Background: Emblica officinalis (amla) is known for its vitamin C-rich fruit, but its root remains underexplored. Ascorbic acid (vitamin C) is a vital plant antioxidant that plays essential roles in stress responses. We investigated E. officinalis root as a potential source of vi...
Open access
Research Article10.9734/jpri/2025/v37i127780
Scope and Objective: Metered-dose inhalers (MDIs) remain the cornerstone of inhalation therapy for asthma and chronic obstructive pulmonary disease (COPD), offering a portable, efficient, and cost-effective means of delivering drugs directly to the lungs. The global MDI market is...
Open access
Research Article10.9734/jpri/2025/v37i127778
Background: Manufactured chemicals are the second important classes as the natural chemicals mentioned above and the American Chemistry Council (ACC) projects global chemical production to rise by 3.4 % in 2024 and 3.5 % in 2025, after increasing just 0.3 % in 2023. Exist a varie...
Open access
Research Article10.9734/jpri/2025/v37i127777
Issouf Fofana, Aboubakar Traoré, Bafétigué Ouattara, Akassa Marius Bernard Djako, N'goran Urbain Florent Niangoran, Souleymane Konate & Eugene Megnassan·Journal of Pharmaceutical Research International·2025
Alzheimer's disease (AD) accounts for 60 to 70% of dementias worldwide. This condition is primarily associated with the decrease in acetylcholine (ACh) levels, due to the action of human acetylcholinesterase (AChE). The lack of a curative treatment for Alzheimer's disease undersc...
Open access
Research Article10.9734/jpri/2025/v37i127776
Bedoor Turky, Basmah Alotaibi, Aryam H. Alzahrani, Maryam H. Khan, Ghala M. Althubaiti, Khalid Adel, Shahad AlFaisal, Aljazy Alhasson, Nouf Alhathloul, Lama A. Albishri, Danah A. Alsharif, Hind Alrshidi, Fatimah Mslam, Lara M. Samhan & Baraa Alghalayini·Journal of Pharmaceutical Research International·2025
Alopecia areata (AA) is an autoimmune disorder characterised by patchy hair loss and a significant psychological impact. Although traditionally attributed to Th1-mediated pathways, emerging evidence highlights roles for Th2, Th9, and IL-23 signalling. This study aims to perform a...
Open access
Research Article10.9734/jpri/2025/v37i127775
Aubin N’GUESSAN, Ludovic Akonan, Désiré MELEDJE, Hermann N’Guessan, Gabin Placide ALLANGBA, Logbo MOUSSE, Nahossé Ziao, Melalie Keita, Raymond KRE & Eugene Megnassan·Journal of Pharmaceutical Research International·2025
This study developed a random forest (RF) model based on a large and diverse dataset to classify whether organic chemicals or drugs are respiratory toxicants. Indeed, the concerns regarding drug-induced respiratory remain a major cause of drug candidate failure in clinical trials...
Open access
Research Article10.9734/jpri/2025/v37i127774
Nicholas Muparadzi, Waraidzo Juliet Nyatsine, Ropafadzo Madondo, Daisy Kudzai Kahwenga, Tinashe Goronga, Alfredy Tapiwa Chidyiwa & Kurai Gareth Mawoneke·Journal of Pharmaceutical Research International·2025
Drug and substance abuse is a growing public health threat in Zimbabwe, with potential to affect the economic growth of the nation. Globally, there is an increase in the number of people who use drugs. In 2013, UNODC estimated that 246 million people had used a drug in the previo...
Open access
Research Article10.9734/jpri/2025/v37i117773
Aims: Different types of drug release modifying polymers, their grades and quantities have to be optimised in the formulation considering solubility characteristics and biological half-life of the drugs. Further, formulations containing such discrete ingredients processed by conv...
Open access
Research Article10.9734/jpri/2025/v37i117772
Future medical equipment is being gradually shaped by artificial intelligence, which offers accuracy, personalization, and efficiency in healthcare. By improving patient outcomes and enhancing surgical and diagnostic precision, artificial intelligence (AI) is transforming orthope...
Open access
Research Article10.9734/jpri/2025/v37i117771
Background: Raspberry Ketone (RK, 4-(4-hydroxyphenyl)butan-2-one) is a naturally occurring phenolic compound in various fruits (e.g., raspberry, peach). Recent years have seen multidisciplinary research interests into its chemical properties, mechanistic pharmacology, safety prof...
Open access
Research Article10.9734/jpri/2025/v37i117770