Leukoplakia is a potentially malignant disorder affecting the oral cavity. Early detection and prompt treatment are the keys to prevent its malignant transformation. Various treatment modalities have been discussed in multiple literatures, broadly categorized into non-surgical an...
Open access
Research Article10.9734/jcti/2025/v15i3304
Background: Synchronous primary malignancies, characterised by the diagnosis of two or more histologically distinct cancers within six months, are uncommon, and data from Sub-Saharan Africa is limited. Their occurrence in young individuals, particularly with colorectal and ovaria...
Open access
Research Article10.9734/jcti/2025/v15i3303
Chemobrain, or chemotherapy-induced cognitive impairment (CICI), is a significant side effect affecting cancer survivors, characterized by neuroinflammation and oxidative stress. This review examines the potential role of astaxanthin, a potent antioxidant and anti-inflammatory ca...
Open access
Research Article10.9734/jcti/2025/v15i3302
Perfusion imaging is an advanced technique for evaluating the blood flow of the microvasculature of any tissue or pathology. It refers to the passing of blood from the arterial system to the vascular system through the microvasculature of tissues. It may be affected in abnormal t...
Open access
Research Article10.9734/jcti/2025/v15i3301
Background: Binucleated cells are a type of cell that contains two nuclei within their cytoplasm and are commonly observed in both normal and pathological conditions. They play essential roles in physiological processes, such as tissue repair and adaptation, and are also implicat...
Open access
Research Article10.9734/jcti/2025/v15i3300
Josiah Stephen, Ikechukwu Kanu, Nwamaka Nneka Onyedum, Edibokun Theresa Orobator, Catherine Rono, Ngwoke, Chinaza Faith, Victor Omeiza David, Wonderful Oluwatoyin Anosike & Lawrence John AJutor·Journal of Cancer and Tumor International·2025
HLA class I molecules are essential for presenting tumour antigens to cytotoxic T-cells, but their dysregulation in cancer enables immune evasion and limiting the efficacy of immunotherapies for cancer. The objective of this review is to explore the function of HLA class I change...
Open access
Research Article10.9734/jcti/2025/v15i3299
Background: There is an upsurge of cervical cancer cases worldwide, of which Ghana is no exception. However, despite the growing population of women suffering from this disease, not much research has been done. According to studies undertaken in other countries, survivors of cerv...
Open access
Research Article10.9734/jcti/2025/v15i3298
Oseghale, Ikalo David, Ikokwu, Godwin Mmaduabuchi, Ugoagwu, Kingsley Ugonna, Elizabeth Anuoluwa Akintayo, Matthew Gyang, Okiki Nosiru Quadri, Catherine Rono, Osedebamen Hilary Ralph-Okhiria & Odunvbun Praise·Journal of Cancer and Tumor International·2025
The tumor microenvironment (TME) is the complex ecosystem surrounding a tumor. It is a complex and continuously evolving entity. The TME comprises a variety of complex components, such as cancer cells, immune cells, stromal cells, and extracellular matrix, that precisely regulate...
Open access
Research Article10.9734/jcti/2025/v15i2297
The objective of this article is to promote abnormal methylation enzymes (MEs) as a critical cause of cancer and the destabilization of abnormal MEs as a new approach to direct cancer therapy. MEs are a ternary enzyme complex consisting methionine adenosyltransferase (MAT)-methyl...
Open access
Research Article10.9734/jcti/2025/v15i2295
Lawrence John AJutor, Edibokun Theresa Orobator, Blessing Ben- Anioke, Victor Chiedozie Ezeamii, Mayowa Josiah Badmus, Uchechi Ngozichukwu Obiefule, Vincent Barrah, Mary Oluwabunmi Oyebode & Josiah Stephen·Journal of Cancer and Tumor International·2025
BRCA1 and BRCA2 genes, located on separate chromosomes, encode crucial multifunctional proteins that are important for correcting errors in DNA replication and cell division. The two genes work in tandem at different stages in the DNA damage response and for DNA repair and could...
Open access
Research Article10.9734/jcti/2025/v15i2296