of drugs is traditionally considered without taking into account the physical-chemical properties of dosage forms. However, at the beginning of the 21st century, there were reports that all drugs contain unaccounted gases that enter drugs from...
Open access
Research Article10.9734/jpri/2023/v35i37315
Aleksandr Urakov, Natalya Urakova, Evgeny Fisher, Ilnur Bashirov, Sabina Nurlanova, Anastasia Klimovich, Albina Fakhretdinova, Anvar Bakirov, Regina Balametova & Aleksandr Samorodov·Journal of Pharmaceutical Research International·2022
It has been shown that some drugs considered to be of good quality today can cause an iatrogenic disease known as Nicolau syndrome. Nicolau syndrome is a rare cutaneous drug reaction occurring after injection many drugs. This disease has been found to be caused by the very strong...
Open access
Research Article10.9734/jpri/2022/v34i33A36123
It has been established that some nonsteroidal anti-inflammatory drugs (NSAIDs) when administered through injectable preparations have a local irritating effect, even though the preparations are considered high-quality. It seems that this local irritant action is not related to a...
Open access
Research Article10.9734/jpri/2022/v34i19A35803
It is established that very few modern high-quality drugs in the dosage form "Solution for injection" have isoosmotic activity in the range of 280-300 mosmol/l of water. The main part of solutions for injection is hypotonic or hypertonic solutions, which can have osmotic activity...
Open access
Research Article10.9734/jpri/2021/v33i59B34428
It has been established that warm alkaline solutions of hydrogen peroxide with local interaction with thick pus, mucus, sputum and blood have local pyolytic, mucolytic and hemolytic effects. It was found that the dissolving effect is associated with the alkaline properties of the...
Open access
Research Article10.9734/jpri/2022/v34i30B36073