A Mini Review of Gastrointestinal Pathology and Nutrition in Autism Spectrum Disorder
Pradeep V. Mahajan, Prachi S. Salvi, Siddhant Mahajan, Swetha Subramanian
Journal of Advances in Medicine and Medical Research · pp. 1–8 · Published 15 Jun 2019
10.9734/jammr/2019/v29i1130144Abstract
Autism spectrum disorder (ASD) is a complex, heterogenous group of neurodevelopmental disorders that result due to interaction of genes and environmental factors. ASD is associated with behavioural alterations and deficits in social communication. Current research on pathophysiology has proposed a link between severity of symptoms of ASD and gastrointestinal disturbances. Intestinal inflammation, dysregulation of gut microbiome may affect intestinal permeability, mucosal immune function and subsequently cause GI symptoms. Studies have also proposed the role of metabolic activity of the gut microbiome and dietary components (food allergens/toxins) to be associated with behavioral alterations in neurodevelopmental conditions including ASD. The present review aims to highlight the potential role of nutrients and dietary changes on gastrointestinal pathology and symptoms of ASD.
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