A Study of Bcl-2 Immuno-expression in Invasive Ductal Carcinoma of Breast and it’s Correlation with Molecular Sub-types

Abstract

Background: The incidence of Breast cancers has overtaken the cervical cancers amongst Indian females. Invasive Ductal carcinoma is reported to be the most common form of breast cancer. Bcl-2 has been studied extensively as a common factor in the pathogenesis of solid tumours including  breast cancer. Bcl-2 is an anti-apoptotic protein normally expressed in mammary tissue and is up-regulated by oestrogen in breast cancer through direct consequence of transcriptional induction. The present study attempts to look into Bcl-2 immunoexpression as  a key parameter for predicting the treatment outcomes and recurrence of Invasive Ductal Carcinoma.  Methodology : This will be an observational study conducted in Department of Pathology, JNMC, Wardha. The study will include clinicopathological detailing of  50 mastectomy specimens of Invasive ductal carcinoma, detailed sectioning of tumour tissues, histopathological BR-grading and molecular subtyping using Bcl-2 immunohistochemistry. Expected Results: A significant correlation is expected between Bcl-2 expression and treatment outcomes and recurrence of Invasive Ductal Carcinoma.  Conclusion: The conclusion will be drawn based on careful analysis of the results.