Olufunso O. Olorunsogo

Induction of Mitochondrial-Mediated Apoptosis by Solvent Fractions of Methanol Extract of Heliotropium indicum in Rat Liver Cells

Adeola O. Olowofolahan, Yemisi D. Adeoye & Olufunso O. Olorunsogo · Annual Research & Review in Biology · 2017

Aim: Mitochondrial Membrane Permeability Transition (MMPT) pore has emerged as a promising target for drug development because the release of cytochrome c upon the opening of the pore is a point of no return for mitochondrial-mediated apoptosis to occur. Heliotropium indicum (HI)...

Open access Research Article 10.9734/ARRB/2017/36334

Evaluation of the Effects of Fractions of Jatropha curcas (Linn) Leaves on Mitochondrial Permeability Transition in Rat Liver

Olubukola T. Oyebode, Wuraola R. Owaboye, Opeyemi F. Akinbisoye & Olufunso O. Olorunsogo · Annual Research & Review in Biology · 2017

Aim: Modulation of the opening of mitochondrial Permeability Transition (mPT) pore is an important   pharmacological target in drug design because the release of cytochrome C upon the opening of the pore is sine qua non for mitochondrial-mediated apoptosis to take place. Jatropha...

Open access Research Article 10.9734/ARRB/2017/35882

Investigating the Modulatory Effect of Methanol Extract of Daniellia oliveri (ROLFE) Leaves on Mitochondrial Membrane Permeability Transition (MPT) Pore

Jonah Achem, Cosmos Ifeanyi Onyiba, Mobolaji T. Akinwole, Jemimah M. Malgwi, Omosola L. Bolarin & Olufunso O. Olorunsogo · International Journal of Biochemistry Research & Review · 2020

Background: Mitochondrial-mediated cell death begins with opening of mitochondrial membrane permeability transition (mPT) pore and medicinal plants contain phytochemicals that modulate the mPT pore. Hypothesis and Purpose: We investigated the modulatory effects of crude methanol...

Open access Research Article 10.9734/ijbcrr/2020/v29i930223