Intrapulmonary Use of Hydrogen Peroxide in Respiratory Obstruction: Initial Results Demonstrate the Possibility of Airway Recanalization and Blood Reoxygenation through  the Lungs: An Update

Aleksandr Urakov; Petr Shabanov; Konstantin Gurevich; Evgeny Fisher; Anastasia Stolyarenko; Daria Suntsova; Ilnur Yagudin; Nikita Muhutdinov

doi:10.9734/jpri/2023/v35i97348

Research Article Open access CC BY 4.0

Intrapulmonary Use of Hydrogen Peroxide in Respiratory Obstruction: Initial Results Demonstrate the Possibility of Airway Recanalization and Blood Reoxygenation through the Lungs: An Update

Aleksandr Urakov, Petr Shabanov, Konstantin Gurevich, Evgeny Fisher, Anastasia Stolyarenko, Daria Suntsova, Ilnur Yagudin, Nikita Muhutdinov

Journal of Pharmaceutical Research International · pp. 33–37 · Published 24 Apr 2023

10.9734/jpri/2023/v35i97348

Abstract

It is reported that the interaction of hydrogen peroxide and sodium bicarbonate solution with thick sputum, mucus, pus and blood clots leads to their rapid transformation into a fluffy oxygenated foam. This mechanism of action allows repurposing hydrogen peroxide from antiseptic to expectorant and oxygen forming antihypoxant, which can find application for recanalization of airways and increasing blood oxygenation in acute respiratory syndrome. It is reported that acute respiratory distress syndrome in COVID-19 can be caused by excessive accumulation of thick sputum, mucus and pus in the airways, which complicates intra-pulmonary oxygenation of blood, causes hypoxia and causes death, since there are no drugs for urgent recanalization of the airways today. At the same time, the first evidence emerged that alkaline hydrogen peroxide solution can claim to be an inhaled expectorant and oxygen-producing drug for urgent recanalization of the airways when they are blocked by mucus, sputum, pus, blood and other colloidal fluid containing the enzyme catalase.

lung samples respiratory obstruction hypoxia catalase hydrogen peroxide

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Aleksandr Urakov, Petr Shabanov, Konstantin Gurevich, Evgeny Fisher, Anastasia Stolyarenko, Daria Suntsova, Ilnur Yagudin, Nikita Muhutdinov (2023). Intrapulmonary Use of Hydrogen Peroxide in Respiratory Obstruction: Initial Results Demonstrate the Possibility of Airway Recanalization and Blood Reoxygenation through the Lungs: An Update. Journal of Pharmaceutical Research International , 33–37. https://doi.org/10.9734/jpri/2023/v35i97348

Affiliations

Aleksandr Urakov — Department of General and Clinical Pharmacology, Izhevsk State Medical Academy, Kommunarov Str., 281, 426034, Izhevsk, Russia.
Petr Shabanov — Department of Neuropharmacology, Institute of Experimental Medicine, Acad, Pavlov Str., 12, 197022, Saint Petersburg, Russia.
Konstantin Gurevich — UNESCO Chair “Healthy Lifestyle is a Key to Successful Development”, Moscow State University of Medicine and Dentistry, Moscow, Russia.
Evgeny Fisher — Department of General and Clinical Pharmacology, Izhevsk State Medical Academy, Kommunarov Str., 281, 426034, Izhevsk, Russia.
Anastasia Stolyarenko — Department of General and Clinical Pharmacology, Izhevsk State Medical Academy, Kommunarov Str., 281, 426034, Izhevsk, Russia.
Daria Suntsova — Department of General and Clinical Pharmacology, Izhevsk State Medical Academy, Kommunarov Str., 281, 426034, Izhevsk, Russia.
Ilnur Yagudin — Department of General and Clinical Pharmacology, Izhevsk State Medical Academy, Kommunarov Str., 281, 426034, Izhevsk, Russia.
Nikita Muhutdinov — Department of General and Clinical Pharmacology, Izhevsk State Medical Academy, Kommunarov Str., 281, 426034, Izhevsk, Russia.

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