Introduction: Angular cheilitis is defined as the localised inflammation of the lip commissure. The angles of the mouth are more prone to inflammation as they serve as the points of interface between the squamous epithelium and oral mucosa. It is a multifactorial disease and occu...
Open access
Research Article10.9734/jpri/2021/v33i64B35807
CDK5 (cyclin dependent kinase 5) is a promising target for treating a variety of neurodegenerative illnesses. The discovery of effective and selective CDK5 inhibitors that engage the polar side chains of the ATP-binding pocket as well as establish specific hydrogen bonds with the...
Open access
Research Article10.9734/jpri/2021/v33i64B35946
To increase the effectiveness of tacrolimus, the present study sought to develop extended-release tablets. It is used to treat mild to severe atopic dermatitis as well as to prevent organ rejection after organ transplantation. Tacrolimus, on the other hand, has a poor bioavailabi...
Open access
Research Article10.9734/jpri/2021/v33i64B35978
The joint hypermobility syndrome is a condition that characterises joints that are mobile past the range expected for that particular joint. Hypermobility has a significant impact on quality of life of affected individuals. Hypermobile individuals may be more susceptible to muscu...
Open access
Research Article10.9734/jpri/2021/v33i64B35979
Background: Every human race has its own traditional system of medicines. Siddha system of medicine is unique and ancient of its kind originating from Tamil Nadu in India. Siddha system could be considered as the crown of all the traditional arts of the ancient Tamil. Eraippu Noi...
Open access
Research Article10.9734/jpri/2021/v33i64B35981
The genus Miliusa (Annonaceae) has over 60 species that are native to India, Bhutan, Australia, and New Guinea, but are mostly found in numerous Asian nations such as Vietnam, Thailand, and China. The growing interest in secondary metabolites' potent biological action highlighted...
Open access
Research Article10.9734/jpri/2021/v33i64B35996
Obeticholic acid is a farnoside X receptor agonist that was recently licenced by the US Food and Drug Administration. In a solvent, solubility is lower, therefore it is necessary to improve solubility. Solid dispersion is one of the most effective methods for increasing Obetichol...
Open access
Research Article10.9734/jpri/2021/v33i64B36003
Objective: The study aimed to compare the reliability of different cephalometric angles like the Beta, Yen, W and Pi angles to evaluate sagittal dysplasia in various skeletal patterns and assess the correlation between the variables. Materials and Methods: 135 pre-treatment later...
Open access
Research Article10.9734/jpri/2021/v33i64B36004
Introduction: Xerostomia is a dry mouth condition caused by insufficient or absent saliva flow. Xerostomia is not a disorder, but it may be a symptom of a variety of diseases, a side effect of head and neck radiation, or a side effect of a number of drug medications. It may be li...
Open access
Research Article10.9734/jpri/2021/v33i64B36012
Indoline 2, 3-dione and substituted Indoline 2, 3-dione derivatives were reacted with N-(4-(4-aminophenylsulphonyl) phenyl) acetamide to generate a variety of Schiff's bases. Using these compounds' Mannich bases were created by reacting them with formaldehyde and secondary amine...
Open access
Research Article10.9734/jpri/2021/v33i64B36014