A Novel Synthesis of 1,2,3triazole Substituted Pyrimidine, Pyrazole by Using 1,2,3triazolchalcone
A. J. Shadakshari, T. H. Suresha Kumara, H. B. V., A. J. Yamuna
Journal of Pharmaceutical Research International · pp. 55–66 · Published 26 Jan 2022
10.9734/jpri/2022/v34i5A36312Abstract
A series of 1- benzyl-5-methyl 1,2,3 triazole pyrimidine , 1- benzyl-5-methyl 1,2,3 triazole pyrazole were synthesised by using intermediate as phenyl Substituted prop-2-en-1-one .We obtained pyrazole when we treated propenones by using hydrazine hydrate and we obtained pyrimidine by using urea and thiourea. Conformations of the compounds were done by 1HNMR and C13 NMR analysis and these compounds were screened for antimicrobial activities. Graphical Abstract
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