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Research Article Open access CC BY 4.0

A Rare Incidence of Ethambutol Induced Toxic Optic Neuropathy

M. V. Mousigan, L. Nissi, V. Sreenivasan

International Journal of Medical and Pharmaceutical Case Reports · pp. 1–5 · Published 2 Jan 2023

10.9734/ijmpcr/2023/v16i1322

Abstract

Ethambutol induces toxic optic neuropathy (EON), which most typically presents as bilateral symmetrical loss of vision and, due to a lack of early detection and adequate treatment, often causes serious irreversible visual impairment. EON is time and dose dependent. In this case report, we will discuss a 59-year-old female patient who came in with complaints of visual impairment, inclusive of a colour vision defect (dyschromatopsia) and blurred vision (scotoma). Her past medication history includes use of first-line anti-tubercular therapy (ATT) with four drugs: Rifampicin, Isoniazid, Ethambutol, and Pyrazinamide. Pyrazinamide was taken for two months, and other medications (Rifampicin, Isoniazid, and Ethambutol) were taken for a period of seven months. From this case report, we will get a clear picture necessitating continuous monitoring for ocular toxicity.

Ethambutol-induced Optic Neuropathy (EON) Anti-Tubercular Therapy (ATT) reversible Duration and dose dependent

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